GB1502089A - Process for the production of derivatives of alpha-phenyl-propionic acid - Google Patents
Process for the production of derivatives of alpha-phenyl-propionic acidInfo
- Publication number
- GB1502089A GB1502089A GB8433/76A GB843376A GB1502089A GB 1502089 A GB1502089 A GB 1502089A GB 8433/76 A GB8433/76 A GB 8433/76A GB 843376 A GB843376 A GB 843376A GB 1502089 A GB1502089 A GB 1502089A
- Authority
- GB
- United Kingdom
- Prior art keywords
- arsonium
- derivatives
- alkyl
- production
- coor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1502089 Production of derivatives of α-phenylpropionic acid SIGURTA FARMACEUTICI SpA 3 March 1976 [8 July 1975] 08433/76 Heading C2C The invention relates to a method of preparing an α-phenylpropionic acid derivative of formula in which A is a group selected from -COOH, -CN and -COOR 1 , R 1 being an alkyl group having from 1 to 3 carbon atoms, comprising methylating a compound having the Formula II in which Y is -CN or -COOR 1 , R 1 being an alkyl group having from 1 to 3 carbon atoms, with a methylating agent in the presence of a catalyst selected from tetra-alkyl-phosphonium, -arsonium and -ammonium salts, tetraarylphosphonium and -arsonium salts and mixed alkyl-aryl-phosphonium and -arsonium salts, and if desired hydrolysing the product obtained. The following intermediates are prepared in the examples: 3-benzoylphenylacetonitrile by the reaction of 3-bromomethyl-benzophenone with NaCN, α-m-benzoylphenylacetic acid butyl and methyl esters by treating 3-bromomethyl benzophenone with n-butanol and carbon monoxide in the presence of tri-n-butylamine and cis Pd[P(C 6 H 5 ) 3 ] 2 Cl 2 . The butyl ester thus produced is transesterified to produce a methyl ester of the above compound.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT68770/75A IT1036466B (en) | 1975-07-08 | 1975-07-08 | PROCESS FOR THE PREPARATION OF DERIVATIVES OF ALPHA PHENYLPROPIONIC ACID |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1502089A true GB1502089A (en) | 1978-02-22 |
Family
ID=11310531
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB8433/76A Expired GB1502089A (en) | 1975-07-08 | 1976-03-03 | Process for the production of derivatives of alpha-phenyl-propionic acid |
Country Status (12)
Country | Link |
---|---|
JP (1) | JPS5210245A (en) |
BE (1) | BE837624A (en) |
CA (1) | CA1072113A (en) |
DE (1) | DE2626020A1 (en) |
DK (1) | DK306676A (en) |
ES (1) | ES449613A1 (en) |
FI (1) | FI761971A (en) |
FR (1) | FR2317274A1 (en) |
GB (1) | GB1502089A (en) |
IT (1) | IT1036466B (en) |
NO (1) | NO762399L (en) |
SE (1) | SE7607753L (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
YU39370B (en) * | 1976-10-18 | 1984-10-31 | Lek Tovarna Farmacevtskih | Process for the preparation of 2-(3-benzoylphenyl)-propionic acid |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1007643A (en) * | 1972-10-24 | 1977-03-29 | Janssen Pharmaceutica Naamloze Vennootschap | Aroyl-substituted phenylacetic acid derivatives |
IT1049426B (en) * | 1975-05-16 | 1981-01-20 | Italfarmaco Spa | 2-Aryl-propionic acid prepn. - by extractive methylation of aryl-acetonitrile and alkaline hydrolysis in aqueous - alkanol |
-
1975
- 1975-07-08 IT IT68770/75A patent/IT1036466B/en active
-
1976
- 1976-01-16 BE BE2054763A patent/BE837624A/en unknown
- 1976-03-03 GB GB8433/76A patent/GB1502089A/en not_active Expired
- 1976-04-26 JP JP51046673A patent/JPS5210245A/en active Pending
- 1976-05-03 CA CA251,644A patent/CA1072113A/en not_active Expired
- 1976-06-10 DE DE19762626020 patent/DE2626020A1/en not_active Withdrawn
- 1976-06-24 FR FR7619840A patent/FR2317274A1/en active Granted
- 1976-07-06 FI FI761971A patent/FI761971A/fi not_active Application Discontinuation
- 1976-07-07 SE SE7607753A patent/SE7607753L/en unknown
- 1976-07-07 ES ES449613A patent/ES449613A1/en not_active Expired
- 1976-07-07 DK DK306676A patent/DK306676A/en unknown
- 1976-07-08 NO NO762399A patent/NO762399L/no unknown
Also Published As
Publication number | Publication date |
---|---|
SE7607753L (en) | 1977-01-09 |
NO762399L (en) | 1977-01-11 |
DE2626020A1 (en) | 1977-01-27 |
CA1072113A (en) | 1980-02-19 |
FR2317274B1 (en) | 1981-09-18 |
FI761971A (en) | 1977-01-09 |
DK306676A (en) | 1977-01-09 |
ES449613A1 (en) | 1977-07-01 |
FR2317274A1 (en) | 1977-02-04 |
IT1036466B (en) | 1979-10-30 |
BE837624A (en) | 1976-05-14 |
JPS5210245A (en) | 1977-01-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PCNP | Patent ceased through non-payment of renewal fee |