GB2068002B - Plasminogen preparation and their production - Google Patents

Plasminogen preparation and their production

Info

Publication number
GB2068002B
GB2068002B GB8100338A GB8100338A GB2068002B GB 2068002 B GB2068002 B GB 2068002B GB 8100338 A GB8100338 A GB 8100338A GB 8100338 A GB8100338 A GB 8100338A GB 2068002 B GB2068002 B GB 2068002B
Authority
GB
United Kingdom
Prior art keywords
plasminogen
preparation
aqueous solution
production
resulting solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8100338A
Other versions
GB2068002A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GREEN CROSS CORP
Mitsubishi Tanabe Pharma Corp
Original Assignee
GREEN CROSS CORP
Green Cross Corp Japan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP807280A external-priority patent/JPS56106594A/en
Priority claimed from JP9134180A external-priority patent/JPS5716824A/en
Application filed by GREEN CROSS CORP, Green Cross Corp Japan filed Critical GREEN CROSS CORP
Publication of GB2068002A publication Critical patent/GB2068002A/en
Application granted granted Critical
Publication of GB2068002B publication Critical patent/GB2068002B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin

Abstract

A plasminogen preparation contains at least one of a physiologically acceptable inorganic salt, lysine, a salt thereof, phenylmethanesulfonyl fluoride, aprotinin, or soybean trypsin inhibitor in an amount effective for stabilizing plasminogen. The preparation may take the form of an aqueous solution or a dry powder. The preparation can be prepared by adding the abovementioned stabilizer or stabilizers to an aqueous solution containing plasminogen, if necessary subjecting the resulting solution to digestion at 4 DEG to 37 DEG C at pH 2 to 4 for 20 to 60 minutes, and then to heat-treatment at 60 DEG C for 10 hours, and lyophilizing the resulting solution.
GB8100338A 1980-01-25 1981-01-07 Plasminogen preparation and their production Expired GB2068002B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP807280A JPS56106594A (en) 1980-01-25 1980-01-25 Stabilizing method of plasminogen
JP9134180A JPS5716824A (en) 1980-07-03 1980-07-03 Plasminogen pharmaceutical and stabilizing method thereof

Publications (2)

Publication Number Publication Date
GB2068002A GB2068002A (en) 1981-08-05
GB2068002B true GB2068002B (en) 1983-06-29

Family

ID=26342511

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8100338A Expired GB2068002B (en) 1980-01-25 1981-01-07 Plasminogen preparation and their production

Country Status (5)

Country Link
CH (1) CH650273A5 (en)
DE (1) DE3102217A1 (en)
FR (1) FR2474313A1 (en)
GB (1) GB2068002B (en)
SE (2) SE459783B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3119157A1 (en) * 1981-05-14 1982-12-09 Behringwerke Ag, 3550 Marburg METHOD FOR PRODUCING PLASMINOGEN AND THEREFORE PRODUCED
ES2057191T5 (en) * 1989-01-13 2003-05-01 Mitsubishi Pharma Corp PRODUCTION METHOD FOR A COMPOSITION CONTAINING PROTEINS.
AT402367B (en) * 1990-10-11 1997-04-25 Immuno Ag PHARMACEUTICAL PREPARATION BASED ON LYS PLASMINOGEN

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3066079A (en) * 1959-09-18 1962-11-27 American Cyanamid Co Methods for purifying plasminogen
US3865692A (en) * 1974-01-11 1975-02-11 Abbott Lab Method for making highly potent plasminogen
FR2347048A2 (en) * 1976-04-07 1977-11-04 Choay Sa COMPOSITIONS CONSTITUTED BY PLASMINOGEN-TYPE COMPOUNDS, ESPECIALLY OF PLACENTARY ORIGIN, PROCESS FOR OBTAINING THESE COMPOSITIONS, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOSITIONS

Also Published As

Publication number Publication date
FR2474313A1 (en) 1981-07-31
SE8803798D0 (en) 1988-10-24
SE8100393L (en) 1981-07-26
DE3102217C2 (en) 1987-02-12
FR2474313B1 (en) 1984-02-10
DE3102217A1 (en) 1981-11-26
SE459783B (en) 1989-08-07
SE8803798L (en) 1988-10-24
GB2068002A (en) 1981-08-05
CH650273A5 (en) 1985-07-15

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19950107