GB1500518A - Isolation of utero-evacuant substances from plant extract - Google Patents

Isolation of utero-evacuant substances from plant extract

Info

Publication number
GB1500518A
GB1500518A GB14406/75A GB1440675A GB1500518A GB 1500518 A GB1500518 A GB 1500518A GB 14406/75 A GB14406/75 A GB 14406/75A GB 1440675 A GB1440675 A GB 1440675A GB 1500518 A GB1500518 A GB 1500518A
Authority
GB
United Kingdom
Prior art keywords
chloroform
benzene
extracted
water
organic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB14406/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ortho Pharmaceutical Corp
Original Assignee
Ortho Pharmaceutical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/489,688 external-priority patent/US3996132A/en
Application filed by Ortho Pharmaceutical Corp filed Critical Ortho Pharmaceutical Corp
Publication of GB1500518A publication Critical patent/GB1500518A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D313/00Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
    • C07D313/02Seven-membered rings
    • C07D313/04Seven-membered rings not condensed with other rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1500518 Substituted oxepane derivatives ORTHO PHARMACEUTICAL CORP 8 April 1975 [11 April 1974 18 July 1974 6 Feb 1975] 14406/75 Heading C2C Compounds of formula are extracted from a zoapatle plant, e.g. Montanoa tomentosa or Montanoa floribunda, with water at 25-100‹ C. the aqueous extract being treated with a water-immiscible organic liquid to isolate the extracted compound. Alternatively the compound may be extracted with an organic liquid, the extract being treated with water. Suitable organic liquids for both processes include ethyl acetate, hexane, chloroform and benzene. The product may be purified by taking it up in an organic solvent, e.g. chloroform, carbon tetrachloride, methylene chloride, diethyl ether or benzene, treating the resultant solution with a mild base, e.g. sodium bicarbonate, carbonate or acetate, applying the organic phase to a chromatography column of, for example, polyvinyl acetate, silicic acid or silica gel and washing it off the column with a mixed solvent, e.g. benzene/ethyl acetate, hexane/dioxan or chloroform/isopropanol. Two or more chromatographic purification steps may be carried out.
GB14406/75A 1974-04-11 1975-04-08 Isolation of utero-evacuant substances from plant extract Expired GB1500518A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46025874A 1974-04-11 1974-04-11
US05/489,688 US3996132A (en) 1974-07-18 1974-07-18 Purification of utero-evacuant extracts from plant substances
US54741575A 1975-02-06 1975-02-06

Publications (1)

Publication Number Publication Date
GB1500518A true GB1500518A (en) 1978-02-08

Family

ID=27412801

Family Applications (1)

Application Number Title Priority Date Filing Date
GB14406/75A Expired GB1500518A (en) 1974-04-11 1975-04-08 Isolation of utero-evacuant substances from plant extract

Country Status (8)

Country Link
AT (1) AT348668B (en)
AU (1) AU497132B2 (en)
GB (1) GB1500518A (en)
HU (1) HU170481B (en)
IL (1) IL47067A (en)
NZ (1) NZ177020A (en)
RO (1) RO68831A (en)
YU (1) YU37433B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1819351A1 (en) * 2004-06-09 2007-08-22 Purimed Co., Ltd. Poncirus trifoliata extract for preventing and treating ischemic heart diseases and phar^ maceutical composition and health food containing the same

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1819351A1 (en) * 2004-06-09 2007-08-22 Purimed Co., Ltd. Poncirus trifoliata extract for preventing and treating ischemic heart diseases and phar^ maceutical composition and health food containing the same
EP1819351A4 (en) * 2004-06-09 2007-08-29 Purimed Co Ltd Poncirus trifoliata extract for preventing and treating ischemic heart diseases and phar^ maceutical composition and health food containing the same

Also Published As

Publication number Publication date
ATA272275A (en) 1978-07-15
YU90475A (en) 1983-04-27
AU7980575A (en) 1976-10-07
YU37433B (en) 1984-08-31
RO68831A (en) 1982-05-10
IL47067A0 (en) 1975-06-25
HU170481B (en) 1977-06-28
AT348668B (en) 1979-02-26
AU497132B2 (en) 1978-11-30
IL47067A (en) 1978-12-17
NZ177020A (en) 1978-09-20

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee