GB1495488A - Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids - Google Patents
Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acidsInfo
- Publication number
- GB1495488A GB1495488A GB2609676A GB2609676A GB1495488A GB 1495488 A GB1495488 A GB 1495488A GB 2609676 A GB2609676 A GB 2609676A GB 2609676 A GB2609676 A GB 2609676A GB 1495488 A GB1495488 A GB 1495488A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzoxazolyl
- optically active
- propionitrile
- phenyl
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KIUPORFCHKEHRJ-UHFFFAOYSA-N 2-(2-phenyl-1,3-benzoxazol-5-yl)propanoic acid Chemical class N=1C2=CC(C(C(O)=O)C)=CC=C2OC=1C1=CC=CC=C1 KIUPORFCHKEHRJ-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- YOCRMABISPGUSN-UHFFFAOYSA-N 2-(3-amino-4-hydroxyphenyl)propanenitrile Chemical compound N#CC(C)C1=CC=C(O)C(N)=C1 YOCRMABISPGUSN-UHFFFAOYSA-N 0.000 abstract 1
- YLOVYLOYLHRGAG-UHFFFAOYSA-N 2-(4-hydroxy-3-nitrophenyl)propanenitrile Chemical compound N#CC(C)C1=CC=C(O)C([N+]([O-])=O)=C1 YLOVYLOYLHRGAG-UHFFFAOYSA-N 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000002560 nitrile group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/56—Benzoxazoles; Hydrogenated benzoxazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D263/57—Aryl or substituted aryl radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2609676A GB1495488A (en) | 1976-06-23 | 1976-06-23 | Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids |
IE125977A IE45148B1 (en) | 1976-06-23 | 1977-06-20 | Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids |
LU77593A LU77593A1 (enrdf_load_stackoverflow) | 1976-06-23 | 1977-06-22 | |
DK276377A DK145418C (da) | 1976-06-23 | 1977-06-22 | Fremgangsmaade til fremstilling af et optisk aktivt derivat afen 2-(2-p-halogenphenyl-5-benzoxazolyl)-propionsyre |
IT2494677A IT1080779B (it) | 1976-06-23 | 1977-06-22 | Derivati dell'acido benzoxazolil-propionico otticamente attivi,processo per la loro preparazione e composizioni terapeutiche che li contengono |
NL7706959A NL189352C (nl) | 1976-06-23 | 1977-06-23 | Werkwijze voor het bereiden van optisch actieve benzoxazolylpropionzuurderivaten, alsmede van preparaten met deze verbindingen als actieve stof. |
CH773477A CH605865A5 (enrdf_load_stackoverflow) | 1976-06-23 | 1977-06-23 | |
BE178724A BE856044A (fr) | 1976-06-23 | 1977-06-23 | Derives optiquement actifs d'acide benzoxazolylpropionique, leur procede de preparation et leur utilisation |
JP7392477A JPS5331661A (en) | 1976-06-23 | 1977-06-23 | Optical active compound* its preparation and medical composition containing same as active ingredient |
DE19772728323 DE2728323A1 (de) | 1976-06-23 | 1977-06-23 | Optisch aktive derivate von benzoxazolylpropionsaeure, verfahren zu ihrer herstellung und arzneimittel |
FR7719236A FR2355839A1 (fr) | 1976-06-23 | 1977-06-23 | Derives optiquement actifs d'acide benzoxazolyl-propionique, procede pour leur preparation et compositions therapeutiques les contenant |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2609676A GB1495488A (en) | 1976-06-23 | 1976-06-23 | Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1495488A true GB1495488A (en) | 1977-12-21 |
Family
ID=10238311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2609676A Expired GB1495488A (en) | 1976-06-23 | 1976-06-23 | Optically active 2-(2-phenyl-5-benzoxazolyl)propionic acids |
Country Status (11)
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2432512A1 (fr) * | 1978-08-04 | 1980-02-29 | Ravizza Spa | Procede pour la preparation de derives de l'acide benzoxazolyl-propionique |
EP0169302A1 (en) * | 1984-07-23 | 1986-01-29 | RAVIZZA S.p.A. | Process for the resolution of (+) 2-/2'-(p-fluorophenyl)-5'-benzoxazolyl/-propionic acid |
EP0324402A1 (en) * | 1988-01-13 | 1989-07-19 | EURORESEARCH S.r.L. | Water-soluble salts of (+)2-(4-fluorophenyl)-alpha-methyl-5-benzoxazole acetic acid and their preparation process |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3888864A (en) | 1973-06-29 | 1975-06-10 | Hoffmann La Roche | Amino lower alkyl ether derivatives of opium alkaloids |
IT1157295B (it) * | 1982-07-19 | 1987-02-11 | Ravizza Spa | Processo perfezionato per la preparazione di derivati dell'acido benzoxazolil propionico |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL37633A (en) * | 1970-09-10 | 1975-08-31 | Merck & Co Inc | 2-(4-(2-benzoxazolyl)phenyl)alkanoic acid derivatives |
GB1435721A (en) * | 1972-05-18 | 1976-05-12 | Lilly Industries Ltd | Benzoxazole derivatives |
GB1590587A (en) * | 1977-06-28 | 1981-06-03 | Lilly Industries Ltd | Benoxaprofen |
-
1976
- 1976-06-23 GB GB2609676A patent/GB1495488A/en not_active Expired
-
1977
- 1977-06-20 IE IE125977A patent/IE45148B1/en not_active IP Right Cessation
- 1977-06-22 LU LU77593A patent/LU77593A1/xx unknown
- 1977-06-22 DK DK276377A patent/DK145418C/da not_active IP Right Cessation
- 1977-06-22 IT IT2494677A patent/IT1080779B/it active
- 1977-06-23 DE DE19772728323 patent/DE2728323A1/de active Granted
- 1977-06-23 FR FR7719236A patent/FR2355839A1/fr active Granted
- 1977-06-23 BE BE178724A patent/BE856044A/xx not_active IP Right Cessation
- 1977-06-23 CH CH773477A patent/CH605865A5/xx not_active IP Right Cessation
- 1977-06-23 NL NL7706959A patent/NL189352C/xx not_active IP Right Cessation
- 1977-06-23 JP JP7392477A patent/JPS5331661A/ja active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2432512A1 (fr) * | 1978-08-04 | 1980-02-29 | Ravizza Spa | Procede pour la preparation de derives de l'acide benzoxazolyl-propionique |
EP0169302A1 (en) * | 1984-07-23 | 1986-01-29 | RAVIZZA S.p.A. | Process for the resolution of (+) 2-/2'-(p-fluorophenyl)-5'-benzoxazolyl/-propionic acid |
US4698432A (en) * | 1984-07-23 | 1987-10-06 | Ravizza Spa | Process for the resolution of (±) 2-[2'-(p-fluorophenyl)-5'-benzoxazolyl]-propionic acid |
EP0324402A1 (en) * | 1988-01-13 | 1989-07-19 | EURORESEARCH S.r.L. | Water-soluble salts of (+)2-(4-fluorophenyl)-alpha-methyl-5-benzoxazole acetic acid and their preparation process |
Also Published As
Publication number | Publication date |
---|---|
IE45148L (en) | 1977-12-23 |
CH605865A5 (enrdf_load_stackoverflow) | 1978-10-13 |
NL189352B (nl) | 1992-10-16 |
NL189352C (nl) | 1993-03-16 |
JPS5331661A (en) | 1978-03-25 |
DE2728323C2 (enrdf_load_stackoverflow) | 1989-10-05 |
DK276377A (da) | 1977-12-24 |
IE45148B1 (en) | 1982-06-30 |
IT1080779B (it) | 1985-05-16 |
LU77593A1 (enrdf_load_stackoverflow) | 1977-09-29 |
DK145418B (da) | 1982-11-15 |
DK145418C (da) | 1983-04-11 |
NL7706959A (nl) | 1977-12-28 |
FR2355839B1 (enrdf_load_stackoverflow) | 1980-09-26 |
DE2728323A1 (de) | 1978-01-19 |
FR2355839A1 (fr) | 1978-01-20 |
BE856044A (fr) | 1977-10-17 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
PE20 | Patent expired after termination of 20 years |
Effective date: 19960622 |