GB2039276B - Trans-2-substituted-amido-hexahydrobenzo (a) quinolizines - Google Patents

Trans-2-substituted-amido-hexahydrobenzo (a) quinolizines

Info

Publication number
GB2039276B
GB2039276B GB7939941A GB7939941A GB2039276B GB 2039276 B GB2039276 B GB 2039276B GB 7939941 A GB7939941 A GB 7939941A GB 7939941 A GB7939941 A GB 7939941A GB 2039276 B GB2039276 B GB 2039276B
Authority
GB
United Kingdom
Prior art keywords
quinolizines
hexahydrobenzo
amido
trans
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7939941A
Other versions
GB2039276A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of GB2039276A publication Critical patent/GB2039276A/en
Application granted granted Critical
Publication of GB2039276B publication Critical patent/GB2039276B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB7939941A 1978-11-20 1979-11-19 Trans-2-substituted-amido-hexahydrobenzo (a) quinolizines Expired GB2039276B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96228678A 1978-11-20 1978-11-20

Publications (2)

Publication Number Publication Date
GB2039276A GB2039276A (en) 1980-08-06
GB2039276B true GB2039276B (en) 1983-02-16

Family

ID=25505662

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7939941A Expired GB2039276B (en) 1978-11-20 1979-11-19 Trans-2-substituted-amido-hexahydrobenzo (a) quinolizines

Country Status (6)

Country Link
JP (1) JPS5572189A (en)
CA (1) CA1118422A (en)
DE (1) DE2946613C2 (en)
FR (1) FR2441614A1 (en)
GB (1) GB2039276B (en)
IL (1) IL58680A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE51467B1 (en) * 1980-08-28 1986-12-24 Wyeth John & Brother Ltd Benzoquinolizines
US4992446A (en) * 1989-09-05 1991-02-12 G. D. Searle & Co. Tricyclic quinolizine amides
JP2018521021A (en) 2015-06-11 2018-08-02 バジリア・ファルマスーチカ・インターナショナル・アーゲーＢａｓｉｌｅａ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ａｇ Efflux pump inhibitors and their therapeutic use

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA940930A (en) * 1969-12-22 1974-01-29 John W. Van Dyke 2-substituted aminohexahydrobenzo (a) quinolizine derivatives
US3634431A (en) * 1969-12-22 1972-01-11 Miles Lab Acylated and alkylated derivatives of 2-aminohexahydrobenzo(a)quinolizines
GB1513824A (en) * 1975-05-22 1978-06-14 Wyeth John & Brother Ltd 1,3,4,6,7,11b-hexahydro-2h-benzo(a)quinolizine derivative
GB1593146A (en) * 1976-11-05 1981-07-15 Beecham Group Ltd Octahydro-quinolizinyl benzamide derivatives

Also Published As

Publication number Publication date
JPS5572189A (en) 1980-05-30
CA1118422A (en) 1982-02-16
FR2441614B1 (en) 1983-09-09
GB2039276A (en) 1980-08-06
DE2946613C2 (en) 1983-08-11
JPS5716112B2 (en) 1982-04-02
IL58680A (en) 1984-01-31
FR2441614A1 (en) 1980-06-13
IL58680A0 (en) 1980-02-29
DE2946613A1 (en) 1980-05-22

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19971119