GB2016454A - N-(2-aminocycloheptyl) acylanilides - Google Patents

N-(2-aminocycloheptyl) acylanilides

Info

Publication number
GB2016454A
GB2016454A GB7907226A GB7907226A GB2016454A GB 2016454 A GB2016454 A GB 2016454A GB 7907226 A GB7907226 A GB 7907226A GB 7907226 A GB7907226 A GB 7907226A GB 2016454 A GB2016454 A GB 2016454A
Authority
GB
United Kingdom
Prior art keywords
alkyl
acylanilides
aminocycloheptyl
hydrogen
alkenylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7907226A
Other versions
GB2016454B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/885,515 external-priority patent/US4156014A/en
Priority claimed from US05/910,748 external-priority patent/US4172898A/en
Priority claimed from US05/912,643 external-priority patent/US4169156A/en
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB2016454A publication Critical patent/GB2016454A/en
Application granted granted Critical
Publication of GB2016454B publication Critical patent/GB2016454B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the formula <IMAGE> [wherein p is zero or one; Q is oxygen or sulphur; R is alkyl, cycloalkyl, vinyl, ethoxy or methoxymethyl. R1 is hydrogen, alkyl, dimethylaminoalkyl, aralkyl or alkenylmethyl; and Y and Z are each hydrogen, halogen, trifluoromethyl, alkyl, alkoxy or azido; and salts thereof] have anti-depressant activity.
GB7907226A 1978-03-13 1979-03-01 N-(2-aminocycloheptyl) acylanilides Expired GB2016454B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US05/885,515 US4156014A (en) 1977-03-21 1978-03-13 N-(2-aminocycloheptyl)alkanoylanilides and in the treatment of depression
US05/910,748 US4172898A (en) 1977-03-21 1978-05-30 N-(2-aminocycloheptyl)acylanilides
US05/912,643 US4169156A (en) 1977-03-21 1978-06-05 N-(2-aminocycloheptyl)alkanoylanilides

Publications (2)

Publication Number Publication Date
GB2016454A true GB2016454A (en) 1979-09-26
GB2016454B GB2016454B (en) 1982-07-07

Family

ID=27420519

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7907226A Expired GB2016454B (en) 1978-03-13 1979-03-01 N-(2-aminocycloheptyl) acylanilides

Country Status (9)

Country Link
JP (1) JPS54128546A (en)
AU (1) AU523351B2 (en)
CH (1) CH638488A5 (en)
DE (1) DE2905634A1 (en)
FR (1) FR2423220A2 (en)
GB (1) GB2016454B (en)
IT (1) IT1113032B (en)
NL (1) NL7901761A (en)
SE (1) SE446263B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3510492A (en) * 1968-05-13 1970-05-05 Upjohn Co 2-anilino and 2-anilinomethyl cycloalkylamines

Also Published As

Publication number Publication date
FR2423220B2 (en) 1981-02-27
IT1113032B (en) 1986-01-20
IT7920756A0 (en) 1979-03-05
JPS54128546A (en) 1979-10-05
CH638488A5 (en) 1983-09-30
DE2905634A1 (en) 1979-09-27
SE446263B (en) 1986-08-25
FR2423220A2 (en) 1979-11-16
NL7901761A (en) 1979-09-17
AU523351B2 (en) 1982-07-22
AU4415379A (en) 1979-09-20
SE7902148L (en) 1979-09-14
GB2016454B (en) 1982-07-07

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee