GB2000186A - Method of producing antibodies in vitro - Google Patents

Method of producing antibodies in vitro

Info

Publication number
GB2000186A
GB2000186A GB7826758A GB7826758A GB2000186A GB 2000186 A GB2000186 A GB 2000186A GB 7826758 A GB7826758 A GB 7826758A GB 7826758 A GB7826758 A GB 7826758A GB 2000186 A GB2000186 A GB 2000186A
Authority
GB
United Kingdom
Prior art keywords
cells
large amounts
cell hybrids
fused cell
vitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB7826758A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wistar Institute of Anatomy and Biology
Original Assignee
Wistar Institute of Anatomy and Biology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wistar Institute of Anatomy and Biology filed Critical Wistar Institute of Anatomy and Biology
Publication of GB2000186A publication Critical patent/GB2000186A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Abstract

Continuous cell lines of genetically stable fused cell hybrids capable of producing large amounts of monoclonal antibodies against specific viruses and their antigenic determinants have been developed. The cell lines are fused cell hybrids between viral antibody producing cells and myeloma cells. Fused cell hybrids between influenza virus-primed mouse spleen cells and mouse myeloma cells can be maintained indefinitely in culture and continue to produce large amounts of anti-influenza antibody.
GB7826758A 1977-06-15 1978-06-13 Method of producing antibodies in vitro Withdrawn GB2000186A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80685777A 1977-06-15 1977-06-15

Publications (1)

Publication Number Publication Date
GB2000186A true GB2000186A (en) 1979-01-04

Family

ID=25194989

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7826758A Withdrawn GB2000186A (en) 1977-06-15 1978-06-13 Method of producing antibodies in vitro

Country Status (19)

Country Link
JP (2) JPS592276B2 (en)
AU (1) AU525724B2 (en)
BE (1) BE868099A (en)
CA (1) CA1103157A (en)
CH (1) CH640735A5 (en)
DE (1) DE2826075A1 (en)
DK (1) DK267378A (en)
ES (1) ES470729A1 (en)
FI (1) FI64952C (en)
FR (1) FR2394607A1 (en)
GB (1) GB2000186A (en)
IL (1) IL54908A (en)
IT (1) IT1096742B (en)
LU (1) LU79812A1 (en)
NL (1) NL7806471A (en)
NO (1) NO782081L (en)
PL (1) PL207652A1 (en)
SE (1) SE7806729L (en)
ZA (1) ZA783261B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014519A2 (en) * 1979-01-09 1980-08-20 National Research Development Corporation Cell lines, process for preparing them and process for producing antibodies
EP0027657A2 (en) * 1979-10-22 1981-04-29 The Massachusetts General Hospital Process for producing antibodies to hepatitis virus and cell lines therefor
EP0038642A1 (en) * 1980-04-09 1981-10-28 National Research Development Corporation A monoclonal antibody against hepatitis B and its production, a hybridoma producing the monoclonal antibody and compositions containing it, the propagation of the hybridoma and the monoclonal antibody for use as an antiviral agent against hepatitus B and in isolating hepatitus b surface antigen from a sample
US4608337A (en) * 1980-11-07 1986-08-26 The Wistar Institute Human hybridomas and the production of human monoclonal antibodies by human hybridomas
US4883752A (en) * 1984-10-26 1989-11-28 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Method for preparing monoclonal antibody to Hbsag
US5204095A (en) * 1980-04-09 1993-04-20 National Research Development Corporation Monoclonal antibodies against hepatitis B virus

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0008092B1 (en) 1978-08-10 1982-07-28 Schering Aktiengesellschaft Process for obtaining murine immunglobulin-e antibodies, hybrid cell lines used in the process and the process for preparing them, application of the immunglobulin-e antibodies so obtained
NL185309C (en) * 1980-07-28 1990-03-01 Akzo Nv METHOD FOR DETERMINING ANTIGENS USING TWO OR MORE MONOCLONAL ANTIBODIES AND IMMUNE REAGENTS.
JPS5825439B2 (en) * 1980-12-30 1983-05-27 株式会社林原生物化学研究所 Method for producing human parathyroid hormone
JPS609795B2 (en) * 1980-12-11 1985-03-13 株式会社林原生物化学研究所 Method for producing human epidermal growth factor
WO1982003089A1 (en) * 1981-03-06 1982-09-16 Lennox Edwin Samuel Monoclonal antibody
AU567693B2 (en) * 1982-09-30 1987-12-03 University Of Rochester Human monoclonal antibodies against bacterial toxins
JPH03271235A (en) * 1983-04-08 1991-12-03 Kureha Chem Ind Co Ltd Anti-candida antibody-secretive hybridoma
JPS60104020A (en) * 1983-10-14 1985-06-08 メルク　エンド　カムパニー　インコーポレーテツド Hepatitis a-protein subunit antigen
US4707442A (en) * 1983-10-24 1987-11-17 Board Of Regents, The University Of Texas System Hybrid cell line producing monoclonal antibody cytolytic to Trichomonas vaginalis
US5053224A (en) * 1983-11-07 1991-10-01 Hilary Koprowski Induction of antibody response to solid tumors with anti-idiotype antibodies
US4731237A (en) * 1983-11-07 1988-03-15 The Wistar Institute Immune response to virus induced by anti-idiotype antibodies
NL8401221A (en) * 1984-04-16 1985-11-18 Innovi Nv ANALYTICAL APPLICATION OF PHAGOCYT CELL LINES.
JPS6140800A (en) * 1984-07-27 1986-02-27 バイオテクノロジー　アンド　エクスペリメンタル　リサーチ　インコーポレーテツド Roduction of monoclonal antibody using electric cell fusion
JPS6181782A (en) * 1984-09-28 1986-04-25 Teijin Ltd Mouse-human hybridoma producing antivirus human antibody, its production and use
DE3581400D1 (en) * 1984-09-28 1991-02-21 Teijin Ltd MOUSE / HUMAN HYBRIDOMA WITH GENERATION OF ANTIVIRAL HUMAN ANTIBODIES, THEIR PRODUCTION AND ANTIVIRAL HUMAN MONOCLONAL ANTIBODIES.
JPS6226300A (en) * 1984-10-10 1987-02-04 セントコ−・インコ−ポレ−テツド Cloning and developping of htlv-iii dna
GB8501473D0 (en) * 1985-01-21 1985-02-20 Pasteur Institut Cloned dna sequences
JP2518607B2 (en) * 1985-08-29 1996-07-24 雪印乳業株式会社 Monoclonal antibody against influenza A virus HA antigen and method for producing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3423505A (en) * 1964-10-31 1969-01-21 Univ Toronto Rabies vaccine and process for preparation thereof
US3585266A (en) * 1969-02-24 1971-06-15 Dow Chemical Co Live rabies virus vaccine and method for the production thereof

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0014519A2 (en) * 1979-01-09 1980-08-20 National Research Development Corporation Cell lines, process for preparing them and process for producing antibodies
EP0014519A3 (en) * 1979-01-09 1981-01-07 National Research Development Corporation Cell lines, process for preparing them and process for producing antibodies
EP0027657A2 (en) * 1979-10-22 1981-04-29 The Massachusetts General Hospital Process for producing antibodies to hepatitis virus and cell lines therefor
EP0027657A3 (en) * 1979-10-22 1981-10-28 The Massachusetts General Hospital Process for producing antibodies to hepatitis virus and cell lines therefor
EP0038642A1 (en) * 1980-04-09 1981-10-28 National Research Development Corporation A monoclonal antibody against hepatitis B and its production, a hybridoma producing the monoclonal antibody and compositions containing it, the propagation of the hybridoma and the monoclonal antibody for use as an antiviral agent against hepatitus B and in isolating hepatitus b surface antigen from a sample
EP0232921A2 (en) * 1980-04-09 1987-08-19 Btg International Limited Monoclonal antibodies against hepatitis B virus
EP0232921A3 (en) * 1980-04-09 1987-10-07 National Research Development Corporation Monoclonal antibodies against hepatitis b virus
US5204095A (en) * 1980-04-09 1993-04-20 National Research Development Corporation Monoclonal antibodies against hepatitis B virus
US4608337A (en) * 1980-11-07 1986-08-26 The Wistar Institute Human hybridomas and the production of human monoclonal antibodies by human hybridomas
US4883752A (en) * 1984-10-26 1989-11-28 Juridical Foundation The Chemo-Sero-Therapeutic Research Institute Method for preparing monoclonal antibody to Hbsag

Also Published As

Publication number Publication date
AU525724B2 (en) 1982-11-25
AU3708878A (en) 1979-12-20
ES470729A1 (en) 1979-01-16
JPS5417185A (en) 1979-02-08
DE2826075C2 (en) 1987-08-06
DE2826075A1 (en) 1979-02-15
ZA783261B (en) 1979-06-27
IL54908A (en) 1982-01-31
CA1103157A (en) 1981-06-16
SE7806729L (en) 1978-12-16
JPS58101688A (en) 1983-06-16
FR2394607B1 (en) 1983-12-30
FI781818A (en) 1978-12-16
DK267378A (en) 1978-12-16
FI64952C (en) 1984-02-10
NL7806471A (en) 1978-12-19
CH640735A5 (en) 1984-01-31
BE868099A (en) 1978-10-02
LU79812A1 (en) 1978-12-07
JPS592276B2 (en) 1984-01-18
FR2394607A1 (en) 1979-01-12
NO782081L (en) 1978-12-15
FI64952B (en) 1983-10-31
IT1096742B (en) 1985-08-26
IL54908A0 (en) 1978-08-31
PL207652A1 (en) 1979-06-04
IT7824577A0 (en) 1978-06-14

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Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)