GB1523038A - Decapeptide - Google Patents
DecapeptideInfo
- Publication number
- GB1523038A GB1523038A GB24961/76A GB2496176A GB1523038A GB 1523038 A GB1523038 A GB 1523038A GB 24961/76 A GB24961/76 A GB 24961/76A GB 2496176 A GB2496176 A GB 2496176A GB 1523038 A GB1523038 A GB 1523038A
- Authority
- GB
- United Kingdom
- Prior art keywords
- asp
- thr
- tyr
- phe
- obzl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/595—Gastrins; Cholecystokinins [CCK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
1523038 Decapeptide SOC FARMACEUTICI KALIANA SpA 13 June 1977 [16 June 1976] 24961/76 Heading C3H [Also in Division C2] H - Pyroglu - Gln - Asp - Tyr - Thr - Gly- Trp - Nle - Asp - Phe - NH2 wherein the hydroxyl of Tyr is optionally protected by sulphate radical; and/or the hydroxyl of Thr is optionally protected by an acetyl radical; and the non-toxic, pharmaceutically-acceptable salts thereof with an inorganic base or organic base. Decapeptides of the invention prepared are: H - Pyroglu - Gln - Asp - Tyr(R1) - Thr(R2). Gly - Trp - Nle - Asp - Phe - NH2 wherein R1 is H and R2 is Ac, R1 is SO3H and R<2> is Ac, R1 is SO3H and R2 is H. Peptide intermediates isolated are: PENTAPEPTIDES: Z - Pyroglu - Gln- Asp(OBzl) - Tyr - Thr(Ac) - NHNHZ ; H - Pyroglu - Gln - Asp Tyr - Thr(Ac) - NHNH2; Boc and H-Gly-Trp-Nle-Asp-Phe-NH2. TETRAPEPTIDES: Boc and H - Gln- Asp(OBzl) - Tyr - Thr(Ac) - NHNHZ; Z - Trp- Nle - Asp(OBzl) - Phe - NH2; H - Trp - Nle- Asp-Phe-NH2. TRIPEPTIDES: Boc and H Asp(OBzl)- Tyr - Thr(Ac) - NHNHZ; Boc and H - Nle- Asp(OBzl)-Phe-NH2. DIPEPTIDES: Boc and H - Tyr - Thr(Ac) - NHNHZ; Boc and H-Asp(OBzl)-Phe-NH2.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB24961/76A GB1523038A (en) | 1976-06-16 | 1976-06-16 | Decapeptide |
FR7718157A FR2367738A1 (en) | 1976-06-16 | 1977-06-14 | NEW CERULETIDE-TYPE DECAPEPTIDE RESISTANT TO OXIDATION AND USED IN THERAPEUTICS |
JP7041477A JPS52153957A (en) | 1976-06-16 | 1977-06-14 | Novel decapeptide* its preparation and pharmacologically effective agent conatining same |
DE2727048A DE2727048C2 (en) | 1976-06-16 | 1977-06-15 | 8-norleucyl-ceruletide |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB24961/76A GB1523038A (en) | 1976-06-16 | 1976-06-16 | Decapeptide |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1523038A true GB1523038A (en) | 1978-08-31 |
Family
ID=10220014
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB24961/76A Expired GB1523038A (en) | 1976-06-16 | 1976-06-16 | Decapeptide |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS52153957A (en) |
DE (1) | DE2727048C2 (en) |
FR (1) | FR2367738A1 (en) |
GB (1) | GB1523038A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3061586D1 (en) * | 1979-04-30 | 1983-02-17 | Max Planck Gesellschaft | Pancreozymin-cholezystokinin active peptides, process for their preparation and pharmaceutical compositions containing them |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3472832A (en) | 1966-08-09 | 1969-10-14 | Farmaceutici Italia | Peptides related to caerulein |
-
1976
- 1976-06-16 GB GB24961/76A patent/GB1523038A/en not_active Expired
-
1977
- 1977-06-14 JP JP7041477A patent/JPS52153957A/en active Granted
- 1977-06-14 FR FR7718157A patent/FR2367738A1/en active Granted
- 1977-06-15 DE DE2727048A patent/DE2727048C2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE2727048A1 (en) | 1977-12-29 |
DE2727048C2 (en) | 1984-06-07 |
JPS52153957A (en) | 1977-12-21 |
FR2367738A1 (en) | 1978-05-12 |
JPS6115080B2 (en) | 1986-04-22 |
FR2367738B1 (en) | 1980-02-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19940613 |