FR2367738A1 - NEW CERULETIDE-TYPE DECAPEPTIDE RESISTANT TO OXIDATION AND USED IN THERAPEUTICS - Google Patents

NEW CERULETIDE-TYPE DECAPEPTIDE RESISTANT TO OXIDATION AND USED IN THERAPEUTICS

Info

Publication number
FR2367738A1
FR2367738A1 FR7718157A FR7718157A FR2367738A1 FR 2367738 A1 FR2367738 A1 FR 2367738A1 FR 7718157 A FR7718157 A FR 7718157A FR 7718157 A FR7718157 A FR 7718157A FR 2367738 A1 FR2367738 A1 FR 2367738A1
Authority
FR
France
Prior art keywords
decapeptide
new
radical
ceruletide
therapeutics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7718157A
Other languages
French (fr)
Other versions
FR2367738B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmaceutici Italia SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmaceutici Italia SpA filed Critical Farmaceutici Italia SpA
Publication of FR2367738A1 publication Critical patent/FR2367738A1/en
Application granted granted Critical
Publication of FR2367738B1 publication Critical patent/FR2367738B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/595—Gastrins; Cholecystokinins [CCK]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention a pour objet un décapeptide nouveau. Il est constitué par un pyroglutamyl-glutaminyl-aspartyl-tyrosyl-thréonyl-glycyl-tryptophyl-norleucyl-aspartyl-phénylalaninamide dont le groupe phénolique du radical tyrosyle est libre ou bloqué par un radical sulfurique et dont le groupe hydroxy du radical thréonyle est libre ou bloqué par un radical acétyle; l'invention couvre aussi les sels de ce composé avec une base organique ou minérale. Les composés de l'invention sont utiles pour le diagnostic des troubles cholécystiques et pancréatiques.The subject of the invention is a new decapeptide. It consists of a pyroglutamyl-glutaminyl-aspartyl-tyrosyl-threonyl-glycyl-tryptophyl-norleucyl-aspartyl-phenylalaninamide in which the phenolic group of the tyrosyl radical is free or blocked by a sulfuric radical and in which the hydroxy group of the threonyl radical is free or blocked by an acetyl radical; the invention also covers the salts of this compound with an organic or inorganic base. The compounds of the invention are useful for the diagnosis of cholecystic and pancreatic disorders.

FR7718157A 1976-06-16 1977-06-14 NEW CERULETIDE-TYPE DECAPEPTIDE RESISTANT TO OXIDATION AND USED IN THERAPEUTICS Granted FR2367738A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB24961/76A GB1523038A (en) 1976-06-16 1976-06-16 Decapeptide

Publications (2)

Publication Number Publication Date
FR2367738A1 true FR2367738A1 (en) 1978-05-12
FR2367738B1 FR2367738B1 (en) 1980-02-08

Family

ID=10220014

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7718157A Granted FR2367738A1 (en) 1976-06-16 1977-06-14 NEW CERULETIDE-TYPE DECAPEPTIDE RESISTANT TO OXIDATION AND USED IN THERAPEUTICS

Country Status (4)

Country Link
JP (1) JPS52153957A (en)
DE (1) DE2727048C2 (en)
FR (1) FR2367738A1 (en)
GB (1) GB1523038A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0049500B1 (en) * 1979-04-30 1984-02-22 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Tyrosine derivatives, process for their production and their use in the synthesis of peptides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3472832A (en) * 1966-08-09 1969-10-14 Farmaceutici Italia Peptides related to caerulein

Also Published As

Publication number Publication date
DE2727048A1 (en) 1977-12-29
FR2367738B1 (en) 1980-02-08
JPS6115080B2 (en) 1986-04-22
GB1523038A (en) 1978-08-31
DE2727048C2 (en) 1984-06-07
JPS52153957A (en) 1977-12-21

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Legal Events

Date Code Title Description
TP Transmission of property
ST Notification of lapse