GB1526382A - Transpentenenitrile compounds having antidiarrheal activity - Google Patents
Transpentenenitrile compounds having antidiarrheal activityInfo
- Publication number
- GB1526382A GB1526382A GB7498/77A GB749877A GB1526382A GB 1526382 A GB1526382 A GB 1526382A GB 7498/77 A GB7498/77 A GB 7498/77A GB 749877 A GB749877 A GB 749877A GB 1526382 A GB1526382 A GB 1526382A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- transpentenenitrile
- antidiarrheal activity
- feb
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000001142 anti-diarrhea Effects 0.000 title abstract 2
- ISBHMJZRKAFTGE-ONEGZZNKSA-N (e)-pent-2-enenitrile Chemical class CC\C=C\C#N ISBHMJZRKAFTGE-ONEGZZNKSA-N 0.000 title 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 229940124537 antidiarrhoeal agent Drugs 0.000 abstract 1
- 235000010290 biphenyl Nutrition 0.000 abstract 1
- 239000004305 biphenyl Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/660,205 US4002618A (en) | 1976-02-23 | 1976-02-23 | 2,2-Diphenyl-5-(4-substituted-piperidino)-3-trans-pentenenitriles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1526382A true GB1526382A (en) | 1978-09-27 |
Family
ID=24648578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB7498/77A Expired GB1526382A (en) | 1976-02-23 | 1977-02-22 | Transpentenenitrile compounds having antidiarrheal activity |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4002618A (enExample) |
| JP (1) | JPS52125172A (enExample) |
| CA (1) | CA1095048A (enExample) |
| DE (1) | DE2707520A1 (enExample) |
| FR (1) | FR2342964A1 (enExample) |
| GB (1) | GB1526382A (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1332236C (en) * | 1985-10-11 | 1994-10-04 | Lourens Wals | ,--diaryl-4-aryl-4-hydroxy-1-piperidinebutanamide, n-oxides |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1129955A (en) * | 1966-03-03 | 1968-10-09 | Wyeth John & Brother Ltd | Unsaturated nitriles and esters and derivatives thereof |
| US3539579A (en) * | 1967-11-22 | 1970-11-10 | Janssen Pharm | 1 - (3 - cyano - 3,3 - diphenyl - propyl) - 4- phenyl - piperidine - 4 - carboxylic acid esters |
| GB1356117A (en) * | 1970-12-16 | 1974-06-12 | Searle & Co | 1-3-cyano-3,3-diphenylpropyl-4-phenylpiperidine-4-carboxylic acid derivatives |
| US3847926A (en) * | 1972-07-20 | 1974-11-12 | Searle & Co | Process for the production of diphenoxylate,its derivatives and its salts using an aqueous dmf solvent system |
| US3790581A (en) * | 1972-08-17 | 1974-02-05 | Searle & Co | N-(1-(3-cyano-3,3-bis(optionally substituted phenyl)propyl)-4-phenylpiperidine-4-carbonyloxy)succinimides |
-
1976
- 1976-02-23 US US05/660,205 patent/US4002618A/en not_active Expired - Lifetime
-
1977
- 1977-02-22 GB GB7498/77A patent/GB1526382A/en not_active Expired
- 1977-02-22 DE DE19772707520 patent/DE2707520A1/de not_active Withdrawn
- 1977-02-22 CA CA272,322A patent/CA1095048A/en not_active Expired
- 1977-02-23 JP JP1908577A patent/JPS52125172A/ja active Pending
- 1977-02-23 FR FR7705297A patent/FR2342964A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| CA1095048A (en) | 1981-02-03 |
| DE2707520A1 (de) | 1977-08-25 |
| US4002618A (en) | 1977-01-11 |
| FR2342964B1 (enExample) | 1978-11-17 |
| FR2342964A1 (fr) | 1977-09-30 |
| JPS52125172A (en) | 1977-10-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |