GB1478932A - 8-(3-chromanyl)-1-oxa-3,8-diazaspiro(4,5)decan-2-ones and thiones - Google Patents
8-(3-chromanyl)-1-oxa-3,8-diazaspiro(4,5)decan-2-ones and thionesInfo
- Publication number
- GB1478932A GB1478932A GB9356/75A GB935675A GB1478932A GB 1478932 A GB1478932 A GB 1478932A GB 9356/75 A GB9356/75 A GB 9356/75A GB 935675 A GB935675 A GB 935675A GB 1478932 A GB1478932 A GB 1478932A
- Authority
- GB
- United Kingdom
- Prior art keywords
- chromanyl
- reacting
- hydrogen
- prepared
- piperidinol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RZNRCXQEOLPLPC-UHFFFAOYSA-N 8-(3,4-dihydro-2H-chromen-3-yl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one Chemical class O1CC(CC2=CC=CC=C12)N1CCC2(CNC(O2)=O)CC1 RZNRCXQEOLPLPC-UHFFFAOYSA-N 0.000 title abstract 2
- 241001061127 Thione Species 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- OYCBZPBMXAIILZ-UHFFFAOYSA-N 1-(3,4-dihydro-2H-chromen-3-yl)piperidin-4-one Chemical compound O1CC(CC2=CC=CC=C12)N1CCC(CC1)=O OYCBZPBMXAIILZ-UHFFFAOYSA-N 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
- 239000005864 Sulphur Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- YSRWTMIEIJAFAZ-UHFFFAOYSA-N 1-(3,4-dihydro-2H-chromen-3-yl)-4-hydroxypiperidine-4-carbonitrile Chemical compound O1CC(CC2=CC=CC=C12)N1CCC(CC1)(O)C#N YSRWTMIEIJAFAZ-UHFFFAOYSA-N 0.000 abstract 1
- YWYLZOPZRDFEDH-UHFFFAOYSA-N 2-[1-(3,4-dihydro-2H-chromen-3-yl)-4-hydroxypiperidin-4-yl]acetohydrazide Chemical compound O1CC(CC2=CC=CC=C12)N1CCC(CC1)(O)CC(=O)NN YWYLZOPZRDFEDH-UHFFFAOYSA-N 0.000 abstract 1
- PWBDHTBBZHDLEX-UHFFFAOYSA-N 4-(aminomethyl)-1-(3,4-dihydro-2H-chromen-3-yl)piperidin-4-ol Chemical compound O1CC(CC2=CC=CC=C12)N1CCC(CC1)(O)CN PWBDHTBBZHDLEX-UHFFFAOYSA-N 0.000 abstract 1
- SHHLMGCHMMCOOS-UHFFFAOYSA-N 4h-chromen-3-one Chemical compound C1=CC=C2CC(=O)COC2=C1 SHHLMGCHMMCOOS-UHFFFAOYSA-N 0.000 abstract 1
- 238000006969 Curtius rearrangement reaction Methods 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000006680 Reformatsky reaction Methods 0.000 abstract 1
- ICWNTMAMVNXCIS-UHFFFAOYSA-N [1-(3,4-dihydro-2H-chromen-3-yl)-2-ethyl-4-hydroxypiperidin-4-yl] acetate Chemical compound C(C)(=O)OC1(CC(N(CC1)C1COC2=CC=CC=C2C1)CC)O ICWNTMAMVNXCIS-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Chemical group 0.000 abstract 1
- 230000002804 anti-anaphylactic effect Effects 0.000 abstract 1
- 230000003182 bronchodilatating effect Effects 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 abstract 1
- HDFRDWFLWVCOGP-UHFFFAOYSA-N carbonothioic O,S-acid Chemical class OC(S)=O HDFRDWFLWVCOGP-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000002081 enamines Chemical class 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- CTDQAGUNKPRERK-UHFFFAOYSA-N spirodecane Chemical compound C1CCCC21CCCCC2 CTDQAGUNKPRERK-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9356/75A GB1478932A (en) | 1975-03-06 | 1975-03-06 | 8-(3-chromanyl)-1-oxa-3,8-diazaspiro(4,5)decan-2-ones and thiones |
| FR7606067A FR2302741A1 (fr) | 1975-03-06 | 1976-03-04 | Derives du chromanne |
| BE164927A BE839275A (fr) | 1975-03-06 | 1976-03-05 | Derives du chromanne |
| JP51024036A JPS51113876A (en) | 1975-03-06 | 1976-03-05 | Chromanyl compounds preparation method and medical composite containing chromanyl compouds |
| DE19762609245 DE2609245A1 (de) | 1975-03-06 | 1976-03-05 | Chromanderivate, verfahren zur ihrer herstellung und sie enthaltende arzneimittel |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9356/75A GB1478932A (en) | 1975-03-06 | 1975-03-06 | 8-(3-chromanyl)-1-oxa-3,8-diazaspiro(4,5)decan-2-ones and thiones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1478932A true GB1478932A (en) | 1977-07-06 |
Family
ID=9870361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB9356/75A Expired GB1478932A (en) | 1975-03-06 | 1975-03-06 | 8-(3-chromanyl)-1-oxa-3,8-diazaspiro(4,5)decan-2-ones and thiones |
Country Status (5)
| Country | Link |
|---|---|
| JP (1) | JPS51113876A (enrdf_load_stackoverflow) |
| BE (1) | BE839275A (enrdf_load_stackoverflow) |
| DE (1) | DE2609245A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2302741A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1478932A (enrdf_load_stackoverflow) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2666583B1 (fr) * | 1990-09-06 | 1994-09-09 | Adir | Nouveaux derives du spiro [4.5] decane, leur procede de preparation et leurs compositions pharmaceutiques les renfermant. |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1377610A (en) * | 1970-12-19 | 1974-12-18 | Logeais Labor Jacques | 5-piperidine-4-spiro- oxazolidinones method for their preparation and applications thereof |
-
1975
- 1975-03-06 GB GB9356/75A patent/GB1478932A/en not_active Expired
-
1976
- 1976-03-04 FR FR7606067A patent/FR2302741A1/fr active Granted
- 1976-03-05 JP JP51024036A patent/JPS51113876A/ja active Granted
- 1976-03-05 BE BE164927A patent/BE839275A/xx unknown
- 1976-03-05 DE DE19762609245 patent/DE2609245A1/de not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| FR2302741B1 (enrdf_load_stackoverflow) | 1979-09-21 |
| FR2302741A1 (fr) | 1976-10-01 |
| JPS558495B2 (enrdf_load_stackoverflow) | 1980-03-04 |
| BE839275A (fr) | 1976-09-06 |
| DE2609245A1 (de) | 1976-09-16 |
| JPS51113876A (en) | 1976-10-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |