GB2009160A - Prostacyclin Derivatives - Google Patents

Prostacyclin Derivatives

Info

Publication number
GB2009160A
GB2009160A GB7844527A GB7844527A GB2009160A GB 2009160 A GB2009160 A GB 2009160A GB 7844527 A GB7844527 A GB 7844527A GB 7844527 A GB7844527 A GB 7844527A GB 2009160 A GB2009160 A GB 2009160A
Authority
GB
United Kingdom
Prior art keywords
deoxy
pgf1
alpha
epoxy
less
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7844527A
Other versions
GB2009160B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/857,203 external-priority patent/US4125713A/en
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB2009160A publication Critical patent/GB2009160A/en
Application granted granted Critical
Publication of GB2009160B publication Critical patent/GB2009160B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

Certain prostacyclin derivatives having desirable pharmacological properties, which are the less or more a polar isomer of 9-deoxy-6,9 alpha -epoxy- 16,16-dimethyl-PGF1 and their methyl esters; the less or more polar isomer of 9-deoxy-6 epsilon ,9 alpha -epoxy-16-phenoxy- 17,18,19,20-tetranor-PGF1 and their methyl esters; the less or more polar isomer of 9-deoxy-6,9 alpha -epoxy-PGF1, n-butylamide; the various stereoisomers of 13,14-didehydro- PGI1 and its methyl ester; the less or more polar isomer of trans- DELTA <2>-PGI1, methyl ester; the less or more polar isomer of trans- DELTA <2>-16,16-dimethyl- PGI1 and their methyl esters; the more polar isomer of 9-deoxy-6 epsilon ,9 alpha -epoxy- 13,14-dihydro-PGF1; the less or more polar isomer of 9-deoxy-6 epsilon ,9 alpha -epoxy- 2,2-difluoro-16-phenoxy- 17,18,19,20-tetranor-PGF1, methyl ester; the less or more polar isomer of 9-deoxy-6 epsilon ,9 alpha -epoxy-15epi-16- phenoxy-17,18,19,20-tetranor-PGF1 and their methyl esters; the less or more polar isomer of 9-deoxy-6 epsilon ,9 alpha - epoxy-11-deoxy-10,11-didehydro-PGF1, methyl ester; (6S)-15-deoxy-15-oxo- 9-deoxy-6,9 alpha -epoxy-13,14-dihydro- PGF1, methyl ester; (6S)-9-Deoxy-6, 9 alpha -epoxy-(15R)-15-methyl-PGF1 and (6R) or (6S)-2,2-Difluor-9-deoxy- 6,9 alpha -epoxy-13,14-didehydro-PGF1, methyl ester.
GB7844527A 1977-12-05 1978-11-15 Prostacyclin derivatives Expired GB2009160B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/857,203 US4125713A (en) 1976-06-01 1977-12-05 Certain 5,6-dihydra-prostacyclin analogs

Publications (2)

Publication Number Publication Date
GB2009160A true GB2009160A (en) 1979-06-13
GB2009160B GB2009160B (en) 1983-04-27

Family

ID=25325440

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7844527A Expired GB2009160B (en) 1977-12-05 1978-11-15 Prostacyclin derivatives

Country Status (4)

Country Link
BE (1) BE871209R (en)
FR (1) FR2410652B2 (en)
GB (1) GB2009160B (en)
IE (1) IE48172B1 (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI71138C (en) * 1976-12-31 1986-11-24 Erba Farmitalia FOERFARANDE FOER FRAMSTAELLNING AV TERAPEUTISKT ACTIVE BISYCLISKA PROSTAGLANDINER
JPS5395958A (en) * 1977-01-31 1978-08-22 Ono Pharmaceut Co Ltd Prostaglandin analogues and process for their preparation

Also Published As

Publication number Publication date
FR2410652B2 (en) 1986-05-23
GB2009160B (en) 1983-04-27
IE48172B1 (en) 1984-10-17
FR2410652A2 (en) 1979-06-29
BE871209R (en) 1979-04-12
IE782403L (en) 1979-06-05

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee