GB201300054D0 - Methods for cartilage repair using TFGBETA and FGF -2 - Google Patents

Methods for cartilage repair using TFGBETA and FGF -2

Info

Publication number
GB201300054D0
GB201300054D0 GBGB1300054.2A GB201300054A GB201300054D0 GB 201300054 D0 GB201300054 D0 GB 201300054D0 GB 201300054 A GB201300054 A GB 201300054A GB 201300054 D0 GB201300054 D0 GB 201300054D0
Authority
GB
United Kingdom
Prior art keywords
tfgbeta
fgf
methods
cartilage repair
cartilage
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GBGB1300054.2A
Other versions
GB2494357A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Swansea University
Original Assignee
Swansea University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Swansea University filed Critical Swansea University
Publication of GB201300054D0 publication Critical patent/GB201300054D0/en
Publication of GB2494357A publication Critical patent/GB2494357A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1841—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0655—Chondrocytes; Cartilage
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

The invention relates to a novel combination of growth factors that induce morphogenic changes in cartilage leading o maturation of the phenotype; and the use of these growth factors in culture medium and therapeutics for repairing damaged cartilage.
GB1300054.2A 2010-06-22 2011-06-20 Methods for cartilage repair using TFGBETA and FGF -2 Withdrawn GB2494357A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB201010422A GB201010422D0 (en) 2010-06-22 2010-06-22 Cartilage repair
PCT/GB2011/051144 WO2011161437A1 (en) 2010-06-22 2011-06-20 Methods for cartilage repair using tfgbeta and fgf - 2

Publications (2)

Publication Number Publication Date
GB201300054D0 true GB201300054D0 (en) 2013-02-20
GB2494357A GB2494357A (en) 2013-03-06

Family

ID=42582763

Family Applications (2)

Application Number Title Priority Date Filing Date
GB201010422A Ceased GB201010422D0 (en) 2010-06-22 2010-06-22 Cartilage repair
GB1300054.2A Withdrawn GB2494357A (en) 2010-06-22 2011-06-20 Methods for cartilage repair using TFGBETA and FGF -2

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB201010422A Ceased GB201010422D0 (en) 2010-06-22 2010-06-22 Cartilage repair

Country Status (2)

Country Link
GB (2) GB201010422D0 (en)
WO (1) WO2011161437A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3660018A4 (en) * 2017-07-27 2021-04-21 Jiangsu Hengrui Medicine Co., Ltd. Piperazine heteroaryl derivative, preparation method therefor and use of same in medicine

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8017394B2 (en) * 2004-10-01 2011-09-13 Isto Technologies, Inc. Method for chondrocyte expansion with phenotype retention
JP4044579B2 (en) * 2005-08-02 2008-02-06 株式会社Ｐｇリサーチ Artificial cartilage tissue
JP6156968B2 (en) * 2008-11-25 2017-07-05 ティシュージーン，インク． Priming cell therapy

Also Published As

Publication number Publication date
GB201010422D0 (en) 2010-08-04
GB2494357A (en) 2013-03-06
WO2011161437A1 (en) 2011-12-29

Similar Documents

Publication Publication Date Title
IL273159A (en) Culture medium composition, and method for culturing cell or tissue using said composition
EP2421956A4 (en) Compositions and methods for deriving or culturing pluripotent cells
EP2257176A4 (en) Compositions and methods for cartilage repair
SG11201405875PA (en) Methods and compositions for regenerating and repairing damaged tissue using nonviable irradiated or lyophilized pluripotent stem cells
MX2019002513A (en) Methods and compositions for consumables.
WO2011139688A3 (en) Methods for generating cardiomyocytes
EP2544609A4 (en) Apparatus and methods for bone repair
EP2795293A4 (en) Spectroscopic means and methods for identifying microorganisms in culture
EP2423302A4 (en) New serum-free medium for inducing pluripotent stem cells quickly with high efficiency and method using thereof
EP2734622A4 (en) Compositions and methods for re-programming cells without genetic modification for repairing cartilage damage
EP2608778A4 (en) Compositions and methods for treating bone defects
IL205616A (en) Compositions containing hepatocyte growth factors for use in the repair or regeneration of damaged myocardium
EP2550629A4 (en) Method and apparatus for managing files in an online account
EP2438161B1 (en) Method for producing induced pluripotent stem cells and method for culturing the same
IL212277A0 (en) Compositions for use in treating thymic stromal lymphopoietin (tslp)-mediated conditions
DK2403994T3 (en) APPARATUS AND METHOD FOR MANAGING RAILWAYS
GB201011269D0 (en) Apparatus and methods for maintenance and repair of vessels
AP3121A (en) Biomass stove apparatus and method for its use
EP2448957A4 (en) Methods and compositions for affecting the differentiation of clostridia in culture
EP2399989A4 (en) Culture medium and method for inducing differentiation into adipocytes
EP2616085A4 (en) Compositions and method for promoting musculoskeletal repair
GB201120187D0 (en) Method and apparatus for repair of subsidence damage
HUE050574T2 (en) Compositions and methods for inducing or enhancing connective tissue repair
GB201300054D0 (en) Methods for cartilage repair using TFGBETA and FGF -2
IL217282A0 (en) Methods and apparatus for improving plant growth

Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)