GB1538921A - Amide derivatives of dimeric alkaloids - Google Patents
Amide derivatives of dimeric alkaloidsInfo
- Publication number
- GB1538921A GB1538921A GB281/76A GB28176A GB1538921A GB 1538921 A GB1538921 A GB 1538921A GB 281/76 A GB281/76 A GB 281/76A GB 28176 A GB28176 A GB 28176A GB 1538921 A GB1538921 A GB 1538921A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amide derivatives
- compounds
- converted
- dimeric
- alkaloids
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001408 amides Chemical class 0.000 title abstract 3
- 229930013930 alkaloid Natural products 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 2
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 230000000840 anti-viral effect Effects 0.000 abstract 1
- 229940034982 antineoplastic agent Drugs 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 239000003443 antiviral agent Substances 0.000 abstract 1
- 150000001540 azides Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
- 150000003335 secondary amines Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- JXLYSJRDGCGARV-CFWMRBGOSA-N vinblastine Chemical class C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-CFWMRBGOSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53968175A | 1975-01-09 | 1975-01-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1538921A true GB1538921A (en) | 1979-01-24 |
Family
ID=24152219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB281/76A Expired GB1538921A (en) | 1975-01-09 | 1976-01-06 | Amide derivatives of dimeric alkaloids |
Country Status (13)
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2019396A (en) * | 1978-04-20 | 1979-10-31 | Lilly Co Eli | 4-desacetyl containinig them and their use as pharmaceuticals |
| USRE30561E (en) | 1976-12-06 | 1981-03-31 | Eli Lilly And Company | Vinca alkaloid intermediates |
| US4357334A (en) | 1980-03-20 | 1982-11-02 | Eli Lilly And Company | Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR69783B (enrdf_load_stackoverflow) * | 1976-09-08 | 1982-07-07 | Lilly Co Eli | |
| IL53813A (en) * | 1977-01-19 | 1982-07-30 | Lilly Co Eli | 4'-deoxyvincristine and related compounds,their preparation and antitumor pharmaceutical compositions containing them |
| US4191688A (en) | 1977-08-08 | 1980-03-04 | Eli Lilly And Company | Amides of leurosine, leuroformine, desacetylleurosine and desacetylleuroformine |
| US4195022A (en) | 1978-03-27 | 1980-03-25 | Eli Lilly And Company | 4-Desacetoxy-4α-hydroxyvinblastine and related compounds |
| US4199504A (en) * | 1978-05-15 | 1980-04-22 | Eli Lilly And Company | Bridged cathranthus alkaloid dimers |
| AR225153A1 (es) * | 1978-10-10 | 1982-02-26 | Lilly Co Eli | Un procedimiento para la preparacion de sulfato de vindesina |
| LU83822A1 (fr) * | 1981-12-08 | 1983-09-01 | Omnichem Sa | Derives n-(vinblastinoyl-23)d'acides amines,leur preparation et leur application therapeutique |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR204004A1 (es) * | 1973-04-02 | 1975-11-12 | Lilly Co Eli | Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina |
-
1975
- 1975-12-17 IL IL48685A patent/IL48685A/xx unknown
- 1975-12-18 CA CA242,012A patent/CA1067073A/en not_active Expired
- 1975-12-19 PH PH17891A patent/PH17563A/en unknown
- 1975-12-19 IE IE2775/75A patent/IE42385B1/en unknown
- 1975-12-22 DE DE19752558027 patent/DE2558027A1/de not_active Ceased
- 1975-12-29 CH CH1684075A patent/CH624962A5/de not_active IP Right Cessation
- 1975-12-31 NL NL7515253A patent/NL7515253A/xx not_active Application Discontinuation
-
1976
- 1976-01-06 GB GB281/76A patent/GB1538921A/en not_active Expired
- 1976-01-07 CS CS7699A patent/CS199615B2/cs unknown
- 1976-01-08 BE BE1007122A patent/BE837390A/xx not_active IP Right Cessation
- 1976-01-08 HU HU76EI664A patent/HU176226B/hu not_active IP Right Cessation
- 1976-01-09 JP JP51002380A patent/JPS5195100A/ja active Pending
- 1976-01-09 FR FR7600519A patent/FR2297043A1/fr active Granted
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE30561E (en) | 1976-12-06 | 1981-03-31 | Eli Lilly And Company | Vinca alkaloid intermediates |
| GB2019396A (en) * | 1978-04-20 | 1979-10-31 | Lilly Co Eli | 4-desacetyl containinig them and their use as pharmaceuticals |
| US4357334A (en) | 1980-03-20 | 1982-11-02 | Eli Lilly And Company | Use of VLB 3-(2-chloroethyl) carboxamide in treating neoplasms |
Also Published As
| Publication number | Publication date |
|---|---|
| CS199615B2 (en) | 1980-07-31 |
| JPS5195100A (enrdf_load_stackoverflow) | 1976-08-20 |
| CA1067073A (en) | 1979-11-27 |
| IL48685A (en) | 1980-03-31 |
| NL7515253A (nl) | 1976-07-13 |
| FR2297043A1 (fr) | 1976-08-06 |
| FR2297043B1 (enrdf_load_stackoverflow) | 1978-08-11 |
| BE837390A (fr) | 1976-07-08 |
| HU176226B (en) | 1981-01-28 |
| IE42385B1 (en) | 1980-07-30 |
| IE42385L (en) | 1976-07-09 |
| IL48685A0 (en) | 1976-02-29 |
| CH624962A5 (en) | 1981-08-31 |
| PH17563A (en) | 1984-10-01 |
| DE2558027A1 (de) | 1976-07-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1522869A (en) | Substituted 4- halomethyl 2- pyrrolidinones and the use thereof as herbicides | |
| ES8106888A1 (es) | Un procedimiento de obtencion de un compuesto heterociclico pentagonal,saturado,que contiene nitrogeno | |
| GB1538921A (en) | Amide derivatives of dimeric alkaloids | |
| SE7704783L (sv) | Medel for separationsendamal och forfarande for dess framstellning | |
| GB1544872A (en) | 4-hydroxyphenylalkanolamine derivatives and preparation thereof | |
| ES450536A1 (es) | Procedimiento para la obtencion de cromanonas-(4). | |
| ES468501A1 (es) | Un procedimiento para la preparacion de derivados de imida- zodiacepina. | |
| SE7604476L (sv) | Forfarande for framstellning av 1-(3,3,3-triarylpropyl)-4-fenyl-4-piperidinmetanolforeningar | |
| SE7612964L (sv) | Tienamycinderivat | |
| ES462229A1 (es) | Un procedimiento para preparar una indol dihiindolcarboxami-da dimerica. | |
| ES414956A1 (es) | Procedimiento para la preparacion de 4-(4-bifenilil)-buta- noles. | |
| GB1492352A (en) | Imidazoles | |
| ES449068A1 (es) | Procedimiento para preparar derivados de isoxazol. | |
| CH609692A5 (en) | Process for the preparation of new piperazinopyrimidines | |
| ES475596A1 (es) | Procedimiento para la preparacion de derivados de fenoxial- canolaminas | |
| SE8300432D0 (sv) | Reaktiva kanelsyraderivat for framstellning av biologiskt aktiva amider | |
| CH614940A5 (en) | Process for the preparation of new terpenoaromatic amidines | |
| GB1549754A (en) | Processes for preparing n-substituted amides of 2-oxo-1-pyrrolidine | |
| JPS5236617A (en) | Process for preparation of formamide derivatives | |
| CH609049A5 (en) | Process for the preparation of 2-aminoimidazoles | |
| JPS51136696A (en) | Process for preparing aikylamino-substituted pyrimidopyrimidine deriva tives | |
| GB1509034A (en) | Herbicides | |
| GB1097057A (en) | Imidazolinonesulphonamide derivatives | |
| ES459262A1 (es) | Un procedimiento para obtener compuestos de cefalosporina. | |
| JPS52100472A (en) | 11thiazolyll55 acylimidazolidinone compound |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |