GB1463583A - Halo and hydroxy compounds - Google Patents

Halo and hydroxy compounds

Info

Publication number
GB1463583A
GB1463583A GB1538976A GB1538976A GB1463583A GB 1463583 A GB1463583 A GB 1463583A GB 1538976 A GB1538976 A GB 1538976A GB 1538976 A GB1538976 A GB 1538976A GB 1463583 A GB1463583 A GB 1463583A
Authority
GB
United Kingdom
Prior art keywords
substituted
alkyl
radical
radicals
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1538976A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Priority to GB1538976A priority Critical patent/GB1463583A/en
Publication of GB1463583A publication Critical patent/GB1463583A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/24—Oxygen atoms attached in position 8
    • C07D215/26—Alcohols; Ethers thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/40—Nitrogen atoms attached in position 8

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1463583 Tetrahydro - quinolines JOHN WYETH & BRO Ltd 26 Feb 1975 [5 March 1974] 15389/76 Divided out of 1463582 Heading C2C The invention comprises novel compounds or an acid addition salt thereof, wherein R<SP>1</SP>, R<SP>2</SP> and R<SP>3</SP> are the same or different and represent a hydrogen atom, a trifluoromethyl group, or an alkyl, aralkyl or aryl radical, any of which radicals may be substituted by alkyl, alkoxy, nitro or trifluoromethyl and an aryl radical or the aryl portion of an aralkyl radical may be substituted by halogen or R<SP>1</SP>, R<SP>2</SP> taken together represent an alkylene chain -CH 2 (CH 2 ) n CH 2 - wherein n is 1, 2 or 3, R<SP>4</SP> represents hydrogen or single or multiple substitution by alkyl, aralkyl or aryl radicals any of which radicals may be substituted by alkyl, alkoxy, nitro or trifluoromethyl and an aryl radical or the aryl portion of an aralkyl radical may be substituted by halogen and when R<SP>1</SP> and R<SP>2</SP> taken together form an alkylene chain the resulting ring may be substituted by one or more R<SP>4</SP> radicals as defined above, Y is chloro, bromo or hydroxy, with the proviso that either at least one of R<SP>2</SP>, R<SP>3</SP> and R<SP>4</SP> is other than hydrogen or if R<SP>1</SP> and R<SP>2</SP> are joined to form an alkylene chain in which n is 2 then the resulting ring is substituted by an R<SP>4</SP> radical which is other than hydrogen, and m is 1, 2 or 3 with the proviso that when R<SP>1</SP> and R<SP>2</SP> taken together represent an alkylene chain then n is equal to m. The hydroxy compounds (Y is OH) are made by treating N-oxides of appropriate compounds related to (I) with an acylating agent and thereafter rearranging and hydrolysing the products obtained; the chloro and bromo compounds (Y is Cl or Br) are obtained from the hydroxy compounds or by treating N-oxides of (I) where Y is H with an alkyl sulphonyl halide.
GB1538976A 1974-03-05 1974-03-05 Halo and hydroxy compounds Expired GB1463583A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1538976A GB1463583A (en) 1974-03-05 1974-03-05 Halo and hydroxy compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB1538976A GB1463583A (en) 1974-03-05 1974-03-05 Halo and hydroxy compounds

Publications (1)

Publication Number Publication Date
GB1463583A true GB1463583A (en) 1977-02-02

Family

ID=10058295

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1538976A Expired GB1463583A (en) 1974-03-05 1974-03-05 Halo and hydroxy compounds

Country Status (1)

Country Link
GB (1) GB1463583A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075303A (en) * 1989-04-07 1991-12-24 John Wyeth & Brother Limited Pyridine derivatives
US5194439A (en) * 1990-04-06 1993-03-16 John Wyeth & Brother Limited N-(2,3-dihydro-1,4-benzodioxinyl)-N-substituted aminopyrido-fused cycloalkanes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075303A (en) * 1989-04-07 1991-12-24 John Wyeth & Brother Limited Pyridine derivatives
US5194439A (en) * 1990-04-06 1993-03-16 John Wyeth & Brother Limited N-(2,3-dihydro-1,4-benzodioxinyl)-N-substituted aminopyrido-fused cycloalkanes

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Legal Events

Date Code Title Description
PS Patent sealed
746 Register noted 'licences of right' (sect. 46/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19950225