GB1470675A - 1,2,3,4-tetrahydroisoquinoline derivatives and the preparation thereof - Google Patents

1,2,3,4-tetrahydroisoquinoline derivatives and the preparation thereof

Info

Publication number
GB1470675A
GB1470675A GB3220674A GB3220674A GB1470675A GB 1470675 A GB1470675 A GB 1470675A GB 3220674 A GB3220674 A GB 3220674A GB 3220674 A GB3220674 A GB 3220674A GB 1470675 A GB1470675 A GB 1470675A
Authority
GB
United Kingdom
Prior art keywords
july
formula
tetrahydroisoquinoline derivatives
sulphamoyl
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3220674A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP8200473A external-priority patent/JPS5637983B2/ja
Priority claimed from JP8200373A external-priority patent/JPS572707B2/ja
Priority claimed from JP8598773A external-priority patent/JPS5734275B2/ja
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of GB1470675A publication Critical patent/GB1470675A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

1470675 1,2,3,4-Tetrahydroisoquinoline derivatives FUJISAWA PHARMACEUTICAL CO Ltd 19 July 1974 [20 July 1973 (2) 30 July 1973] 32206/74 Heading C2C Novel 1,2,3,4-tetrahydroisoquinoline derivatives having the formula wherein R 1 and R 2 are hydrogen or (C 1 -C 6 ) alkyl; R 3 is phenyl substituted by (C 2 -C 6 ) alkenyloxy, mercapto, (C 1 -C 6 ) alkylthio, sulphamoyl, mono- or di-substituted sulphamoyl, or a heterocyclic group; R 4 and R 5 are hydroxy or protected hydroxy and X is oxygen or sulphur, and pharmaceutically acceptable salts thereof, are prepared by reacting a compound of the formula or a salt thereof, with an aldehyde of the formula R 3 .X.CH 2 CHO. The novel compounds possess pharmaceutical properties.
GB3220674A 1973-07-20 1974-07-19 1,2,3,4-tetrahydroisoquinoline derivatives and the preparation thereof Expired GB1470675A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8200473A JPS5637983B2 (en) 1973-07-20 1973-07-20
JP8200373A JPS572707B2 (en) 1973-07-20 1973-07-20
JP8598773A JPS5734275B2 (en) 1973-07-30 1973-07-30

Publications (1)

Publication Number Publication Date
GB1470675A true GB1470675A (en) 1977-04-21

Family

ID=27303776

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3220674A Expired GB1470675A (en) 1973-07-20 1974-07-19 1,2,3,4-tetrahydroisoquinoline derivatives and the preparation thereof

Country Status (11)

Country Link
AR (1) AR204327A1 (en)
CA (1) CA1035359A (en)
CH (1) CH605775A5 (en)
DE (1) DE2434310A1 (en)
DK (1) DK389874A (en)
ES (1) ES428442A1 (en)
FR (1) FR2237634B1 (en)
GB (1) GB1470675A (en)
IE (1) IE39724B1 (en)
NL (1) NL7409805A (en)
SE (1) SE420600B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118690A (en) * 1989-09-20 1992-06-02 John Wyeth & Brother Limited Pharmaceutical tetrahydroisoquinolines

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5734275B2 (en) 1973-07-30 1982-07-22
GB8807922D0 (en) * 1988-04-05 1988-05-05 Fujisawa Pharmaceutical Co Isoquinoline compound & process for preparation thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1145254A (en) * 1965-03-18 1969-03-12 Bristol Myers Co Novel tetrahydroisoquinoline derivatives and a process for the preparation thereof
US3389141A (en) * 1966-05-16 1968-06-18 Bristol Myers Co 1-beta-aryloxyethyltetrahydro-isoquinolines
FR2119989B1 (en) * 1970-12-29 1975-10-10 Fujisawa Pharmaceutical Co

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118690A (en) * 1989-09-20 1992-06-02 John Wyeth & Brother Limited Pharmaceutical tetrahydroisoquinolines

Also Published As

Publication number Publication date
CA1035359A (en) 1978-07-25
ES428442A1 (en) 1977-01-01
SE420600B (en) 1981-10-19
FR2237634B1 (en) 1978-06-30
FR2237634A1 (en) 1975-02-14
AU7145674A (en) 1976-01-22
IE39724L (en) 1975-01-20
CH605775A5 (en) 1978-10-13
IE39724B1 (en) 1978-12-20
AR204327A1 (en) 1975-12-22
NL7409805A (en) 1975-01-22
DK389874A (en) 1975-03-17
DE2434310A1 (en) 1975-02-06
SE7409470L (en) 1975-01-21

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee