GB1526205A - Treatment of interferon-like material - Google Patents

Treatment of interferon-like material

Info

Publication number
GB1526205A
GB1526205A GB4813574A GB4813574A GB1526205A GB 1526205 A GB1526205 A GB 1526205A GB 4813574 A GB4813574 A GB 4813574A GB 4813574 A GB4813574 A GB 4813574A GB 1526205 A GB1526205 A GB 1526205A
Authority
GB
United Kingdom
Prior art keywords
interferon
sulphydryl groups
sulphydryl
agent
dialysis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4813574A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle and Co Ltd
GD Searle LLC
Original Assignee
GD Searle and Co Ltd
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle and Co Ltd, GD Searle LLC filed Critical GD Searle and Co Ltd
Priority to GB4813574A priority Critical patent/GB1526205A/en
Priority to JP50133553A priority patent/JPS5191320A/ja
Priority to FR7533991A priority patent/FR2290222A1/en
Priority to DE19752549768 priority patent/DE2549768A1/en
Priority to CA239,141A priority patent/CA1059029A/en
Priority to BE161679A priority patent/BE835355A/en
Publication of GB1526205A publication Critical patent/GB1526205A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

1526205 Stabilizing interferon G D SEARLE & CO Ltd 31 Oct 1975 [7 Nov 1974] 48135/74 Heading A5B Aqueous interferon preparations are stabilized against inactivation due to mechanical stress, (i.e. the biological inactivation caused by conditions encountered during purification, concentration, packaging procedures, filtration and storage, probably due to formation of sulphydryl group interlinkage or dissulphide interchange reactions to form inter- or intra-molecular disulphide bridges), by treatment with an agent which will selectively retain interferon sulphydryl groups in the reduced state but not reduce essential disulphide linkages, or an agent which will selectively block interferon sulphydryl groups. Suitable agents retaining sulphydryl groups in a reduced state are reduced glutathione, thiodiglycol, thioethanolamine, C 1-7 thioalkanoic acids, monothioglycerol, dithiotreietol, thioctic acid, cysteine, N-acetylcysteine and N- acetyl homocysteine. These materials may subsequently be removed from the interferon solution by dialysis against a buffer solution. Agents which block the interferon sulphydryl groups are pchloromercuribenzoate and phydroxymercuribenzoate, which cannot be removed by dialysis. The interferon preparation may be produced from a fibroblast cell culture.
GB4813574A 1974-11-07 1974-11-07 Treatment of interferon-like material Expired GB1526205A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB4813574A GB1526205A (en) 1974-11-07 1974-11-07 Treatment of interferon-like material
JP50133553A JPS5191320A (en) 1974-11-07 1975-11-06
FR7533991A FR2290222A1 (en) 1974-11-07 1975-11-06 PROCESS FOR STABILIZING THE INTERFERON AGAINST MECHANICAL CONSTRAINTS
DE19752549768 DE2549768A1 (en) 1974-11-07 1975-11-06 PROCEDURE FOR STABILIZING INTERFERON AGAINST MECHANICAL STRESS
CA239,141A CA1059029A (en) 1974-11-07 1975-11-06 Stabilization of interferon against mechanical stress
BE161679A BE835355A (en) 1974-11-07 1975-11-07 PROCESS FOR STABILIZING THE INTERFERON AGAINST MECHANICAL CONSTRAINTS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4813574A GB1526205A (en) 1974-11-07 1974-11-07 Treatment of interferon-like material

Publications (1)

Publication Number Publication Date
GB1526205A true GB1526205A (en) 1978-09-27

Family

ID=10447515

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4813574A Expired GB1526205A (en) 1974-11-07 1974-11-07 Treatment of interferon-like material

Country Status (6)

Country Link
JP (1) JPS5191320A (en)
BE (1) BE835355A (en)
CA (1) CA1059029A (en)
DE (1) DE2549768A1 (en)
FR (1) FR2290222A1 (en)
GB (1) GB1526205A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027573A2 (en) * 1979-10-19 1981-04-29 The Medical College Of Wisconsin, Inc. Method of stabilizing interferon and composition containing it
US5508031A (en) * 1986-11-21 1996-04-16 Cetus Oncology Corporation Method for treating biological damage using a free-radial scavenger and interleukin-2
AU680858B2 (en) * 1992-12-22 1997-08-14 Wellcome Foundation Limited, The Therapeutic combination containing interferon

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4100150A (en) 1975-11-04 1978-07-11 G. D. Searle & Co. Stabilization of interferon against mechanical stress using thioctic acid
JPS5892622A (en) * 1981-11-28 1983-06-02 Sunstar Inc Pharmaceutical preparation containing stably compounded interferon
AU1234383A (en) * 1982-03-17 1983-09-22 Inter-Yeda Ltd. Interferon stabilised with polyvinyl-pyrrolidone
US4432895A (en) * 1982-11-24 1984-02-21 Hoffmann-La Roche Inc. Monomeric interferons
JP2577744B2 (en) * 1986-07-18 1997-02-05 中外製薬株式会社 Stable granulocyte colony-stimulating factor containing preparation
CA1321349C (en) * 1986-11-21 1993-08-17 Robert Zimmerman Therapeutic combination of free-radical scavenger or metabolic inhibitor and biologically active protein

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0027573A2 (en) * 1979-10-19 1981-04-29 The Medical College Of Wisconsin, Inc. Method of stabilizing interferon and composition containing it
EP0027573A3 (en) * 1979-10-19 1981-10-14 The Medical College Of Wisconsin, Inc. Method of stabilizing interferon and composition containing it
US5508031A (en) * 1986-11-21 1996-04-16 Cetus Oncology Corporation Method for treating biological damage using a free-radial scavenger and interleukin-2
US5667776A (en) * 1986-11-21 1997-09-16 Chiron Corporation Treatment for biological damage using tumor necrosis factor and a free-radical scavenger
US5702697A (en) * 1986-11-21 1997-12-30 Chiron Corporation Treatment for biological damage using a colony stimulating factor and a biological modifier
AU680858B2 (en) * 1992-12-22 1997-08-14 Wellcome Foundation Limited, The Therapeutic combination containing interferon
US5830455A (en) * 1992-12-22 1998-11-03 Glaxo Wellcome Inc. Method of treatment using a therapeutic combination of α interferon and free radical scavengers

Also Published As

Publication number Publication date
JPS5191320A (en) 1976-08-10
FR2290222A1 (en) 1976-06-04
DE2549768A1 (en) 1976-05-20
BE835355A (en) 1976-03-01
CA1059029A (en) 1979-07-24
FR2290222B1 (en) 1981-12-04

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee