GB1464207A - Prostaglandins - Google Patents
ProstaglandinsInfo
- Publication number
- GB1464207A GB1464207A GB3142275A GB3142275A GB1464207A GB 1464207 A GB1464207 A GB 1464207A GB 3142275 A GB3142275 A GB 3142275A GB 3142275 A GB3142275 A GB 3142275A GB 1464207 A GB1464207 A GB 1464207A
- Authority
- GB
- United Kingdom
- Prior art keywords
- esters
- prostaglandins
- formula
- corresponding acids
- pnitrophenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940094443 oxytocics prostaglandins Drugs 0.000 title abstract 3
- 150000003180 prostaglandins Chemical class 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 abstract 4
- -1 p-biphenylyl Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1464207 Esters of prostaglandins UPJOHN CO 28 July 1975 [14 Aug 1974] 31422/75 Heading C2C The invention comprises optically active esters of prostaglandins of the formula or racemates thereof, wherein m is R 1 is phenyl, p-bromophenyl, p-biphenylyl, pnitrophenyl, p-benzamidophenyl or 2-naphthyl; and R 2 is H or benzoyl, and their preparation by reacting the corresponding acids with compounds of the formula wherein Hal is Cl, Br or I, in the presence of tertiary amines and solvents. Pharmaceutical compositions, suitable for oral, sublingual, buccal, intravaginal, intrauterine, rectal or topical administration, contain the above esters and pharmaceutically acceptable carriers. The esters possess similar pharmacological properties to the corresponding acids.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49724174A | 1974-08-14 | 1974-08-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1464207A true GB1464207A (en) | 1977-02-09 |
Family
ID=23976030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3142275A Expired GB1464207A (en) | 1974-08-14 | 1975-07-28 | Prostaglandins |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS5139651A (en) |
| BE (1) | BE832456A (en) |
| DE (1) | DE2535662A1 (en) |
| FR (1) | FR2281749A1 (en) |
| GB (1) | GB1464207A (en) |
| NL (1) | NL7509072A (en) |
| SE (1) | SE7508935L (en) |
| ZA (1) | ZA754675B (en) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2322655C2 (en) * | 1973-05-03 | 1984-06-20 | Schering AG, 1000 Berlin und 4709 Bergkamen | Prostaglandin F? 2???? Esters, process for their preparation and their use for the purification of prostaglandin F? 2???? |
-
1975
- 1975-07-21 ZA ZA00754675A patent/ZA754675B/en unknown
- 1975-07-28 GB GB3142275A patent/GB1464207A/en not_active Expired
- 1975-07-30 NL NL7509072A patent/NL7509072A/en not_active Application Discontinuation
- 1975-07-31 JP JP50092665A patent/JPS5139651A/en active Pending
- 1975-08-08 SE SE7508935A patent/SE7508935L/en unknown
- 1975-08-09 DE DE19752535662 patent/DE2535662A1/en not_active Withdrawn
- 1975-08-13 FR FR7525274A patent/FR2281749A1/en active Granted
- 1975-08-14 BE BE159227A patent/BE832456A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL7509072A (en) | 1976-02-17 |
| DE2535662A1 (en) | 1976-03-04 |
| ZA754675B (en) | 1976-06-30 |
| AU8339575A (en) | 1977-01-27 |
| FR2281749A1 (en) | 1976-03-12 |
| JPS5139651A (en) | 1976-04-02 |
| BE832456A (en) | 1976-02-16 |
| SE7508935L (en) | 1976-02-16 |
| FR2281749B1 (en) | 1978-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 48S | Specification amended (sect. 8/1949) | ||
| SP | Amendment (slips) printed | ||
| PCNP | Patent ceased through non-payment of renewal fee |