GB1498348A - Naphthyridine derivatives - Google Patents
Naphthyridine derivativesInfo
- Publication number
- GB1498348A GB1498348A GB38671/76A GB3867176A GB1498348A GB 1498348 A GB1498348 A GB 1498348A GB 38671/76 A GB38671/76 A GB 38671/76A GB 3867176 A GB3867176 A GB 3867176A GB 1498348 A GB1498348 A GB 1498348A
- Authority
- GB
- United Kingdom
- Prior art keywords
- reacting
- prepared
- compound
- trifluoromethyl
- anhydride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/54—Preparation of carboxylic acid anhydrides
- C07C51/56—Preparation of carboxylic acid anhydrides from organic acids, their salts, their esters or their halides, e.g. by carboxylation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1498348 Naphthyridine derivatives RHONEPOULENC SA 17 Sept 1976 [22 Sept 1975] 38671/76 Addition to 1417935 Heading C2C Novel compounds II in which Y is H, halogen, C 1-4 alkyl, C 1-4 alkoxy, CN or NO 2 and R is H, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 hydroxyalkyl or phenyl, and acid addition salts thereof, are prepared by (a) reacting a compound IV with a 1-R-2-chlorocarbonyl-piperazine, or (b) reacting a mixed carbonate of a compound IV with a 1-R-piperazine. Compounds IV are prepared by partial reduction of corresponding imides which are themselves prepared by reacting a trifluoromethyl-substituted anhydride with a 2-amino- 7-Y-naphthyridine. 4 - Trifluoromethyl - phthalic anhydride is prepared by converting 2-amino-4-trifluoromethylbenzoic acid to the methyl ester, diazotizing the ester and reacting the diazo compound with KCN to form methyl 2-cyano-4-trifluoromethylbenzoate, hydrolysing this to form 4-trifluoromethyl-phthalic acid and cyclizing this to form the desired anhydride. Pharmaceutical compositions useful as tranquillizers and anticonvulsants comprise a compound II or a non-toxic acid addition salt thereof, together with a pharmaceutical carrier. The compositions may be in a form suitable for oral, parenteral, rectal or topical administration.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7528951A FR2324305A2 (en) | 1975-09-22 | 1975-09-22 | NEW DERIVATIVES OF ISOINDOLINE, THEIR PREPARATION AND THE COMPOSITIONS CONTAINING THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1498348A true GB1498348A (en) | 1978-01-18 |
Family
ID=9160275
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB38671/76A Expired GB1498348A (en) | 1975-09-22 | 1976-09-17 | Naphthyridine derivatives |
Country Status (26)
| Country | Link |
|---|---|
| JP (2) | JPS5239700A (en) |
| AR (1) | AR209515A1 (en) |
| AT (1) | AT349024B (en) |
| AU (1) | AU502308B2 (en) |
| BE (1) | BE846409R (en) |
| CH (2) | CH617696A5 (en) |
| CS (1) | CS196323B2 (en) |
| DD (1) | DD126905A6 (en) |
| DE (1) | DE2642598A1 (en) |
| DK (1) | DK142365B (en) |
| ES (1) | ES451741A2 (en) |
| FI (1) | FI59595C (en) |
| FR (1) | FR2324305A2 (en) |
| GB (1) | GB1498348A (en) |
| HU (1) | HU176005B (en) |
| IE (1) | IE43551B1 (en) |
| LU (1) | LU75838A1 (en) |
| MX (1) | MX3641E (en) |
| NL (1) | NL7610201A (en) |
| NO (1) | NO145098C (en) |
| PH (1) | PH12289A (en) |
| PL (2) | PL110655B1 (en) |
| SE (1) | SE423391B (en) |
| SU (1) | SU671724A3 (en) |
| YU (1) | YU230476A (en) |
| ZA (1) | ZA765589B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1282532C (en) * | 1986-08-22 | 1991-04-02 | Myron Timothy Maxson | Organosiloxane inhibitors for hydrosilation reactions and polyorganosiloxane compositions containing same |
| US6739238B2 (en) | 2000-11-20 | 2004-05-25 | Nissan Motor Co., Ltd. | Sliding structure for a reciprocating internal combustion engine and a reciprocating internal combustion engine using the sliding structure |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| OA04700A (en) * | 1973-05-15 | 1980-07-31 | Rhone Poulenc Sa | New derivatives of naphthyridine and their preparation process. |
-
1975
- 1975-09-22 FR FR7528951A patent/FR2324305A2/en active Granted
-
1976
- 1976-08-24 PH PH18826A patent/PH12289A/en unknown
- 1976-09-14 NL NL7610201A patent/NL7610201A/en not_active Application Discontinuation
- 1976-09-17 JP JP51110948A patent/JPS5239700A/en active Pending
- 1976-09-17 AU AU17893/76A patent/AU502308B2/en not_active Expired
- 1976-09-17 SU SU762403396A patent/SU671724A3/en active
- 1976-09-17 GB GB38671/76A patent/GB1498348A/en not_active Expired
- 1976-09-17 IE IE2064/76A patent/IE43551B1/en unknown
- 1976-09-17 ZA ZA765589A patent/ZA765589B/en unknown
- 1976-09-20 PL PL1976209687A patent/PL110655B1/en unknown
- 1976-09-20 MX MX764932U patent/MX3641E/en unknown
- 1976-09-20 AR AR264772A patent/AR209515A1/en active
- 1976-09-20 PL PL1976192537A patent/PL111060B1/en unknown
- 1976-09-20 YU YU02304/76A patent/YU230476A/en unknown
- 1976-09-21 HU HU76RO900A patent/HU176005B/en unknown
- 1976-09-21 BE BE170795A patent/BE846409R/en not_active IP Right Cessation
- 1976-09-21 LU LU75838A patent/LU75838A1/xx unknown
- 1976-09-21 CS CS766117A patent/CS196323B2/en unknown
- 1976-09-21 DD DD194904A patent/DD126905A6/xx unknown
- 1976-09-21 CH CH1196276A patent/CH617696A5/en not_active IP Right Cessation
- 1976-09-21 SE SE7610477-7A patent/SE423391B/en not_active IP Right Cessation
- 1976-09-21 NO NO763225A patent/NO145098C/en unknown
- 1976-09-21 DK DK425076AA patent/DK142365B/en not_active IP Right Cessation
- 1976-09-22 DE DE19762642598 patent/DE2642598A1/en not_active Ceased
- 1976-09-22 ES ES451741A patent/ES451741A2/en not_active Expired
- 1976-09-22 AT AT702476A patent/AT349024B/en not_active IP Right Cessation
- 1976-09-22 FI FI762699A patent/FI59595C/en not_active IP Right Cessation
-
1979
- 1979-09-04 CH CH796279A patent/CH617935A5/en not_active IP Right Cessation
-
1984
- 1984-10-09 JP JP59210605A patent/JPS6038392B2/en not_active Expired
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |