GB1529097A - Potentiated human growth hormone and process for producing same - Google Patents

Potentiated human growth hormone and process for producing same

Info

Publication number
GB1529097A
GB1529097A GB36893/76A GB3689376A GB1529097A GB 1529097 A GB1529097 A GB 1529097A GB 36893/76 A GB36893/76 A GB 36893/76A GB 3689376 A GB3689376 A GB 3689376A GB 1529097 A GB1529097 A GB 1529097A
Authority
GB
United Kingdom
Prior art keywords
hgh
growth hormone
human growth
modified
dialysed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB36893/76A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Clinic and Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic and Research Foundation filed Critical Scripps Clinic and Research Foundation
Publication of GB1529097A publication Critical patent/GB1529097A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1529097 Modified hGH SCRIPPS CLINIC & RESEARCH FOUNDATION 6 Sept 1976 [8 Sept 1975] 36893/76 Heading C3H A method of producing modified human growth hormone (hGH) of increased biological potency comprises digesting hGH with a proteinase to remove amino acid residues 137 to at most 149 and to at least 147 inclusive, and recovering the modified hGH. Preferably the proteinase is of bacterial origin, e.g. subtilisin. In an example hGH is digested in a solution of sodium phosphate containing subtilism. The reaction is terminated by addition of diisopropylfluorphosphate and the solution is then dialysed. The dialysed digest is then fractionated on DEAE-cellulose and three hGH fractions result.
GB36893/76A 1975-09-08 1976-09-06 Potentiated human growth hormone and process for producing same Expired GB1529097A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61092575A 1975-09-08 1975-09-08

Publications (1)

Publication Number Publication Date
GB1529097A true GB1529097A (en) 1978-10-18

Family

ID=24446955

Family Applications (1)

Application Number Title Priority Date Filing Date
GB36893/76A Expired GB1529097A (en) 1975-09-08 1976-09-06 Potentiated human growth hormone and process for producing same

Country Status (4)

Country Link
DE (1) DE2640431A1 (en)
GB (1) GB1529097A (en)
IT (1) IT1066215B (en)
SE (1) SE7609861L (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079345A (en) * 1988-08-19 1992-01-07 Eli Lilly And Company Proteins having growth hormone anabolic properties with reduced effect on carbohydrate metabolism

Also Published As

Publication number Publication date
DE2640431A1 (en) 1977-03-17
SE7609861L (en) 1977-03-09
IT1066215B (en) 1985-03-04

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee