GB1516382A - Process for the preparation of 11beta-hydroxy-18-alkyl-estrane compounds - Google Patents

Process for the preparation of 11beta-hydroxy-18-alkyl-estrane compounds

Info

Publication number
GB1516382A
GB1516382A GB27317/75A GB2731775A GB1516382A GB 1516382 A GB1516382 A GB 1516382A GB 27317/75 A GB27317/75 A GB 27317/75A GB 2731775 A GB2731775 A GB 2731775A GB 1516382 A GB1516382 A GB 1516382A
Authority
GB
United Kingdom
Prior art keywords
alkyl
hydroxy
resulting
group
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB27317/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo NV
Original Assignee
Akzo NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NLAANVRAGE7409512,A external-priority patent/NL188581C/en
Application filed by Akzo NV filed Critical Akzo NV
Publication of GB1516382A publication Critical patent/GB1516382A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Compounds of the formula I in which R is alkyl with 1-4 C atoms R1 is H2, H(OR3), O or ketalised O R2 is O, O, H(OR4) or ( alpha -alkyl) ( beta OR4), where the alkyl group contains 1-4 C atoms, and R3 and R4 are each a hydrogen atom or a protective group, and a double bond is present in position 4,5 or 5,6, are obtained by reacting a corresponding 11 beta -hydroxy oestrane compound with an acyl hypoiodite, reacting the resulting 11 beta -hydroxy-13-iodomethylgonane group, after protection of the hydroxyl groups, with an alkali metal C1-C4-alkyl compound or with dimethylformamide in the presence of an alkali metal C1-C4-alkyl compound, and treating the resulting compound with a proton donor, after which the resulting 18-carbaldehyde group is reduced or reacted with a Wittig reagent, and subsequently the resulting 18-alkenyl group is reduced and the hydroxyl groups are removed. <IMAGE>
GB27317/75A 1974-07-15 1975-06-27 Process for the preparation of 11beta-hydroxy-18-alkyl-estrane compounds Expired GB1516382A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NLAANVRAGE7409512,A NL188581C (en) 1974-07-15 1974-07-15 PROCESS FOR PREPARING 11BETA-HYDROXY-18-ALKYLESTRAIN COMPOUNDS.

Publications (1)

Publication Number Publication Date
GB1516382A true GB1516382A (en) 1978-07-05

Family

ID=19821753

Family Applications (1)

Application Number Title Priority Date Filing Date
GB27317/75A Expired GB1516382A (en) 1974-07-15 1975-06-27 Process for the preparation of 11beta-hydroxy-18-alkyl-estrane compounds

Country Status (12)

Country Link
JP (1) JPS6044317B2 (en)
CA (1) CA1062247A (en)
CH (1) CH626630A5 (en)
DD (1) DD120017A5 (en)
DE (1) DE2531145C2 (en)
DK (1) DK136532B (en)
FR (1) FR2283149A1 (en)
GB (1) GB1516382A (en)
HU (1) HU171987B (en)
NZ (1) NZ178105A (en)
SE (1) SE408797B (en)
SU (1) SU576957A3 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61191861U (en) * 1985-05-24 1986-11-29
JPS621857U (en) * 1985-06-21 1987-01-08

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2138285A1 (en) * 1971-05-21 1973-01-05 Choay Sa Crystalline, solid 3-beta-acetoxy-18-iodo pregnanes - as stable inter for pharmacologically active steroids

Also Published As

Publication number Publication date
FR2283149B1 (en) 1979-05-11
CA1062247A (en) 1979-09-11
SE7508027L (en) 1976-01-16
NZ178105A (en) 1978-04-03
DK136532C (en) 1978-03-28
FR2283149A1 (en) 1976-03-26
DD120017A5 (en) 1976-05-20
JPS6044317B2 (en) 1985-10-02
CH626630A5 (en) 1981-11-30
DE2531145A1 (en) 1976-02-05
HU171987B (en) 1978-05-28
SU576957A3 (en) 1977-10-15
JPS5134143A (en) 1976-03-23
DE2531145C2 (en) 1984-06-20
DK136532B (en) 1977-10-24
DK319875A (en) 1976-01-16
SE408797B (en) 1979-07-09

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Legal Events

Date Code Title Description
PS Patent sealed
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19940627