GB2034037A - Decompression Bubble Detector - Google Patents
Decompression Bubble Detector Download PDFInfo
- Publication number
- GB2034037A GB2034037A GB7934423A GB7934423A GB2034037A GB 2034037 A GB2034037 A GB 2034037A GB 7934423 A GB7934423 A GB 7934423A GB 7934423 A GB7934423 A GB 7934423A GB 2034037 A GB2034037 A GB 2034037A
- Authority
- GB
- United Kingdom
- Prior art keywords
- transducer
- decompression
- bubble detector
- detector
- decompression bubble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/02—Analysing fluids
- G01N29/032—Analysing fluids by measuring attenuation of acoustic waves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/22—Details, e.g. general constructional or apparatus details
- G01N29/24—Probes
- G01N29/2456—Focusing probes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/22—Details, e.g. general constructional or apparatus details
- G01N29/28—Details, e.g. general constructional or apparatus details providing acoustic coupling, e.g. water
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/34—Generating the ultrasonic, sonic or infrasonic waves, e.g. electronic circuits specially adapted therefor
- G01N29/348—Generating the ultrasonic, sonic or infrasonic waves, e.g. electronic circuits specially adapted therefor with frequency characteristics, e.g. single frequency signals, chirp signals
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/02—Indexing codes associated with the analysed material
- G01N2291/024—Mixtures
- G01N2291/02433—Gases in liquids, e.g. bubbles, foams
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/02—Indexing codes associated with the analysed material
- G01N2291/024—Mixtures
- G01N2291/02475—Tissue characterisation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/10—Number of transducers
- G01N2291/101—Number of transducers one transducer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/10—Number of transducers
- G01N2291/106—Number of transducers one or more transducer arrays
Abstract
A decompression bubble detector comprises a pulsed ultra-sound transmitter/receiver which is scanned across a cross-section of tissue and the total number of pulse echoes received in a preselected time interval (e.g. 1.5 sec.) is counted. Changes in the total number of pulse echoes counted in successive time intervals are used to monitor the decompression. A single transducer 1 is scanned by means of a driven eccentric cam 4 and a cam follower 6. A sin/cos potentiometer 3 generates a signal related to the angular position of the transducer 1 connected to a delay 20 so that pulse counting can be arranged to coincide with the passage of the transducer 1 across the target. A fixed number is subtracted at 25 from each count, and the difference is recorded by pen recorder 28. <IMAGE>
Description
SPECIFICATION
Improvements in or Relating to Decompression
Bubble Detectors
The invention relates to the detection of bubble formation in a diver's tissues during decompression procedures.
The symptoms of decompression sickness have been attributed to both moving and stationary bubbles. A decompression detector should ideally therefore be capable of responding to both types of bubble.
Bubble formation has been studied with ultrasound which offers a powerful tool for decompression monitoring because of the large attenuation of an ultra-sound beam by a gas bubble. Several ultra-sound transmission techniques have been used, however methods based on reflection of ultra-sound have been most widely used since gas bubbles in tissues are highly efficient reflectors. The most extensively used reflection technique has employed Doppler shift measurements to detect moving bubbles.
The Doppler systems suffer two major disadvantages in being able to detect only moving and hence intravascular bubbles and being unable to see the formation of bubbles within the crosssection of tissue under observation.
An alternative method is the pulse-echo imaging method which detects both moving and stationary bubbles within a cross-section of tissue. By careful analysis the distribution and movement of any bubbles found can be studied.
The analysis of the ultra-sound images has required a considerable time, and this method has not therefore been a suitable direct monitor of decompression procedures.
The object of the invention is to produce a detector which quickly responds to both stationary and moving bubbles in a cross-section of tissue.
The invention consists of an ultrasonic detector for detecting decompression bubbles in human tissue comprising a pulsed ultrasonic transmitter, means to scan the transmitter across an area of tissue, a detector to record echoes reflected from said scanned area of tissue, a counter to count the number of echoes recorded by said detector in a preselected time interval, and a display means whereby the numbers of echoes recorded in successive preselected time intervals can be displayed.
In one advantageous arrangement a single ultrasonic transducer is used for both transmission and detection. Preferably the transducer is circular in cross-section and is
provided with a plano-concave lens mounted
directly on one face of the transducer whereby the
ultrasonic energy is focused on the said area of tissue. Conveniently said transducer is scanned by
means of an eccentric cam and follower drive
system. Advantageously the transducer is held in
a fixed position relative to a target and is
acoustically coupled thereto by water or an iso
osmotic salt solution. In an alternative
arrangement a transducer array comprising a plurality of transducer elements is used for transmission and detection, scanning being achieved by electronically switching from one of said elements to the next.Preferably the transducer should operate at a frequency between 2.5 and 8 MHz to provide suitable resolution plus penetration. Advantageously the minimum pulse repetition rate used is a minimum consistent with the area being studied.
In a convenient arrangement a trigger pulse initiated by the scanning means starts the counter via a delay unit, the delay being set so that the counting coincides with the passage of the transducer scan across the target.
The number of pulse echoes recorded from a typical tissue cross-section in a counting time of 1.5 sec using a pulse repetition frequency of 2 kHz is typically about 10,000. In order that changes in the count can be readily observed this high base-line count is advantageously reduced by subtracting a preselectable number from the count. In a convenient arrangement the numbers of echoes recorded in successive time intervals less said preselected number are displayed by means of a pen recorder.
The invention will now be described by way of example only with reference to the accompanying a'ravings of which~ Figure 1 is a block diagram of the ultra-sound bubble detector;
Figure 2 shows the output recorded by the detector scanning a guinea pig hind leg after a saturation dive to 8.3 bar (120 psig) air; and
Figure 3 is a block diagram of a transducer array for use in the ultra-sound bubble detector.
The decompression bubble detector shown schematically in Figure 1 uses an integrating pulse-echo technique. A single element circular
PZT-5A transducer probe 1 of 5 mm diameter with an operating frequency of 8 MHz is provided with a plano-concave focusing lens 2. The focal length of the lens is 20 mm. The transducer 1 is mechanically linked to a sin/cos potentiometer 3 and a follower drive system. A simple sector scan of about 1 Hz is provided by means of an eccentric cam 4 driven by a motor 5 and a cam follower 6. The sin/cos potentiometer 3 generates a sinusoidal signal related to the angular position of the transducer probe 1 which is used to activate a trigger which initiates pulse counting.
The transducer 1 is normally positioned 15 mm behind the target and is acoustically coupled to the target by water or an iso-osmotic salt solution. A time-base generator 7 and a pulse repetition frequency control circuit 8 provide a transmitter trigger which in turn provides a pulse to a transmitter 9 wherein a thyristor discharges pre-loaded capacitors to the transducer 1 via a HF cable 10. The transducer 1 is chosen to operate at a frequency of 8 MHz so as to provide suitable resolution plus penetration. At 8 MHz, the tissue penetration is about 4 to 5 cm. For scanning across a human thigh a frequency of about 2.5
MHz would be used so as to be able to scan a similar section across the thigh. The pulse repetition frequency of the transmitter 9 is chosen to be 2 kHz.A CRT monitor 11 is provided to monitor the transmitted pulses because any instability which might develop severely affects the reliability of the detector. The CRT monitor 11 is connected to the HF cable 10 between the transmitter 9 and the transducer 1 at a connection 12.
The transducer 1 is also used as the detection element for reflected echo pulses. Echoes are converted by the transducer 1 into electrical signals which are connected to a receiver 13.
The receiver 13 includes a 0--80 dB attenuator and an amplifier stage. The receiver output is demodulated by a demodulator 14 and connected to a final amplifier 1 5. The output from the final amplifier 1 5 is provided as an input to an echo display CRT 16, and after shaping by a pulse shaper circuit 17 as an input to a gate and control circuit 1 8 which controls the counting of the echo pulses. The received echo pattern is displayed, firstly to check that the desired penetration is attained and secondly so that the correct level of signal suppression and swept gain compensation is employed. A trigger pulse is generated by a trigger circuit 19 connected to the sin/cos potentiometer 3 so as initiate the echo counting cycle via a delay circuit 20, shown as part of the gate and control circuit 18.The delay of the circuit 20 is set so that the counting coincides with the passage of the scan of the transducer 1 across the target. The control unit 18 has a stored time reference which determines the length of time the gate 21 of the gate and control circuit 1 8 is open allowing pulses from the pulse shaper 17 to be transmitted to the output 22 of the gate and control circuit 18. On production of a trigger pulse from the trigger circuit 19 the gate 21 is opened and a clock 23 starts to count into a timing circuit 24. When the count in the timing circuit 24 is equal to the stored time reference the control circuit 18 closes the gate 21.
In order that the bubble detector will be sensitive to small increases in the total number of echoes, the echo pulses at the output 22 of the gate and control circuit 18 are connected to a subtraction circuit 25 where a fixed number is subtracted so as to leave a small remainder representing the base-line count. Any increase from the base-line count should then be more clearly observable. The appearance of stationary bubbles will be seen as an increase in the echo count, whilst bubbles passing through the plane of scan will be seen as an increase in the variability of the count. The number subtracted is determined by inspection of the total number, typically about 10,000 using a pulse repetition frequency of 2k Hz and a counting time of 1.5 sec.
After subtraction the remaining pulses are fed to a digital count display unit 26 and are also passed through a divide-by-ten circuit (not shown) to a
Digital-to-Analogue (D/A) converter 27. The D/A
converter 27 is such as to accept 256 digital
levels and the divide-by-ten circuit is used so that the echo remainder can be set at approximately
250 (typically 1/40 of the total echo count) and a ten-fold increase in the echo remainder can be
accommodated. Initially with Zero subtraction the
digital display 26 registers the total number of echoes. From observation of this number, the
number to be subtracted by the subtraction circuit 25 so as to leave a remainder of about 250 is stored in the gate and control circuit 18. From the
D/A converter 27 the analogue signal representing 1/10th the echo remainder is fed to a pen recorder 28.
In an experimental arrangement to test the decompression bubble detector a male guinea pig was anaesthetised. The hind limbs were shaved and all remaining hair removed with a depilatory cream. Electrocardiogram (ECG) electrodes were attached, one at the back of the neck and one positioned directly over the heart. The guinea pig was then placed inside a perspex holder designed so that the hind limbs were readily accessible to the ultra-sound transducer. The holder was then fixed into a perspex scanning tank and a brass framework carrying the transducer, the sin/cos potentiometer and the drive system was positioned behind the guinea pig. The position of the transducer was adjusted so as to be 1 5 mm behind the left hind limb, approximately midway between the knee and ankle and with the leg central with respect to the axis of the transducer.
The entire scanning assembly was placed inside a 36 litre decompression chamber. The scanning tank was filled with the iso-osmotic solution comprising 0.7% NaCI, 0.035% KCI and 0.03% MgSO4. 7H2O w/v in water so that the test limb and transducer were completely covered. The salt solution had been preheated to 370C and was maintained at 370C throughout the experiment by a thermostatically controlled heating element located in the bottom of the scanning tank. Soda lime scrubbers were placed inside the chamber and the chamber sealed. An internal fan was provided to ensure adequate mixing and scrubbing of the chamber gases. The pressure was then increased using medical grade compressed air to a pressure of 8.3 bar (120 psig) over 1 min. This pressure was maintained for 90 mins, a period sufficient for saturation to be reached. The ambient chamber temperature throughout the experiment was 30+1 OC.
The ultra-sound system was switched on 5 min before decompression and adjusted to a gain of 75 dB and a pulse repetition rate of 2 kHz. Swept gain was set to compensate for the attenuation of echoes from deep structures due to absorption.
The signal supression was set to eliminate small amplitude, unwanted echo signals.
With these settings the total echo count, with a counting interval of 1 sec, was approximately 4,900. Accordingly the subtraction level was set at 4400 to give a zero base-line corresponding to a count of 500 with a full scale deflection corresponding to a count of 2560. When the ultra-sound system was set the guinea pig was decompressed to 0 bar (surface) in 70 sec.
Figure 2 shows the echo count 201 as a function of time (increasing to the left) as a result of applying the pressure cycle 202 to the guinea pig. The Figure also shows the times of ECG changes indicated by a-g. The count level did not show any change until 3 min 10 sec after the first decompression 203. A rapid increase 204 of about 100% occurred. No change was observed in the ecg until 4 min 10 sec post decompression (a) when some Twave elevation occurred. The guinea pig was held at the surface until 5 min 30 sec post decompression indicated by 205. The ecg demonstrated increasingly severe cardiac arrhythamias over this period and the count level remained elevated with a large variation. At 5 min 30 sec post decompression the guinea pig was recompressed (206) to 8.3 bar in 85 sec.The count level fell rapidly (207) in response to the increase in pressure and the ecg returned to a normal form (b). During the period at pressure (208) some periods of Twave elevation (c) were observed and the count level showed bursts of variability outside the normal. At the time d the ecg reverted to normal. After about 5 mins at 8.3 bar (208) the guinea pig was again decompressed (209) to the surface in 70 secs.
This time the count level began to rise almost immediately (210), although at a slightly slower rate than previously. Again coupled with this increase in count level there was a marked increase in variability. The onset of ecg changes (e) was marked by gross abnormalities. The guinea pig was maintained at the surface (211) for 5 mins during which the heart beat at half the normal frequency (f) and then there developed a low frequency ventricular rhythm with no detectable atrial beat (g). The guinea pig was then recompressed (212) to 8.9 bar in 100 secs.
Again the effect of recompression was to rapidly reduce the count to the base level. However the ecg did not return to normal, even after 6 mins at 8.9 bar, although the count remained constant at the base level. The final decompression (213) produced an immediate sharp rise 214 in the count rate of nearly 500%. Following this, cardiac activity ceased.
The experiment indicates that the bubble detector records increases in bubble count which follow the pressure profile and occur before changes in the ecg. In addition the degree of rise in the count level was directly related to the severity of the decompressions. The form of the output from the detector is particularly easy to interpret, unlike the typical output from a Doppler system.
In an alternative arrangement as shown in
Figure 3 the single mechanically scanned transducer is replaced by a plurality of transducer elements 301 forming a transducer array 302, with scanning being achieved by electronically switching from one element to the next by the switch circuit 303.
Two possible areas of application for this technique are the detection of vestibular bubble formation and the detection of bubble formation within bone tissue. At present vestibular decompression sickness is the most common manifestation following deep oxy-helium dives.
Owing to the efficiency of decompression therapy bubble formation is thought to be the cause.
However such bubble formation has never been observed and indeed with current Doppler techniques could not be seen, the second possibility affords an opportunity of detecting the critical insult to bone tissue and thus, in principle, a a means of preventing dysbaric osteonecrosis.
Currently this condition can only be diagnosed by radio-graphical methods after deposition of calcium has occurred.
Other methods of processing the ultrasonic pulse echoes within the scope of the invention will be apparent to those skilled in the art.
Claims (10)
1. A decompression bubble detector for detecting the decompression bubbles in human tissue comprising a pulsed ultrasonic transmitter, means to scan the transmitter across an area of tissue, a detector to record echoes reflected from said scanned area of tissue, a counter to count the number of echoes recorded by said detector in a preselected time interval, and a display means whereby the numbers of echoes recorded in successive preselected time intervals can be displayed.
2. A decompression bubble detector as claimed in claim 1 wherein a single ultrasonic transducer is used for both transmission and detection.
3. A decompression bubble detector as claimed in claim 2 wherein the transducer is circular in cross-section and is provided with a plano-concave lens mounted directly on one face thereof whereby the ultrasonic energy is focused on the said area of tissue.
4. A decompression bubble detector as claimed in claim 2 or 3 wherein the transducer is scanned by means of an eccentric cam and follower drive system.
5. A decompression bubble detector as claimed in any one of claims 2 to 4 wherein the transducer is held in a fixed position relative to a target and is acoustically coupled thereto by water or an iso-osmotic salt solution.
6. A decompression bubble detector as claimed in claim 1 wherein there is provided a transducer array comprising a plurality of transducer elements for transmission and detection, scanning being achieved by electronically switching from one of said elements to the next.
7. A decompression bubble detector as claimed in any one preceding claim wherein the transmitter operates at a frequency between 2.5 and 8 MHz to provide suitable resolution plus penetration.
8. A decompression bubble detector as claimed in any one preceding claim wherein a trigger pulse initiated by the scanning means starts a counter via a delay unit, the delay being set so that the counting coincides with the passage of the transducer scan across the target.
9. A decompression bubble detector as claimed in any one preceding claim wherein the numbers of echoes recorded in successive time intervals less a preselected number are displayed by means of a pen recorder.
10. A decompression bubble detector substantially as described with reference to
Figures 1 and 2 of the accompanying drawings.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7934423A GB2034037B (en) | 1978-10-11 | 1979-10-04 | Decompression bubble detetor |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7840103 | 1978-10-11 | ||
GB7934423A GB2034037B (en) | 1978-10-11 | 1979-10-04 | Decompression bubble detetor |
Publications (2)
Publication Number | Publication Date |
---|---|
GB2034037A true GB2034037A (en) | 1980-05-29 |
GB2034037B GB2034037B (en) | 1983-07-20 |
Family
ID=26269146
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB7934423A Expired GB2034037B (en) | 1978-10-11 | 1979-10-04 | Decompression bubble detetor |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB2034037B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2187840A (en) * | 1986-03-11 | 1987-09-16 | Wolf Gmbh Richard | Method and apparatus for detecting cavitations during medical application of high sonic energy |
-
1979
- 1979-10-04 GB GB7934423A patent/GB2034037B/en not_active Expired
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2187840A (en) * | 1986-03-11 | 1987-09-16 | Wolf Gmbh Richard | Method and apparatus for detecting cavitations during medical application of high sonic energy |
FR2597326A1 (en) * | 1986-03-11 | 1987-10-23 | Wolf Gmbh Richard | METHOD FOR IDENTIFYING POSSIBLE TISSUE LESIONS DURING THE MEDICAL APPLICATION OF HIGH ENERGY SOUND. |
GB2187840B (en) * | 1986-03-11 | 1990-01-10 | Wolf Gmbh Richard | Method and apparatus for detecting cavitations during medical application of high sonic energy |
Also Published As
Publication number | Publication date |
---|---|
GB2034037B (en) | 1983-07-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PCNP | Patent ceased through non-payment of renewal fee |