GB1492361A - Optically active m-acyloxy-alpha(methylamino)methyl)-benzyl alcohols the pharmaceutically acceptable acid addition salts thereof and synthesis of same - Google Patents
Optically active m-acyloxy-alpha(methylamino)methyl)-benzyl alcohols the pharmaceutically acceptable acid addition salts thereof and synthesis of sameInfo
- Publication number
- GB1492361A GB1492361A GB5020/76A GB502076A GB1492361A GB 1492361 A GB1492361 A GB 1492361A GB 5020/76 A GB5020/76 A GB 5020/76A GB 502076 A GB502076 A GB 502076A GB 1492361 A GB1492361 A GB 1492361A
- Authority
- GB
- United Kingdom
- Prior art keywords
- optically active
- methyl
- acyloxy
- acid addition
- addition salts
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000001088 anti-asthma Effects 0.000 abstract 1
- 239000000924 antiasthmatic agent Substances 0.000 abstract 1
- 235000019445 benzyl alcohol Nutrition 0.000 abstract 1
- 150000003938 benzyl alcohols Chemical class 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 239000000850 decongestant Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 abstract 1
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 abstract 1
- 230000002911 mydriatic effect Effects 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 1
- 239000005526 vasoconstrictor agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/548,606 US3966749A (en) | 1975-02-10 | 1975-02-10 | Novel synthesis of optically active m-acyloxy-α-[(methylamino)methyl]benzyl alcohols, the pharmaceutically acceptable acid addition salts thereof and intermediate useful in the preparation thereof |
| US57807975A | 1975-05-16 | 1975-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1492361A true GB1492361A (en) | 1977-11-16 |
Family
ID=27068909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5020/76A Expired GB1492361A (en) | 1975-02-10 | 1976-02-09 | Optically active m-acyloxy-alpha(methylamino)methyl)-benzyl alcohols the pharmaceutically acceptable acid addition salts thereof and synthesis of same |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS51125339A (enrdf_load_stackoverflow) |
| AU (1) | AU1097976A (enrdf_load_stackoverflow) |
| DE (1) | DE2605111A1 (enrdf_load_stackoverflow) |
| FR (2) | FR2299860A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1492361A (enrdf_load_stackoverflow) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2933005C2 (de) * | 1979-08-14 | 1983-01-13 | Klinge Pharma GmbH, 8000 München | 1-(3-Acyloxyphenyl)-2-aminoethanole, deren Säureadditionssalze, diese enthaltende Arzneimittel, sowie Verfahren zu ihrer Herstellung |
| JPS5960914U (ja) * | 1982-10-19 | 1984-04-21 | 株式会社パイロット | ランドセル |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2341876A1 (de) * | 1973-08-18 | 1975-03-13 | Boehringer Sohn Ingelheim | Neue 1-(m-acyloxyphenyl)-1-hydroxy- 2-n-alkylamino-aethane, deren saeureadditionssalze, diese enthaltende arzneimittel, sowie verfahren zu ihrer herstellung |
-
1976
- 1976-02-09 GB GB5020/76A patent/GB1492361A/en not_active Expired
- 1976-02-10 FR FR7603644A patent/FR2299860A1/fr active Granted
- 1976-02-10 DE DE19762605111 patent/DE2605111A1/de active Pending
- 1976-02-10 JP JP51013859A patent/JPS51125339A/ja active Granted
- 1976-02-10 AU AU10979/76A patent/AU1097976A/en not_active Expired
- 1976-10-14 FR FR7630956A patent/FR2319634A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS56420B2 (enrdf_load_stackoverflow) | 1981-01-08 |
| JPS51125339A (en) | 1976-11-01 |
| FR2319634B1 (enrdf_load_stackoverflow) | 1979-03-23 |
| AU1097976A (en) | 1977-08-18 |
| DE2605111A1 (de) | 1976-08-19 |
| FR2299860B1 (enrdf_load_stackoverflow) | 1979-10-05 |
| FR2319634A1 (fr) | 1977-02-25 |
| FR2299860A1 (fr) | 1976-09-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |