GB1469381A - Process of preparing 1,3-bis-2-chloro-ethyl-1-nitrosourea - Google Patents
Process of preparing 1,3-bis-2-chloro-ethyl-1-nitrosoureaInfo
- Publication number
- GB1469381A GB1469381A GB1363475A GB1363475A GB1469381A GB 1469381 A GB1469381 A GB 1469381A GB 1363475 A GB1363475 A GB 1363475A GB 1363475 A GB1363475 A GB 1363475A GB 1469381 A GB1469381 A GB 1469381A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bis
- nitrosourea
- chloroethyl
- ethyl
- chloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 abstract 2
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- LZDSILRDTDCIQT-UHFFFAOYSA-N dinitrogen trioxide Chemical compound [O-][N+](=O)N=O LZDSILRDTDCIQT-UHFFFAOYSA-N 0.000 abstract 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 239000004202 carbamide Substances 0.000 abstract 1
- LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 abstract 1
- 239000012430 organic reaction media Substances 0.000 abstract 1
- 239000012429 reaction media Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/66—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to halogen atoms or to nitro or nitroso groups
- C07C275/68—N-nitroso ureas
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/523,334 US4028410A (en) | 1974-11-13 | 1974-11-13 | Process of preparing 1,3-bis(2-chloroethyl)-1-nitrosourea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1469381A true GB1469381A (en) | 1977-04-06 |
Family
ID=24084603
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1363475A Expired GB1469381A (en) | 1974-11-13 | 1975-04-03 | Process of preparing 1,3-bis-2-chloro-ethyl-1-nitrosourea |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4028410A (en, 2012) |
| JP (1) | JPS5156414A (en, 2012) |
| CA (1) | CA1082223A (en, 2012) |
| CH (1) | CH598204A5 (en, 2012) |
| DE (1) | DE2528365A1 (en, 2012) |
| FR (1) | FR2291187A1 (en, 2012) |
| GB (1) | GB1469381A (en, 2012) |
| SE (1) | SE7504719L (en, 2012) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0902015A1 (en) * | 1997-09-13 | 1999-03-17 | Johnson Matthey Public Limited Company | Process for the preparation of nitrosourea compounds |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56120662A (en) * | 1980-02-28 | 1981-09-22 | Kowa Co | Novel nitrosourea derivative and its preparation |
| JPS57116043A (en) * | 1981-01-12 | 1982-07-19 | Tetsuo Suami | New nitrosourea derivative and its preparation |
| US20040072889A1 (en) * | 1997-04-21 | 2004-04-15 | Pharmacia Corporation | Method of using a COX-2 inhibitor and an alkylating-type antineoplastic agent as a combination therapy in the treatment of neoplasia |
| WO2007085026A2 (en) * | 2006-01-20 | 2007-07-26 | The Board Of Regents Of The University Of Texas System | Compositions and methods for the direct therapy of tumors |
| JP6325139B2 (ja) | 2016-03-02 | 2018-05-16 | ネルファルマ・エッセ・エッルレ・エッレ | カルムスチンの安全で効率的な製造方法 |
| WO2017154019A1 (en) * | 2016-03-11 | 2017-09-14 | Msn Laboratories Private Limited | An improved process for the preparation of 1,3-bis(2-chloroethyl)-1-nitrosourea |
| EP3442941B1 (en) | 2016-04-16 | 2021-12-01 | Intas Pharmaceuticals Limited | Process for preparation of carmustine |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3465025A (en) * | 1966-11-17 | 1969-09-02 | Allied Chem | Process for the preparation of isocyanates |
-
1974
- 1974-11-13 US US05/523,334 patent/US4028410A/en not_active Expired - Lifetime
-
1975
- 1975-04-03 GB GB1363475A patent/GB1469381A/en not_active Expired
- 1975-04-23 SE SE7504719A patent/SE7504719L/xx unknown
- 1975-04-29 FR FR7513437A patent/FR2291187A1/fr active Granted
- 1975-05-14 CA CA226,863A patent/CA1082223A/en not_active Expired
- 1975-05-19 JP JP50059538A patent/JPS5156414A/ja active Pending
- 1975-06-25 DE DE19752528365 patent/DE2528365A1/de not_active Withdrawn
- 1975-07-04 CH CH881175A patent/CH598204A5/xx not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0902015A1 (en) * | 1997-09-13 | 1999-03-17 | Johnson Matthey Public Limited Company | Process for the preparation of nitrosourea compounds |
| US6096923A (en) * | 1997-09-13 | 2000-08-01 | Johnson Matthey Public Limited Company | Process for the preparation of nitrosourea compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1082223A (en) | 1980-07-22 |
| US4028410A (en) | 1977-06-07 |
| AU8007675A (en) | 1976-10-14 |
| DE2528365A1 (de) | 1976-05-20 |
| SE7504719L (sv) | 1976-05-14 |
| FR2291187A1 (fr) | 1976-06-11 |
| CH598204A5 (en, 2012) | 1978-04-28 |
| JPS5156414A (en) | 1976-05-18 |
| FR2291187B1 (en, 2012) | 1980-04-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 746 | Register noted 'licences of right' (sect. 46/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |