GB1470329A - Antibiotic derivatives of xk-62-2 and method of production thereof - Google Patents

Antibiotic derivatives of xk-62-2 and method of production thereof

Info

Publication number
GB1470329A
GB1470329A GB5378074A GB5378074A GB1470329A GB 1470329 A GB1470329 A GB 1470329A GB 5378074 A GB5378074 A GB 5378074A GB 5378074 A GB5378074 A GB 5378074A GB 1470329 A GB1470329 A GB 1470329A
Authority
GB
United Kingdom
Prior art keywords
antibiotic
production
formula
image
antibiotic derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5378074A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
KH Neochem Co Ltd
Abbott Laboratories
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd, Abbott Laboratories filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of GB1470329A publication Critical patent/GB1470329A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C07H15/236—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2 a saccharide radical being substituted by an alkylamino radical in position 3 and by two substituents different from hydrogen in position 4, e.g. gentamicin complex, sisomicin, verdamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Acylation of the antibiotic which is known under the name XK-62-2 and has the formula A <IMAGE> in which R6 is hydrogen with a compound of the formula Y1Y2N-CH2-CH2-CHOH-COZ initially results in a mixture of various acylated compounds from which the required compound with the group <IMAGE> is isolated, and the protective group Y2 is removed before or after the isolation. The antibiotic has a broad spectrum of antibacterial activity, especially against Escherichia coli KY 8327 and 8348.
GB5378074A 1973-12-12 1974-12-12 Antibiotic derivatives of xk-62-2 and method of production thereof Expired GB1470329A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13782773A JPS5635193B2 (en) 1973-12-12 1973-12-12

Publications (1)

Publication Number Publication Date
GB1470329A true GB1470329A (en) 1977-04-14

Family

ID=15207762

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5378074A Expired GB1470329A (en) 1973-12-12 1974-12-12 Antibiotic derivatives of xk-62-2 and method of production thereof

Country Status (15)

Country Link
JP (1) JPS5635193B2 (en)
AT (1) AT337894B (en)
CA (1) CA1030530A (en)
CH (1) CH618180A5 (en)
DE (1) DE2458921C3 (en)
DK (1) DK644174A (en)
ES (1) ES432862A1 (en)
FR (1) FR2254565B1 (en)
GB (1) GB1470329A (en)
IN (1) IN141068B (en)
NL (1) NL7416211A (en)
NO (1) NO139562C (en)
PH (1) PH15160A (en)
SE (1) SE417825B (en)
ZA (1) ZA747907B (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383596B2 (en) 2007-11-21 2013-02-26 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8492354B2 (en) 2009-05-15 2013-07-23 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8524675B2 (en) 2009-05-15 2013-09-03 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8524689B2 (en) 2009-05-15 2013-09-03 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8653042B2 (en) 2009-05-15 2014-02-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8658606B2 (en) 2009-05-15 2014-02-25 Achaogen, Inc. Antibacterial aminoglycoside analogs

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8383596B2 (en) 2007-11-21 2013-02-26 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8822424B2 (en) 2007-11-21 2014-09-02 Achaogen, Inc. Antibacterial aminoglycoside analogs
US9266919B2 (en) 2007-11-21 2016-02-23 Achaogen, Inc. Antibacterial aminoglycoside analogs
US9688711B2 (en) 2007-11-21 2017-06-27 Achaogen, Inc. Antibacterial aminoglycoside analogs
US11117915B2 (en) 2007-11-21 2021-09-14 Cipla USA, Inc. Antibacterial aminoglycoside analogs
US8492354B2 (en) 2009-05-15 2013-07-23 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8524675B2 (en) 2009-05-15 2013-09-03 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8524689B2 (en) 2009-05-15 2013-09-03 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8653042B2 (en) 2009-05-15 2014-02-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
US8658606B2 (en) 2009-05-15 2014-02-25 Achaogen, Inc. Antibacterial aminoglycoside analogs
USRE47741E1 (en) 2009-05-15 2019-11-26 Achaogen, Inc. Antibacterial aminoglycoside analogs

Also Published As

Publication number Publication date
NO744447L (en) 1975-07-07
FR2254565A1 (en) 1975-07-11
PH15160A (en) 1982-08-27
JPS5088050A (en) 1975-07-15
DE2458921A1 (en) 1975-06-26
ATA991874A (en) 1976-11-15
ZA747907B (en) 1976-01-28
DE2458921C3 (en) 1978-04-06
SE7415609L (en) 1975-06-13
NL7416211A (en) 1975-06-16
IN141068B (en) 1977-01-15
SE417825B (en) 1981-04-13
NO139562C (en) 1979-04-04
NO139562B (en) 1978-12-27
CH618180A5 (en) 1980-07-15
AU7636074A (en) 1976-06-17
DE2458921B2 (en) 1977-08-04
JPS5635193B2 (en) 1981-08-15
ES432862A1 (en) 1977-04-01
FR2254565B1 (en) 1979-08-10
CA1030530A (en) 1978-05-02
AT337894B (en) 1977-07-25
DK644174A (en) 1975-08-25

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee