FR2441614A1 - NEW TRANS-2- (AMIDO SUBSTITUTE) -HEXAHYDROBENZO (A) QUINOLIZINES AND MEDICAMENTS CONTAINING THEM - Google Patents

NEW TRANS-2- (AMIDO SUBSTITUTE) -HEXAHYDROBENZO (A) QUINOLIZINES AND MEDICAMENTS CONTAINING THEM

Info

Publication number
FR2441614A1
FR2441614A1 FR7928496A FR7928496A FR2441614A1 FR 2441614 A1 FR2441614 A1 FR 2441614A1 FR 7928496 A FR7928496 A FR 7928496A FR 7928496 A FR7928496 A FR 7928496A FR 2441614 A1 FR2441614 A1 FR 2441614A1
Authority
FR
France
Prior art keywords
amido
substitute
quinolizines
hexahydrobenzo
medicaments containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7928496A
Other languages
French (fr)
Other versions
FR2441614B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Miles Laboratories Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miles Laboratories Inc filed Critical Miles Laboratories Inc
Publication of FR2441614A1 publication Critical patent/FR2441614A1/en
Application granted granted Critical
Publication of FR2441614B1 publication Critical patent/FR2441614B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'INVENTION A TRAIT AU DOMAINE DE LA CHIMIE PHARMACEUTIQUE. ELLE CONCERNE DE NOUVELLES TRANS-2-(AMIDO SUBSTITUE)-HEXAHYDROBENZOAQUINOLIZINES DE FORMULE: (CF DESSIN DANS BOPI) LES COMPOSES DE L'INVENTION ET LEURS SELS D'ADDITION D'ACIDES NON TOXIQUES ACCEPTABLES DU POINT DE VUE PHARMACOLOGIQUE SONT UTILES COMME AGENTS ANTI-HYPERTENSIFS.THE INVENTION RELATES TO THE FIELD OF PHARMACEUTICAL CHEMISTRY. IT CONCERNS NEW TRANS-2- (SUBSTITUTE AMIDO) -HEXAHYDROBENZOAQUINOLIZINES OF FORMULA: (CF DRAWING IN BOPI) THE COMPOUNDS OF THE INVENTION AND THEIR ADDITIONAL SALTS OF NON-TOXIC ACIDS ACCEPTABLE FROM THE PHARMACOLOGICAL POINT OF VIEW COMME USEFUL ANTI-HYPERTENSIFS.

FR7928496A 1978-11-20 1979-11-19 NEW TRANS-2- (AMIDO SUBSTITUTE) -HEXAHYDROBENZO (A) QUINOLIZINES AND MEDICAMENTS CONTAINING THEM Granted FR2441614A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US96228678A 1978-11-20 1978-11-20

Publications (2)

Publication Number Publication Date
FR2441614A1 true FR2441614A1 (en) 1980-06-13
FR2441614B1 FR2441614B1 (en) 1983-09-09

Family

ID=25505662

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7928496A Granted FR2441614A1 (en) 1978-11-20 1979-11-19 NEW TRANS-2- (AMIDO SUBSTITUTE) -HEXAHYDROBENZO (A) QUINOLIZINES AND MEDICAMENTS CONTAINING THEM

Country Status (6)

Country Link
JP (1) JPS5572189A (en)
CA (1) CA1118422A (en)
DE (1) DE2946613C2 (en)
FR (1) FR2441614A1 (en)
GB (1) GB2039276B (en)
IL (1) IL58680A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0416520A1 (en) * 1989-09-05 1991-03-13 G.D. Searle & Co. Tricyclic quinolizine amides

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE51467B1 (en) * 1980-08-28 1986-12-24 Wyeth John & Brother Ltd Benzoquinolizines
US10464896B2 (en) 2015-06-11 2019-11-05 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634431A (en) * 1969-12-22 1972-01-11 Miles Lab Acylated and alkylated derivatives of 2-aminohexahydrobenzo(a)quinolizines
US4076820A (en) * 1975-05-22 1978-02-28 John Wyeth & Brother, Limited Benzoquinolizines and hypotensive compositions containing them
FR2370051A1 (en) * 1976-11-05 1978-06-02 Beecham Group Ltd NEW SUBSTITUTE BENZAMIDES FOR USE AS MEDICINAL PRODUCTS

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA940930A (en) * 1969-12-22 1974-01-29 John W. Van Dyke 2-substituted aminohexahydrobenzo (a) quinolizine derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634431A (en) * 1969-12-22 1972-01-11 Miles Lab Acylated and alkylated derivatives of 2-aminohexahydrobenzo(a)quinolizines
US4076820A (en) * 1975-05-22 1978-02-28 John Wyeth & Brother, Limited Benzoquinolizines and hypotensive compositions containing them
FR2370051A1 (en) * 1976-11-05 1978-06-02 Beecham Group Ltd NEW SUBSTITUTE BENZAMIDES FOR USE AS MEDICINAL PRODUCTS

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EXBK/72 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0416520A1 (en) * 1989-09-05 1991-03-13 G.D. Searle & Co. Tricyclic quinolizine amides

Also Published As

Publication number Publication date
DE2946613A1 (en) 1980-05-22
IL58680A (en) 1984-01-31
CA1118422A (en) 1982-02-16
FR2441614B1 (en) 1983-09-09
JPS5572189A (en) 1980-05-30
JPS5716112B2 (en) 1982-04-02
GB2039276B (en) 1983-02-16
IL58680A0 (en) 1980-02-29
GB2039276A (en) 1980-08-06
DE2946613C2 (en) 1983-08-11

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Legal Events

Date Code Title Description
ER Errata listed in the french official journal (bopi)
ST Notification of lapse