GB1463669A - Tetrahydroquinoline derivatives - Google Patents

Tetrahydroquinoline derivatives

Info

Publication number
GB1463669A
GB1463669A GB5224374A GB5224374A GB1463669A GB 1463669 A GB1463669 A GB 1463669A GB 5224374 A GB5224374 A GB 5224374A GB 5224374 A GB5224374 A GB 5224374A GB 1463669 A GB1463669 A GB 1463669A
Authority
GB
United Kingdom
Prior art keywords
compounds
march
lithio
compound
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5224374A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Priority to GB5224374A priority Critical patent/GB1463669A/en
Priority to CY104175A priority patent/CY1041A/en
Priority to US05/624,039 priority patent/US4029668A/en
Publication of GB1463669A publication Critical patent/GB1463669A/en
Priority to KE303180A priority patent/KE3031A/en
Priority to HK10182A priority patent/HK10182A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

1463669 Methyl-substituted 5,6,7,8-tetrahydroquinoline - 8 - thiocarboxamides JOHN WYETH & BRO Ltd 25 March 1975 [27 March 1974 3 Dec 1974] 13515/74 and 52243/74 Addition to 1432378 Headings C2C and C2J The invention comprises compounds of formula and their pharmaceutically acceptable acid addition salts, wherein one of R<SP>6</SP> and R<SP>7</SP> is Me, while R<SP>1</SP> and R<SP>2</SP> as well as the other of R<SP>6</SP> and R<SP>7</SP> are each H or Me. These compounds are either prepared by the synthetic method of the parent Specification, namely 8-lithio-compound #8 - carboxylic acid#8 - methyl carboxylate# 8 - carboxamide#8 - thiocarboxamide, or the lithio compound is reacted with Me 3 SiNCS, followed by aq. HCl. Therapeutic compositions having anti-ulcer and/or anti-secretory activity comprise compounds of the above formula.
GB5224374A 1972-10-21 1974-12-03 Tetrahydroquinoline derivatives Expired GB1463669A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB5224374A GB1463669A (en) 1974-03-27 1974-12-03 Tetrahydroquinoline derivatives
CY104175A CY1041A (en) 1974-03-27 1975-03-25 Tetrahydroquinoline derivatives
US05/624,039 US4029668A (en) 1972-10-21 1975-10-20 Cyclopenteno[b]pyridine derivatives
KE303180A KE3031A (en) 1974-03-27 1980-03-05 Tetrahydroquinoline derivatives
HK10182A HK10182A (en) 1974-03-27 1982-03-04 Tetrahydroquinoline derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1351574 1974-03-27
GB5224374A GB1463669A (en) 1974-03-27 1974-12-03 Tetrahydroquinoline derivatives

Publications (1)

Publication Number Publication Date
GB1463669A true GB1463669A (en) 1977-02-02

Family

ID=26249823

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5224374A Expired GB1463669A (en) 1972-10-21 1974-12-03 Tetrahydroquinoline derivatives

Country Status (4)

Country Link
CY (1) CY1041A (en)
GB (1) GB1463669A (en)
HK (1) HK10182A (en)
KE (1) KE3031A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2122615A (en) * 1982-06-25 1984-01-18 Wyeth John & Brother Ltd Preparation of fused carboxylic ring derivatives of pyridine
EP0054384B1 (en) * 1980-12-09 1984-06-27 JOHN WYETH &amp; BROTHER LIMITED Process for preparing pyridine derivatives
US4539406A (en) * 1982-06-25 1985-09-03 John Wyeth & Brother Limited Preparation of fused carbocyclic ring derivatives of pyridine

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0054384B1 (en) * 1980-12-09 1984-06-27 JOHN WYETH &amp; BROTHER LIMITED Process for preparing pyridine derivatives
GB2122615A (en) * 1982-06-25 1984-01-18 Wyeth John & Brother Ltd Preparation of fused carboxylic ring derivatives of pyridine
US4539406A (en) * 1982-06-25 1985-09-03 John Wyeth & Brother Limited Preparation of fused carbocyclic ring derivatives of pyridine

Also Published As

Publication number Publication date
CY1041A (en) 1980-08-01
HK10182A (en) 1982-03-12
KE3031A (en) 1980-03-21

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Legal Events

Date Code Title Description
PS Patent sealed