GB1471755A - Derivatives of digoxin and digotoxin - Google Patents
Derivatives of digoxin and digotoxinInfo
- Publication number
- GB1471755A GB1471755A GB2751074A GB2751074A GB1471755A GB 1471755 A GB1471755 A GB 1471755A GB 2751074 A GB2751074 A GB 2751074A GB 2751074 A GB2751074 A GB 2751074A GB 1471755 A GB1471755 A GB 1471755A
- Authority
- GB
- United Kingdom
- Prior art keywords
- digoxin
- chr
- yields
- reaction
- digitoxin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical class C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 title abstract 4
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical class C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 abstract 3
- 229960005156 digoxin Drugs 0.000 abstract 3
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 abstract 3
- WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229960000648 digitoxin Drugs 0.000 abstract 2
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 abstract 1
- 238000003776 cleavage reaction Methods 0.000 abstract 1
- 238000003127 radioimmunoassay Methods 0.000 abstract 1
- 230000007017 scission Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
- C07J19/005—Glycosides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2751074A GB1471755A (en) | 1974-06-20 | 1974-06-20 | Derivatives of digoxin and digotoxin |
| CA229,511A CA1070670A (en) | 1974-06-20 | 1975-06-17 | Labelled derivatives of digoxin and digitoxin |
| FR7518872A FR2275483A1 (fr) | 1974-06-20 | 1975-06-17 | Derives radio-actifs de la digoxine et de la digitoxine utilisables pour le titrage radiometrique de ces substances |
| JP50075012A JPS5851626B2 (ja) | 1974-06-20 | 1975-06-18 | ジゴキシンまたはジギトキシンに対する放射線免疫分析法 |
| DE2526984A DE2526984C3 (de) | 1974-06-20 | 1975-06-18 | Digoxin- und Digitoxinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung zur Bestimmung von Digoxin und Digitoxin |
| US05/588,165 US4029880A (en) | 1974-06-20 | 1975-06-19 | Labelled derivatives of steroids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2751074A GB1471755A (en) | 1974-06-20 | 1974-06-20 | Derivatives of digoxin and digotoxin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1471755A true GB1471755A (en) | 1977-04-27 |
Family
ID=10260748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2751074A Expired GB1471755A (en) | 1974-06-20 | 1974-06-20 | Derivatives of digoxin and digotoxin |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4029880A (enExample) |
| JP (1) | JPS5851626B2 (enExample) |
| CA (1) | CA1070670A (enExample) |
| DE (1) | DE2526984C3 (enExample) |
| FR (1) | FR2275483A1 (enExample) |
| GB (1) | GB1471755A (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5053497A (en) * | 1984-12-28 | 1991-10-01 | Technion Instruments Corporation | Phospholipid conjugates and their preparation |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4595656A (en) * | 1984-01-06 | 1986-06-17 | Becton Dickinson & Company | Coupling agents and products produced therefrom |
| US4670406A (en) * | 1984-01-06 | 1987-06-02 | Becton Dickinson And Company | Tracers for use in assays |
| DE3583015D1 (de) * | 1984-12-28 | 1991-07-04 | Technicon Instr | Phospholipidkonjugate und deren herstellung. |
| CA1301685C (en) * | 1987-07-08 | 1992-05-26 | Deng R. Hwang | Phospholipid conjugates and their preparation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1441253A (en) * | 1972-06-22 | 1976-06-30 | Wellcome Found | Reagents for the assay of cardiac glycosides |
| US3925355A (en) * | 1974-03-01 | 1975-12-09 | Corning Glass Works | Labelled digoxin derivatives for radioimmunoassay |
-
1974
- 1974-06-20 GB GB2751074A patent/GB1471755A/en not_active Expired
-
1975
- 1975-06-17 FR FR7518872A patent/FR2275483A1/fr active Granted
- 1975-06-17 CA CA229,511A patent/CA1070670A/en not_active Expired
- 1975-06-18 JP JP50075012A patent/JPS5851626B2/ja not_active Expired
- 1975-06-18 DE DE2526984A patent/DE2526984C3/de not_active Expired
- 1975-06-19 US US05/588,165 patent/US4029880A/en not_active Expired - Lifetime
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5053497A (en) * | 1984-12-28 | 1991-10-01 | Technion Instruments Corporation | Phospholipid conjugates and their preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2526984A1 (de) | 1976-01-08 |
| JPS5851626B2 (ja) | 1983-11-17 |
| US4029880A (en) | 1977-06-14 |
| FR2275483A1 (fr) | 1976-01-16 |
| DE2526984B2 (de) | 1981-04-23 |
| FR2275483B1 (enExample) | 1980-05-16 |
| CA1070670A (en) | 1980-01-29 |
| DE2526984C3 (de) | 1982-03-18 |
| JPS5119119A (en) | 1976-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |