GB1491261A - Cell-containing hollow fibres and use of same for metabolic processes - Google Patents

Cell-containing hollow fibres and use of same for metabolic processes

Info

Publication number
GB1491261A
GB1491261A GB20967/75A GB2096775A GB1491261A GB 1491261 A GB1491261 A GB 1491261A GB 20967/75 A GB20967/75 A GB 20967/75A GB 2096775 A GB2096775 A GB 2096775A GB 1491261 A GB1491261 A GB 1491261A
Authority
GB
United Kingdom
Prior art keywords
fibres
cells
metabolic
pregnenolone
transformation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB20967/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
COMMUNITY BLOOD COUNCIL
Original Assignee
COMMUNITY BLOOD COUNCIL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by COMMUNITY BLOOD COUNCIL filed Critical COMMUNITY BLOOD COUNCIL
Publication of GB1491261A publication Critical patent/GB1491261A/en
Expired legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/022—Artificial gland structures using bioreactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/08—Hollow fibre membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/10—Hollow fibers or tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/16—Hollow fibers

Abstract

1491261 Biochemical hormone production COMMUNITY BLOOD COUNCIL OF GREATER NEW YORK 16 May 1975 [17 May 1974] 20967/75 Heading C2U [Also in Divisions A5 C3 and C6] A method of biochemical transformation or synthesis involves, according to the preferred procedure, passing a metabolic precursor over or through hollow porous fibres into contact with mammalian cells (specified) disposed on the internal or external wall respectively, of the fibres, contacting this wall of the fibres with a physiologically compatible aqueous medium, and collecting the resulting metabolite or metabolic product. Example 3 describes the transformation of a metabolic precursor #-5- pregnenolone into the metabolic product corticosterone with 32% yield by passage of a cell culture medium containing the #-5-pregnenolone dissolved in ethanol through some 400 fibres having a coating of rat adrenal cortical cells disposed on the exterior walls. The fibres were made by depositing collagen solution on to preformed hollow filaments of polytetrafluoroethylene and cutting the coated filaments into 5 cm. lengths. They were porous to molecules of M.W. up to 1000. Similarly testosterone and progesterone are obtained from Eagle's medium supplemented with amino acids and fetal calf serum by contact with testicular hormone producing cells (interstitial cells of Leydig) and ovarian hormone producing cells (follicular and corpus luteal cells) respectively.
GB20967/75A 1974-05-17 1975-05-16 Cell-containing hollow fibres and use of same for metabolic processes Expired GB1491261A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47106574A 1974-05-17 1974-05-17

Publications (1)

Publication Number Publication Date
GB1491261A true GB1491261A (en) 1977-11-09

Family

ID=23870113

Family Applications (1)

Application Number Title Priority Date Filing Date
GB20967/75A Expired GB1491261A (en) 1974-05-17 1975-05-16 Cell-containing hollow fibres and use of same for metabolic processes

Country Status (6)

Country Link
BE (1) BE829222A (en)
BR (1) BR7503062A (en)
DE (1) DE2521793A1 (en)
FR (1) FR2270895B1 (en)
GB (1) GB1491261A (en)
ZA (1) ZA753084B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361484A (en) * 1979-06-11 1982-11-30 Gambro Ab Process for treating and/or removal of substances from liquid, especially whole blood
EP0082345A1 (en) * 1981-11-30 1983-06-29 Cordis Corporation Apparatus for therapeutic immunodepletion
GB2178447A (en) * 1985-06-18 1987-02-11 Yeda Res & Dev A matrix for cell cultivation in vitro
US4748121A (en) * 1984-11-30 1988-05-31 Ppg Industries, Inc. Porous glass fibers with immobilized biochemically active material
US4749653A (en) * 1985-10-21 1988-06-07 Owens-Corning Fiberglas Corporation Enzyme immobilization on non-porous glass fibers
US5162225A (en) * 1989-03-17 1992-11-10 The Dow Chemical Company Growth of cells in hollow fibers in an agitated vessel

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1085104A (en) * 1977-03-21 1980-09-09 Anthony M. Sun Artificial endocrine pancreas
NL7904388A (en) * 1978-06-15 1979-12-18 Mitsubishi Rayon Co METHOD AND DEVICE FOR TRANSFER OF GASES.
DE3129064A1 (en) * 1981-07-23 1983-02-10 Akzo Gmbh, 5600 Wuppertal Method and device for the oxygenation of blood
FR2531333B1 (en) * 1982-08-09 1986-04-04 Centre Nat Rech Scient BIO-ARTIFICIAL PANCREAS WITH ULTRAFILTRATION
JPS5980238A (en) * 1982-09-24 1984-05-09 ジ−ン−ベルナルド・ブチス Mount for composite artificial organ
DE4012079C2 (en) * 1990-04-14 1997-11-06 Jakob Dr Bodziony Implantable exchange and diffusion chamber
US20070082393A1 (en) * 2005-07-20 2007-04-12 Muhammad Lodhi Polymer coated nanofibrillar structures and methods for cell maintenance and differentiation
DE102010026322A1 (en) 2010-07-07 2011-10-27 Hohenstein Laboratories Gmbh & Co. Kg Medical surgical implant i.e. micro-surgical suturing thread, for repairing tissue damage from living tissue of patient during operation of tissue sections of wound, has hollow filament whose portion comprises filling element

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3734851A (en) * 1969-12-29 1973-05-22 K Matsumura Method and device for purifying blood
DE2054446A1 (en) * 1970-11-05 1972-05-10 Henning, George Ernest von, 6800 Mannheim Biological reaction chamber
DE2225862A1 (en) * 1972-05-27 1973-12-06 George Ernest Von Henning BIOLOGICAL REACTION CHAMBER

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4361484A (en) * 1979-06-11 1982-11-30 Gambro Ab Process for treating and/or removal of substances from liquid, especially whole blood
EP0082345A1 (en) * 1981-11-30 1983-06-29 Cordis Corporation Apparatus for therapeutic immunodepletion
US4748121A (en) * 1984-11-30 1988-05-31 Ppg Industries, Inc. Porous glass fibers with immobilized biochemically active material
GB2178447A (en) * 1985-06-18 1987-02-11 Yeda Res & Dev A matrix for cell cultivation in vitro
GB2178447B (en) * 1985-06-18 1989-12-28 Yeda Res & Dev A system for cell cultivation in vitro.
US4749653A (en) * 1985-10-21 1988-06-07 Owens-Corning Fiberglas Corporation Enzyme immobilization on non-porous glass fibers
US5162225A (en) * 1989-03-17 1992-11-10 The Dow Chemical Company Growth of cells in hollow fibers in an agitated vessel

Also Published As

Publication number Publication date
BR7503062A (en) 1976-04-13
BE829222A (en) 1975-09-15
DE2521793A1 (en) 1975-11-27
ZA753084B (en) 1976-04-28
FR2270895B1 (en) 1979-04-13
FR2270895A1 (en) 1975-12-12

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee