GB1465769A - Carbamates of ergolines - Google Patents
Carbamates of ergolinesInfo
- Publication number
- GB1465769A GB1465769A GB2311974A GB2311974A GB1465769A GB 1465769 A GB1465769 A GB 1465769A GB 2311974 A GB2311974 A GB 2311974A GB 2311974 A GB2311974 A GB 2311974A GB 1465769 A GB1465769 A GB 1465769A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- compound
- formula
- substituted
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000004657 carbamic acid derivatives Chemical class 0.000 title 1
- RHGUXDUPXYFCTE-ZWNOBZJWSA-N ergoline Chemical class C1=CC([C@@H]2[C@H](NCCC2)C2)=C3C2=CNC3=C1 RHGUXDUPXYFCTE-ZWNOBZJWSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 Ergoline carbamates Chemical class 0.000 abstract 3
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 230000002048 spasmolytic effect Effects 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D457/00—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid
- C07D457/02—Heterocyclic compounds containing indolo [4, 3-f, g] quinoline ring systems, e.g. derivatives of ergoline, of the formula:, e.g. lysergic acid with hydrocarbon or substituted hydrocarbon radicals, attached in position 8
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT24513/73A IT1048122B (it) | 1973-05-23 | 1973-05-23 | Carbammati di ergoline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1465769A true GB1465769A (en) | 1977-03-02 |
Family
ID=11213802
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2311974A Expired GB1465769A (en) | 1973-05-23 | 1974-05-23 | Carbamates of ergolines |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3944582A (enExample) |
| JP (2) | JPS5040598A (enExample) |
| BE (1) | BE815362A (enExample) |
| CA (1) | CA1005440A (enExample) |
| DE (1) | DE2424540A1 (enExample) |
| FR (1) | FR2230364B1 (enExample) |
| GB (1) | GB1465769A (enExample) |
| IT (1) | IT1048122B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4057635A (en) * | 1973-05-23 | 1977-11-08 | Simes Societa Italiana Medicinali E Sintetici S.P.A. | Carbamates of ergolines and therapeutic compositions therewith |
| CH619709A5 (en) * | 1975-03-14 | 1980-10-15 | Siphar Sa | Process for the preparation of carbamates of 2-halogenoergolines and 2-halogenoergolenes |
| US4199579A (en) * | 1975-03-14 | 1980-04-22 | Siphar S. A. | Carbamates of 2-haloergolines and 2-haloergolenes and process for the preparation thereof |
| IT1158162B (it) * | 1977-12-22 | 1987-02-18 | Sandoz Ag | Composizioni farmaceutiche a base di derivati dell'ergolena e dell'ergolina |
| IT1193467B (it) * | 1978-01-26 | 1988-07-08 | Simes | Carbammati di omolisergoli (8 beta-idrossietilergoline) |
| GB9625895D0 (en) | 1996-12-13 | 1997-01-29 | Riley Patrick A | Novel compound useful as therapeutic agents and assay reagents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1047164A (en) * | 1962-07-05 | 1966-11-02 | Farmaceutici Italia | Ergoline ó derivatives |
| DE1936410A1 (de) * | 1969-07-17 | 1971-02-11 | Hoechst Ag | O-Acyl-lysergole und Verfahren zu ihrer Herstellung |
| AT401817B (de) * | 1993-12-01 | 1996-12-27 | Rieger Walter | Verfahren zum brennen von keramischen formlingen und anlage zur durchführung des verfahrens |
-
1973
- 1973-05-23 IT IT24513/73A patent/IT1048122B/it active
-
1974
- 1974-05-20 US US05/471,701 patent/US3944582A/en not_active Expired - Lifetime
- 1974-05-21 BE BE144594A patent/BE815362A/xx unknown
- 1974-05-21 DE DE2424540A patent/DE2424540A1/de active Pending
- 1974-05-21 FR FR7417699A patent/FR2230364B1/fr not_active Expired
- 1974-05-23 JP JP49058336A patent/JPS5040598A/ja active Pending
- 1974-05-23 GB GB2311974A patent/GB1465769A/en not_active Expired
- 1974-05-23 CA CA200,669A patent/CA1005440A/en not_active Expired
-
1976
- 1976-10-15 JP JP51122990A patent/JPS5278899A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2230364A1 (enExample) | 1974-12-20 |
| DE2424540A1 (de) | 1974-12-12 |
| US3944582A (en) | 1976-03-16 |
| CA1005440A (en) | 1977-02-15 |
| FR2230364B1 (enExample) | 1977-07-08 |
| IT1048122B (it) | 1980-11-20 |
| JPS5040598A (enExample) | 1975-04-14 |
| BE815362A (fr) | 1974-09-16 |
| JPS5278899A (en) | 1977-07-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |