GB2004278A - Pyrazolo[4,3-e]1,2,4-triazolo [4,3-c]pyrimidine derivatives - Google Patents

Pyrazolo[4,3-e]1,2,4-triazolo [4,3-c]pyrimidine derivatives

Info

Publication number
GB2004278A
GB2004278A GB7836516A GB7836516A GB2004278A GB 2004278 A GB2004278 A GB 2004278A GB 7836516 A GB7836516 A GB 7836516A GB 7836516 A GB7836516 A GB 7836516A GB 2004278 A GB2004278 A GB 2004278A
Authority
GB
United Kingdom
Prior art keywords
7alkyl
triazolo
pyrazolo
pyrimidine derivatives
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB7836516A
Other versions
GB2004278B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/833,103 external-priority patent/US4124764A/en
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB2004278A publication Critical patent/GB2004278A/en
Application granted granted Critical
Publication of GB2004278B publication Critical patent/GB2004278B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

New pyrazolo[4,3e]1,2,4-triazolo [4,3-c]pyrimidine derivatives which have the formula <IMAGE> wherein R1 is hydrogen, C1-7alkyl, phenyl-C1-7alkyl, cycloalkyl or hydroxy- C1-7alkyl; R2 is hydrogen or C1-7 alkyl; R3 is C1-7alkyl, cycloalkyl or hydroxy-C1-7alkyl; and X is sulfur or oxygen, are useful as anti- inflammatory agents.
GB7836516A 1977-09-13 1978-09-12 Pyrazolo(4,3-e)1,2,4-triazolo(4,3-c)-pyrimidine derivatives Expired GB2004278B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/833,103 US4124764A (en) 1976-04-21 1977-09-13 Meso-ionic didehydro derivatives of 1,7-dehydro-1-substituted-3H-pyrazolo[4,]-1,2,4-triazolo[4,3-c]pyrimidine-3-thiones and 3-ones

Publications (2)

Publication Number Publication Date
GB2004278A true GB2004278A (en) 1979-03-28
GB2004278B GB2004278B (en) 1982-01-13

Family

ID=25263436

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7836516A Expired GB2004278B (en) 1977-09-13 1978-09-12 Pyrazolo(4,3-e)1,2,4-triazolo(4,3-c)-pyrimidine derivatives

Country Status (13)

Country Link
JP (1) JPS5452098A (en)
AU (1) AU3914178A (en)
BE (1) BE870456A (en)
CA (1) CA1095907A (en)
DE (1) DE2838029A1 (en)
DK (1) DK402178A (en)
FR (1) FR2402658A1 (en)
GB (1) GB2004278B (en)
HU (1) HU176023B (en)
IT (1) IT1099031B (en)
NL (1) NL7809035A (en)
NO (1) NO783086L (en)
SE (1) SE7809601L (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053474A (en) * 1976-04-21 1977-10-11 E. R. Squibb & Sons, Inc. Pyrazolo[4,3-e][1,2,4]triazolo[4,3-c]pyrimidine

Also Published As

Publication number Publication date
BE870456A (en) 1979-03-13
IT1099031B (en) 1985-09-18
GB2004278B (en) 1982-01-13
IT7827559A0 (en) 1978-09-12
NO783086L (en) 1979-03-14
HU176023B (en) 1980-11-28
AU3914178A (en) 1980-02-28
CA1095907A (en) 1981-02-17
DK402178A (en) 1979-03-14
SE7809601L (en) 1979-03-14
DE2838029A1 (en) 1979-03-22
NL7809035A (en) 1979-03-15
FR2402658A1 (en) 1979-04-06
JPS5452098A (en) 1979-04-24

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee