GB190412091A - Improvements in the Manufacture and Production of Pyrimidine Derivatives. - Google Patents

Improvements in the Manufacture and Production of Pyrimidine Derivatives.

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Publication number
GB190412091A
GB190412091A GB190412091DA GB190412091A GB 190412091 A GB190412091 A GB 190412091A GB 190412091D A GB190412091D A GB 190412091DA GB 190412091 A GB190412091 A GB 190412091A
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United Kingdom
Prior art keywords
urea
imino
cyano
pyrimidine
thio
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Expired
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Henry Edward Newton
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Individual
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Individual
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Abstract

12,091. Newton, H. E., [Farbenfabriken vorm. F. Bayer & Co.]. May 27. Dioxy-imino-, diamino-oxy-, and thio-imino-oxyalkyl pyrimidines.-Relates to improvements in the process described in Specifications Nos. 18,246, 21,833, and 22,967, A.D. 1903, for the production of pyrimidine derivatives of the general formula :- in which X denotes 0, NH, or S, R an alkyl radicle, and R, a hydrogen atom or alkyl radicle. Alkylated cyano-acetic esters are condensed with urea or thio-urea, by means of alkaline amides or alkali metals, or with guanidine with or without these condensing-agents. The following examples are given :-(1) The ethyl ester of mono-propyl cyano-acetic acid is heated with urea and sodium amide, the mass is dissolved in water, and the 2 6-dioxy-4-imino-5-monopropyl pyrimidine is isolated by addition of dilute acetic acid, and subsequent recrystallization from water. (2) The ethyl ester of diethyl cyano-acetic acid is similarly treated, and the 2 : 6-dioxy-4-imino-5-diethyl-pyrimidine is obtained. (3) The ethyl ester of dimethyl cyano-acetic acid is heated with finelydivided sodium and thio-urea, and 2-thio-4-imino- 5-dimethyl-6-oxy-pyrimidine is obtained. (4) The ethyl ester of diethyl cyano-acetic acid is heated with an alcoholic solution of guanidine ; the 2 : 4- di-imino-5-diethyl-6-oxy-pyrimidine crystallizes out. Derivatives of these compounds may be obtained by using derivatives or salts of urea, thio-urea, or guanidine, such as methyl-urea, or other alkylated cyano-acetic esters.
GB190412091D 1904-05-27 1904-05-27 Improvements in the Manufacture and Production of Pyrimidine Derivatives. Expired GB190412091A (en)

Applications Claiming Priority (1)

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GB190412091T 1904-05-27

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GB190412091A true GB190412091A (en) 1905-03-16

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GB190412091D Expired GB190412091A (en) 1904-05-27 1904-05-27 Improvements in the Manufacture and Production of Pyrimidine Derivatives.

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GB (1) GB190412091A (en)

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