GB1529721A - Process for the manufacture of adenosines - Google Patents

Process for the manufacture of adenosines

Info

Publication number
GB1529721A
GB1529721A GB3478675A GB3478675A GB1529721A GB 1529721 A GB1529721 A GB 1529721A GB 3478675 A GB3478675 A GB 3478675A GB 3478675 A GB3478675 A GB 3478675A GB 1529721 A GB1529721 A GB 1529721A
Authority
GB
United Kingdom
Prior art keywords
hydroxyl groups
sugar
compounds
adenosines
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3478675A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2441484A external-priority patent/DE2441484A1/en
Application filed by Schering AG filed Critical Schering AG
Publication of GB1529721A publication Critical patent/GB1529721A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

N<6>-substituted adenosines of the following formula <IMAGE> in which the substituents R1, R2 and R3 are defined in Claim 1, and Z is a sugar residue with a phosphoric acid residue bonded via one or two hydroxyl groups in the same molecule or via two hydroxyl groups in different molecules, are prepared. The compounds are obtained by reacting a corresponding 6-trialkylsilyloxypurine derivative, in which the free hydroxyl groups of the sugar and of the phosphoric ester have undergone intermediate silylation, with ammonia or with an appropriate primary or secondary amine. The resulting compounds can be used as agents with antiproliferative and cardiovascular activity.
GB3478675A 1974-08-28 1975-08-27 Process for the manufacture of adenosines Expired GB1529721A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2441484A DE2441484A1 (en) 1971-10-08 1974-08-28 PROCESS FOR THE PREPARATION OF N HIGH 6-SUBSTITUTED ADENOSINE NUCLEOTIDES

Publications (1)

Publication Number Publication Date
GB1529721A true GB1529721A (en) 1978-10-25

Family

ID=5924435

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3478675A Expired GB1529721A (en) 1974-08-28 1975-08-27 Process for the manufacture of adenosines

Country Status (6)

Country Link
JP (1) JPS5148699A (en)
BE (1) BE832855R (en)
CH (1) CH615199A5 (en)
FR (1) FR2320307A2 (en)
GB (1) GB1529721A (en)
NL (1) NL7510155A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4600707A (en) * 1985-01-25 1986-07-15 Warner-Lambert Company Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl, S,S-dioxide adenosine compounds
US4636493A (en) * 1985-01-25 1987-01-13 Warner-Lambert Company Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl, S,S-dioxide adenosine compounds

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54106056A (en) * 1978-02-08 1979-08-20 Nippon Kokan Kk <Nkk> Equipment for blank out for steel plate
JPS6140421Y2 (en) * 1981-01-21 1986-11-18

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4600707A (en) * 1985-01-25 1986-07-15 Warner-Lambert Company Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl, S,S-dioxide adenosine compounds
US4636493A (en) * 1985-01-25 1987-01-13 Warner-Lambert Company Benzothien-3-yl adenosine; benzothien-3-yl adenosine, S-oxide; and benzothien-3-yl, S,S-dioxide adenosine compounds

Also Published As

Publication number Publication date
NL7510155A (en) 1976-03-02
BE832855R (en) 1976-03-01
FR2320307A2 (en) 1977-03-04
JPS5148699A (en) 1976-04-26
FR2320307B2 (en) 1979-01-05
CH615199A5 (en) 1980-01-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee