GB1571045A - Process for the dimerisation of acrylonitrile and phosphorus iii compounds for use therein - Google Patents
Process for the dimerisation of acrylonitrile and phosphorus iii compounds for use therein Download PDFInfo
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- GB1571045A GB1571045A GB827477A GB827477A GB1571045A GB 1571045 A GB1571045 A GB 1571045A GB 827477 A GB827477 A GB 827477A GB 827477 A GB827477 A GB 827477A GB 1571045 A GB1571045 A GB 1571045A
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- United Kingdom
- Prior art keywords
- isopropyl
- acrylonitrile
- phenyl
- phosphinite
- phosphorus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 title claims description 48
- 238000000034 method Methods 0.000 title claims description 38
- 150000001875 compounds Chemical class 0.000 title claims description 14
- 229910052698 phosphorus Inorganic materials 0.000 title description 6
- 239000011574 phosphorus Substances 0.000 title description 6
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 title description 3
- -1 phosphorus (III) compound Chemical class 0.000 claims description 41
- 239000002904 solvent Substances 0.000 claims description 26
- 238000006243 chemical reaction Methods 0.000 claims description 23
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 16
- 125000001424 substituent group Chemical group 0.000 claims description 15
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000000539 dimer Substances 0.000 claims description 11
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- 125000003118 aryl group Chemical group 0.000 claims description 7
- 239000003960 organic solvent Substances 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 7
- TUAIJWODRGHANO-UHFFFAOYSA-N (4-methoxyphenyl)phosphinous acid Chemical compound COC1=CC=C(PO)C=C1 TUAIJWODRGHANO-UHFFFAOYSA-N 0.000 claims description 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 6
- 239000011541 reaction mixture Substances 0.000 claims description 6
- 125000003545 alkoxy group Chemical group 0.000 claims description 5
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims description 5
- 125000003282 alkyl amino group Chemical group 0.000 claims description 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 4
- QNYBZPOXCXPPTA-UHFFFAOYSA-N (4-methoxyphenyl)-di(propan-2-yloxy)phosphane Chemical compound COC1=CC=C(P(OC(C)C)OC(C)C)C=C1 QNYBZPOXCXPPTA-UHFFFAOYSA-N 0.000 claims description 3
- SRWTVZKUVJMXRN-UHFFFAOYSA-N 4-di(propan-2-yloxy)phosphanyl-n,n-dimethylaniline Chemical compound CC(C)OP(OC(C)C)C1=CC=C(N(C)C)C=C1 SRWTVZKUVJMXRN-UHFFFAOYSA-N 0.000 claims description 3
- IJKMYZFMJYVESJ-UHFFFAOYSA-N CN(C)C=1C(=C(C=CC=1)POC(C)C)N(C)C Chemical compound CN(C)C=1C(=C(C=CC=1)POC(C)C)N(C)C IJKMYZFMJYVESJ-UHFFFAOYSA-N 0.000 claims description 3
- SOYUHFOZZWBBBK-UHFFFAOYSA-N di(propan-2-yloxy)-(4-propan-2-yloxyphenyl)phosphane Chemical compound CC(C)OP(OC(C)C)C1=CC=C(OC(C)C)C=C1 SOYUHFOZZWBBBK-UHFFFAOYSA-N 0.000 claims description 3
- XUSGUQVDHTWNNW-UHFFFAOYSA-N (4-methylphenyl)phosphinous acid Chemical compound CC1=CC=C(PO)C=C1 XUSGUQVDHTWNNW-UHFFFAOYSA-N 0.000 claims description 2
- HFZVGJJPVHGDPV-UHFFFAOYSA-N (4-propan-2-yloxyphenyl)phosphinous acid Chemical compound CC(C)OC1=CC=C(PO)C=C1 HFZVGJJPVHGDPV-UHFFFAOYSA-N 0.000 claims description 2
- ZQOHAQBXINVHHC-HNQUOIGGSA-N (e)-hex-2-enedinitrile Chemical compound N#CCC\C=C\C#N ZQOHAQBXINVHHC-HNQUOIGGSA-N 0.000 claims description 2
- DOOWFJFNVFZABJ-UHFFFAOYSA-N diethoxy-(4-methoxyphenyl)phosphane Chemical compound CCOP(OCC)C1=CC=C(OC)C=C1 DOOWFJFNVFZABJ-UHFFFAOYSA-N 0.000 claims description 2
- NKSSUPDYDFPQTA-UHFFFAOYSA-N diethoxy-(4-propan-2-yloxyphenyl)phosphane Chemical compound CCOP(OCC)C1=CC=C(OC(C)C)C=C1 NKSSUPDYDFPQTA-UHFFFAOYSA-N 0.000 claims 1
- MJRXASKQOUNNCP-UHFFFAOYSA-N n,n-diethyl-4-[phenyl(propan-2-yloxy)phosphanyl]aniline Chemical compound C1=CC(N(CC)CC)=CC=C1P(OC(C)C)C1=CC=CC=C1 MJRXASKQOUNNCP-UHFFFAOYSA-N 0.000 claims 1
- 239000003054 catalyst Substances 0.000 description 16
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 15
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 8
- 239000006184 cosolvent Substances 0.000 description 8
- 239000000047 product Substances 0.000 description 7
- CSDQQAQKBAQLLE-UHFFFAOYSA-N 4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine Chemical compound C1=CC(Cl)=CC=C1C1C(C=CS2)=C2CCN1 CSDQQAQKBAQLLE-UHFFFAOYSA-N 0.000 description 6
- 239000007862 dimeric product Substances 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 4
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 4
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical class P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 4
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
- 230000002411 adverse Effects 0.000 description 3
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 3
- 125000005538 phosphinite group Chemical group 0.000 description 3
- 239000000376 reactant Substances 0.000 description 3
- 238000010992 reflux Methods 0.000 description 3
- VQTUBCCKSQIDNK-UHFFFAOYSA-N Isobutene Chemical compound CC(C)=C VQTUBCCKSQIDNK-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 238000001030 gas--liquid chromatography Methods 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 125000001183 hydrocarbyl group Chemical group 0.000 description 2
- 239000000543 intermediate Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 150000003018 phosphorus compounds Chemical class 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- PNJIMDUKYAWETG-UHFFFAOYSA-N (4-methoxyphenyl)phosphonous acid Chemical compound COC1=CC=C(P(O)O)C=C1 PNJIMDUKYAWETG-UHFFFAOYSA-N 0.000 description 1
- QAFSISQLQQGVOU-UHFFFAOYSA-N C(CCC)O[P] Chemical class C(CCC)O[P] QAFSISQLQQGVOU-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
- 229910000799 K alloy Inorganic materials 0.000 description 1
- 238000003109 Karl Fischer titration Methods 0.000 description 1
- 229910000528 Na alloy Inorganic materials 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 125000004429 atom Chemical group 0.000 description 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000000000 cycloalkoxy group Chemical group 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 239000002274 desiccant Substances 0.000 description 1
- 125000001664 diethylamino group Chemical group [H]C([H])([H])C([H])([H])N(*)C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000004508 fractional distillation Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000002638 heterogeneous catalyst Substances 0.000 description 1
- ZQOHAQBXINVHHC-UHFFFAOYSA-N hex-2-enedinitrile Chemical class N#CCCC=CC#N ZQOHAQBXINVHHC-UHFFFAOYSA-N 0.000 description 1
- 229940097275 indigo Drugs 0.000 description 1
- COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- 125000001624 naphthyl group Chemical group 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 150000002825 nitriles Chemical class 0.000 description 1
- NWVVVBRKAWDGAB-UHFFFAOYSA-N p-methoxyphenol Chemical compound COC1=CC=C(O)C=C1 NWVVVBRKAWDGAB-UHFFFAOYSA-N 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 150000002989 phenols Chemical class 0.000 description 1
- RPGWZZNNEUHDAQ-UHFFFAOYSA-N phenylphosphine Chemical class PC1=CC=CC=C1 RPGWZZNNEUHDAQ-UHFFFAOYSA-N 0.000 description 1
- XRBCRPZXSCBRTK-UHFFFAOYSA-N phosphonous acid Chemical class OPO XRBCRPZXSCBRTK-UHFFFAOYSA-N 0.000 description 1
- 125000004437 phosphorous atom Chemical group 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 150000003333 secondary alcohols Chemical class 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 150000003509 tertiary alcohols Chemical class 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000005292 vacuum distillation Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
- B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
- B01J31/0255—Phosphorus containing compounds
- B01J31/0257—Phosphorus acids or phosphorus acid esters
- B01J31/0262—Phosphorus acids or phosphorus acid esters comprising phosphinous acid (-ester) groups (R2P(OR')) or the isomeric phosphine oxide groups (R3P=O), i.e. R= C, R'= C, H
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/46—Phosphinous acids [R2POH], [R2P(= O)H]: Thiophosphinous acids including[R2PSH]; [R2P(=S)H]; Aminophosphines [R2PNH2]; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/48—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof
- C07F9/4808—Phosphonous acids [RP(OH)2] including [RHP(=O)(OH)]; Thiophosphonous acids including [RP(SH)2], [RHP(=S)(SH)]; Derivatives thereof the acid moiety containing a substituent or structure which is considered as characteristic
- C07F9/4841—Aromatic acids or derivatives (P-C aromatic linkage)
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
(54) PROCESS FOR THE DIMERISATION OF ACRYLONITRILE
AND NOVEL PHOSPHORUS Ill COMPOUNDS FOR USE
THEREIN
(71) We, IMPERIAL CHEMICAL INDUSTRIES LIMITED, Imperial
Chemical House, Millbank, London SW1P 3JF, a Brirish Company, do hereby declare the invention, for which we pray that a patent may be granted to us, and the method by which it is to be performed, to be particularly described in and by the following statement: This invention relates to a dimerisation process and, especially, to a process for the dimerisation of acrylonitrile to linear C6 dinitriles.
In our co-pending British Patent Application Nos. 45324/75 (Serial No.
1,546,807) and 52888/75 we describe and claim a process for the dimerisation of acrylonitrile to predominantly straight-chain C6 dimers comprising contacting the acrylonitrile with an organic phosphorus (III) compound which has at least one hydrocarbyl and at least one alkoxy or cycloalkoxy group attached to the phosphorous atom or atoms, the acrylonitrile being dissolved in an organic solvent capable of donating protons and the acrylonitrile and solvent being substantially dry.
We have now found that when at least one of the hydrocarbyl groups is selected from certain substituted aromatic groups, the rate of dimer formation is considerably enhanced.
According to the present invention, a process for the dimerisation of acrylontrile to predominantly straight-chain C6 dimers comprises contacting the acrylonitrile with an organic phosphorus (III) compound, the acrylonitrile being dissolved in an organic solvent capable of donating protons but substantially unreactive with acrylonitrile and the phosphorus (iII) compound under the dimerisation conditions, the acrylonitrile and solvent being substantially dry, and the phosphorus (III) compound being one of the formula:
where Ar is an aromatic nucleus, e.g. phenyl or naphthyl, and where groups X, which may be the same or different, are electron donating substituents of the aromatic nucleus in the para or meta positions which give rise to a negative Hammett cr constant and R represents an alkyl or cycloalkyl group, with the proviso that group X is not methyl. Substituents X may be in the para or meta positions; but are preferably para. In the case of compounds of formula (ii) above, substituents X may be para in one Ar group but meta in the other.
It will be appreciated that the phosphorus (III) compounds defined above are either phosphinites or phosphonites.
A discussion on Hammett Cr constants and a table showing values for most common substituents is to be found in an article by Clark and Perrin in Quarterly
Reviews, Vol 18, 1964 pp 295-320.
Examples of suitable substituents X include alkoxy groups, e.g. methoxy, ethoxy, i-propoxy and t-butoxy; alkyl groups, e.g. ethyl and propyl; and alkyl amino groups, e.g. dimethylamino and diethylamino. The alkoxy, alkyl and alkylamino groups preferably contain from 1 to 8 carbon atoms. - It is essential that group X should be one which does not react adversely with the components of the reaction system.
Suitable groups R include alkyl groups such as methyl, ethyl, isopropyl, neo pentyl, 2-ethylhexyl; and cycloalkyl groups such as cyclohexyl. It is noted that bulky groups R, for example isopropyl, may give rise to increased catalyst lifetime.
The presence of an organic solvent is essential to our process, since in the absence of solvent rapid polymerisation of the acrylonitrile occurs. Suitable solvents are proton-donating solvents which are substantially unreactive in respect of addition to, or reaction with, the unsaturated linkage of the acrylonitrile or the products of acrylonitrile dimerisation. Furthermore, the solvent must not react with the phosphorus compounds or catalytic intermediates to form inactive phosphorus species at such a rate as to seriously impair the dimerisation reaction. For example, phenols have been found to be unsuitable in this respect. The organic solvent must be rigorously dried, so as not to adversely affect catalyst lifetime.
Preferably hydroxylic solvents, such as alcohols, are used, provided always that they do not react adversely with the phosphorus compound or any intermediates it may form with acrylonitrile. This may be readily established by experiment Tertiary and secondary alcohols are preferred, for example, t-butylalcohol, 2-butanol and isopropanol. Isopropanol is often advantageous with the catalysts of the present invention in that it tends to promote faster reaction and enhance selectivity to straightchain dimers. On the other hand, t-butanol may undergo exchange reactions with the ester groups of the phosphorus compounds to give butoxy phosphorus derivatives which evolve isobutene, thus leading to catalytically inactive phosphorus (V) species.
Thus for optimum results it is advisable to determine the best solvent or solvent combination for use with the particuIar phosphorus (III) compound used.
The concentration of proton-donating solvent is generally in the range 0.1 to 50% by volume, calculated on the total volume of the reactants, but the optimum concentration will qry with the precise nature of the solvent and the catalyst compound. The molar concentration of proton-donating solvent will generally be greater than the molar concentration of the phosphorus (III) compound.
In order to reduce the amount of hexamer and/or other oligomers or polymers (hereafter referred to collectively as polymeric by-products or merely polymers) which may be co-produced with the desired dimeric products, ir is often desirable to add a non-hydroxylic co-solvent to the reaction mixture used in our process.
It will be apparent that the co-solvent must be dried to a level which maintains the overall anhydrous state of the system.
Suitable non-hydroxylic organic solvents include hydrocarbons, for example, hexane, cyclohexane, toluene, and petroleum ethers; ethers, for example, tetrahydrofuran, diethyl ether and diisopropyl ether; nitriles, for example acetonitrile, propionitrile; and fiuorobenzenes. The hydrocarbon co-solvents are generally preferred.
An essential feature of the present invention is that the reaction must be conducted in the substantlal absence of water. Without prejudice to our invention, we believe that the water reacts with the catalyst in the presence of acrylonitrile and/or dimeric products to give non-catalytic addition compounds. Thus, the acrylonitrile, proton-donating solvent and co-solvent must be dried before use, otherwise the catalyst lifetime may be reduced to a commercially unacceptable level. In particular acrylonitrile, which commonly contains as much as 4000 ppm of water, even after distillation, must be rigorously dried. It is also noted that phenolic stabilisers, e.g.
hydroquinone and its monomethyl ether, p-methoxyphenol, which are present in acrylonitrile as supplied, should be removed, for example by treatment with activated alumina.
Any suitable drying technique may be used, provided that the final water level is sufficiently low. For example, acrylonitrile and hydroxylic solvents may be dried by being contacted with calcium hydride or a 3A or 4A molecular sieve. The above findings contrast strongly with the teaching of the prior art which makes no mention of removal of water and/or phenolic stabilisers, and in many instances advocates the addition of water and stabilisers, such as hydroquinone, to the reaction mixture. Calcium hydride is a particularly suitable drying agent, as it also reacts with phenolic stabilisers to form sparingly soluble phenates, thus effecting their removal.
Generally the concentration of acrylonitrile in the solvent or solvent mixture should range from 5 to 75% by volume. The concentration of acrylonitrile is kept as high as possible in order to optimise throughout and thus concentrations in the range 10 to 50% by volume are generally preferred.
The concentration of the phosphorus compound in the reactant mixture may be varied over a wide range, for example, from 0.005, commonly 0.01, to 5% by volume, calculated on the volume cf liquid reactants; but preferably the concentration is in the range 0.01 to 1% by volume. When present, the proportion of co-solvent in the reaction mixture may be varied over wide limits. In general the ratio of protondonating solvent to co-solvent is in the range 1/40 to 40/1; but ratios at the lower end of the range are generally preferred. However, the final choice of solvent/cosolvent ratio will depend on how it is desired to run the process and the catalyst compound used. For example, ratios in the range 1/5 to 1/20 may give rise to enhanced catalyst lifetime and increased selectivity to linear dimer, when compared with an equivalent reaction where the ratio is 1/1.
Changes in the ratio of proton-donating solvent/co-solvent are generally reflected by changes in the amount of polymers formed and changes in the reaction rate.
These changes in reaction parameters are often dependent upon the actual catalyst and solvent system chosen.
The ratio of linear to branched dimers is also dependent on the solvent/cosolvent ratio in some instances. It is sometimes found that, as the proportion of proton-donating solvent decreases, the proportion of linear dimer increases, and viceversa.
The reaction temperature is commonly in the range 0 to 180"C; but it may be preferred to keep the range temperature below 75"C to minimise undesirable side reactions. It is noted that the reaction will proceed below 0 C, maintaining selectivity, but at a reduced rate. In fact, in some cases improved selectivity may be obtained at lower temperatures.
The reaction may be carried out batchwise or continuously. In the latter case, it may be convenient to support the catalyst compound or to use a polymeric tervalent phosphorus compound to enable the reaction to be carried out in the liquid phase using a heterogeneous catalyst.
The dimeric products of our invention are predominantly linear C6 dinitriles, especially the 1,4-dicyanobutenes. Selectivities > 90 wt % (calculated on total dimeric product) may be readily obtained.
The desired products may be readily separated from the reaction mixture for example by fractional distillation or solvent extraction.
According to a further aspect of our invention, we provide the following novel compounds, which fall within the above general formulae and may be used with advantage in the process of our invention.
isopropyl bis puisopropoxyphenylphosphinite, isopropyl phenyi(p-n:tthoxy- phenyl ) phosphinite, isopropyl phenyl (p-isopropoxyphenyl ) phosphinite, isopropyl phenyl (p-dimethylaminophenyl) phosphinite, isopropyl phenyl (p-tertiarybutoxy- phenyl ) phosphinine, di-isopropyl p-isopropoxyphenylphosphonite, di-ethyl p-iso propoxyphenylpho sphonite and cyclohexyl bis p-methoxyphenylphosphonite.
The invention will be illustrated by the following Examples, in which all parts are by volume.
In all Examples, except where otherwise stated, the acrylonitrile was dried before use by means of calcium hydride. This was accomplished by adding powdered calcium hydride to the acrylonitrile overnight, then decanting the acrylonitrile on to fresh calcium hydride powder and refluxing for 150 minutes. The acrylonitrile was then distilled from the calcium hydride. Water levels were found to be in the range 3080 ppm after this procedure. The acrylonitrile was dried finally by storing over freshly activated 3A molecular sieve to give levels below 15 ppm. Water levels were determined by the Karl Fischer titration procedure.
Isopropanol was dried as described above for ACN. Toluene was dried by refluxing it with a sodium/potassium alloy in the presence of benzophenone until the indigo colour of the ketyl was developed. The toluene was then distilled off, under an atmosphere of nitrogen, on to freshly dried 3A molecular sieve.
Cyclohexane was dried by refluxing it in the presence of triethylaluminlum.
The cyclohexane was then distilled off, under an atmosphere of nitrogen, on to freshly dried 3A molecular sieve.
In each case the dried solvent had a water level of < 15 ppm by volume.
The phosphorus (III) compounds used in the Examples are either commercially available or were prepared using methods given in "Organo-Phosphoms Compounds"
Kosolapoff and Maier published by Wiley 1972, Vol 4, Chapters 10 and 11, especially as described on pages 470 and 471.
All analyses of dimeric products were made by gas-liquid chromatography.
In all Examples, "% conversion" indicates the % by weight of acrylonitrile (ACN) converted to total dimeric, oligomeric and polymeric products; the "% yield" of a product is the weight of that product calculated as a % of the weight of ACN converted; and the "selectivity" is the proportion of straight-chain or linear dimers, calculated on the total dinteric product.
Examples 1-12.
Toluene (10 parts), acrylonitrile (3 parts) isopropanol (1 part) and stated catalyst compound (0.1 part) were mixed rigorously in a glass reactor in the absence of air and moisture. The reactor vessel was then immersed in a thermostatted oilbath for three hours. The reacted was then terminated by addition of a little water and acrylonitrile and the contents of the vessel stirred for 30 minutes. Any solid polymeric products were removed by filtration and the solvents and unreacted acrylonitrile were removed by vacuum distillation at room temperature. The non-volatile
residue was analysed for dimeric products by gas-liquid chromatography (g.l.c.), the results being presented in Table 1, below. With the exception of experiment C2, in each case the phenyl substituent was in the para position.
It will be seen from the results that the use of substituted phenyl phosphorus (III) compounds gave rise to a marked increase in the rate of dimer formation, compared with the unsubstituted phenyl compounds.
TABLE 1
Ex. Temp % Yield % Solid Rel T No. Catalyst Compound C Selectivity DCB-1 polymers rate 1 (MeOC6H4)2 POPri 60 89 70 3 100 2 (MeOC6H4)2 POPri 20 91 71 4 80 3 (PriOC6H4)2 POPri 60 91 77 2 200 4 (PriOC6H4)2POPri 20 93 79 < 1 25 5 (Me2NC6H4)2 POPri 60 83 20 12 300 6 (Me2NC6H4)2POPri 20 85 30 8 250 7 Ph(MeOC6H4)POPr 60 93 85 < 1 30 8 Ph(MeOC6H4)POPri 20 97 60 1 10 9 Ph(PriOC6H4)POPri 60 92 83 < 1 30 10 Ph(PriOC6H4)POPri 20 95 70 < 1 8 11 Ph(Me2 NC6H4)POPri 60 90 70 3 200 12 Ph(Me2NC6H4)POPri 20 91 77 2 50 C2 (oMeOC6H4)2 POPri 60 59 47 3 20 C1 Ph2POPri 60 95 85 < 1 1 "Ph" = phenyl, "Me" = methyl and Pri = isopropyl.
C1 is a comparative test using an unsubstituted phenyl phosphorus (III) compound.
C2 is a comparative test using an orthosubstituted phenyl compound. Although the rate is enhanced relative to experiment C1, the selectivity is reduced to an unacceptable level.
*"Rel Rate" signifies the rate of acrylonitrile consumption to 25% conversion compared with that of C1 which is taken as unity.
Examples 13-21.
The procedure of Examples 1-14 was flowed using the phosphorus (III)
compounds stated below. The reaction temperature was 60 C in each case, with the
exception of Example 25 which was conducted at 20 C. The results are given in
Table 2 below. In each case the phenyl substituent was in the para position.
TABLE 2
Ex. % Yield % Solid No. Catalyst Compound Selectivity DCB-1 Polymers Conversion 13 Ph(ButOC6H4)POPri 93.0 77.8 0.1 33.5 14 MeOC6H4 P(OPri)2 92.7 82.4 1.9 53.4 15 MeOC6H4P(OEt)2 93.3 77.3 2.0 59.4 16 Me2NC6H4P(OPri)2 91.0 65.4 3.1 25.0 17 Me2NC6H4P(OEt)2 92.1 57.3 7.8 88.9 18 PriOC6H4P(OPri)2 91.8 68.4 5.8 30.2 19 PriOC6H4 P(OEt)2 92.9 82.0 2.2 49.4 20 (MeOC6H4)2POc.Hex 90.7 86.3 1.2 59.4 21 (MeOC6H4)2POc.Hex 91.6 81.2 4.2 28.5 C2 Ph2POPri 96.3 87.2 0;2 8.1 * Conversion of acrylonitrile after 3 hours reaction.
"Et" = = ethyl "But" = tertiary butyl "c.Hex" = cyclohexyl.
C2 is a comparative test using an unsubstituted phenyl phosphorus (III) compound.
Examples 22-25.
The general procedure of Examples 1-14 was repeated, but cyclohexane was
used instead of toluene and reduced weight of catalyst as shown. Reaction temperature
was 60 C in each case. The results are given in Table 3 below:
TABLE 3
Ex. Parts % Yield No. Catalyst Compound Catalyst Selectivity DCB-1 Conversion 22 (MeOC6H4)2 POPri 0.051 85.9 36.0 55.6 23 Ph(MeOC6H4)POPri 0.054 92.5 59.0 16.2 24 Ph(Me2 NC6 H4 )POPrl 0.065 78.4 26.2 47.0 25 Ph(PriOC6H4)POPri 0.039 91.4 70.3 12.7 The phenyl substituents were in the para position.
Examples 26-27.
Isopropyl phenyl (para di-ethy aminophenyl) phosphinite was treated by the procedure of Examples 15-25 with the following results given in Table 4.
TABLE 4
Ex. Temp ele Yield % Solid No. OC Selectivity DUCK1 polymer Conversion 26 20 91 74 5.0 41 27 60 88.9 65.3 4.4 89 WHAT WE CLAIM IS:
1. A process for the dimerisation of acrylonitrile to predominantly straight-chain
C6 dimers which comprises contacting the acrylonitrile with an organic phosphorus (III) compound, the acrylonitrile being dissolved in an organic solvent capable of donating protons but substantially anreactive with acrylonitrile and the phosphorus (III) compound under the dimerisation conditions, the acrylonitrile and solvent being substantially dry, and the phosphorus (III) compound being one of formula:
where Ar is an aromatic nucleus and where groups X, which may be the same or different, are electron donating substituents of the aromatic nucleus in the para or meta positions which give rise to a negative Hammett cr constant and R represents an alkyl or cycloalkyl group, with the proviso that group X is not methyl.
2. A process according to claim 1, in which the substituent X, or at least one of the substituents X, is in the para position.
3. A process according to claim 1 or claim 2 in which the Ar group is a phenyl group.
4. A process according to any one of claims 1 to 3, in which the substituent X is chosen from alkoxy groups or alkylamino groups.
5. A process according to any one of claims 1 to 3, in which the phosphorus (III) compound is one of formula (ii) and the substituents X are alkyl groups.
6. A process according to claim 4 in which the phosphorus (III) compound is chosen from:
isopropyl bis p-isopropoxyphenylphosphinite, isopropyl phenyl (p-methoxy- phenyl ) phosphinite, isopropyl phenyl (p-isopropoxyphenyl)phosphinite, isopropyl phenyl (p-dimethylaminophenyl)phosphinite, isopropyl phenyl (p-tertiarybutoxyphenyl)phosphinite, di-isopropyl p-isopropoxyphenylpho sphonite, di-ethyl p-iso propoxypbenylphosphonite, cyclohexyl bis p-methoxyphenylphosphinite, isopropyl bis p-methoxyphenylphosphinite, isopropyl bis dimethylaminophenylphosphinite, diisopropyl p-methoxyphenylphosphonite, di-ethyl p-methoxyphenylphosphonite, diisopropyl p-dimethylaminophenylphosphonite, di-ethyl p-dimethylaminoPhenylphos- phonite, isopropyl phenyl (p-diethylaminophenyl) phosphinite.
7. A process according to claim 5, in which the phosphorus (III) compound is isopropyl bis p-methylphenylphosphinite.
8. A process according to any one of claims 1 to 7 in which the water level of the reaction mixture is < 15 ppm by volume.
9. A process for the dimerisation of acrylonitrile according to claim 1 and substantially as described in any one of the Examples.
10. 1,4-dicyanobutene, whenever prepared by a process as claimed in any one of the preceding claims.
11. As new compounds:
isopropyl bis pcisopropoxyphenylphosphinite, isopropyl phenyl (p-methoxy- phenyl ) phosphinite, isopropyl phenyl (p-isopropoxyphenyl)phosphinite, isopropyl phenyl (p-dimethylaminophenyl) phosphinite, isopropyl phenyl (p-tertiarybutoxyphenyl)phosphinite, di-isopropyl p-isopropoxyphenylphosphonite, di-ethyl p-iso
**WARNING** end of DESC field may overlap start of CLMS **.
Claims (11)
- **WARNING** start of CLMS field may overlap end of DESC **.TABLE 4Ex. Temp ele Yield % Solid No. OC Selectivity DUCK1 polymer Conversion 26 20 91 74 5.0 41 27 60 88.9 65.3 4.4 89 WHAT WE CLAIM IS: 1. A process for the dimerisation of acrylonitrile to predominantly straight-chain C6 dimers which comprises contacting the acrylonitrile with an organic phosphorus (III) compound, the acrylonitrile being dissolved in an organic solvent capable of donating protons but substantially anreactive with acrylonitrile and the phosphorus (III) compound under the dimerisation conditions, the acrylonitrile and solvent being substantially dry, and the phosphorus (III) compound being one of formula:where Ar is an aromatic nucleus and where groups X, which may be the same or different, are electron donating substituents of the aromatic nucleus in the para or meta positions which give rise to a negative Hammett cr constant and R represents an alkyl or cycloalkyl group, with the proviso that group X is not methyl.
- 2. A process according to claim 1, in which the substituent X, or at least one of the substituents X, is in the para position.
- 3. A process according to claim 1 or claim 2 in which the Ar group is a phenyl group.
- 4. A process according to any one of claims 1 to 3, in which the substituent X is chosen from alkoxy groups or alkylamino groups.
- 5. A process according to any one of claims 1 to 3, in which the phosphorus (III) compound is one of formula (ii) and the substituents X are alkyl groups.
- 6. A process according to claim 4 in which the phosphorus (III) compound is chosen from: isopropyl bis p-isopropoxyphenylphosphinite, isopropyl phenyl (p-methoxy- phenyl ) phosphinite, isopropyl phenyl (p-isopropoxyphenyl)phosphinite, isopropyl phenyl (p-dimethylaminophenyl)phosphinite, isopropyl phenyl (p-tertiarybutoxyphenyl)phosphinite, di-isopropyl p-isopropoxyphenylpho sphonite, di-ethyl p-iso propoxypbenylphosphonite, cyclohexyl bis p-methoxyphenylphosphinite, isopropyl bis p-methoxyphenylphosphinite, isopropyl bis dimethylaminophenylphosphinite, diisopropyl p-methoxyphenylphosphonite, di-ethyl p-methoxyphenylphosphonite, diisopropyl p-dimethylaminophenylphosphonite, di-ethyl p-dimethylaminoPhenylphos- phonite, isopropyl phenyl (p-diethylaminophenyl) phosphinite.
- 7. A process according to claim 5, in which the phosphorus (III) compound is isopropyl bis p-methylphenylphosphinite.
- 8. A process according to any one of claims 1 to 7 in which the water level of the reaction mixture is < 15 ppm by volume.
- 9. A process for the dimerisation of acrylonitrile according to claim 1 and substantially as described in any one of the Examples.
- 10. 1,4-dicyanobutene, whenever prepared by a process as claimed in any one of the preceding claims.
- 11. As new compounds: isopropyl bis pcisopropoxyphenylphosphinite, isopropyl phenyl (p-methoxy- phenyl ) phosphinite, isopropyl phenyl (p-isopropoxyphenyl)phosphinite, isopropyl phenyl (p-dimethylaminophenyl) phosphinite, isopropyl phenyl (p-tertiarybutoxyphenyl)phosphinite, di-isopropyl p-isopropoxyphenylphosphonite, di-ethyl p-isopropoxyphenylphosphonite, cyclohexyl bis p-methoxyphenylphosphinite, isopropyl phenyl(p-diethylaminophenyl)phosphinite, isopropyl bis p-methoxyphenylphosphinite, isopropyl bis dimethylaminophenylphosphinite, di-isopropyl p-methoxyphenylphosphonite, di-isopropyl p-dimethylaminophenylphosphonite, di-ethyl p-dimethylamino phenyiphosphonite.
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