GB1456674A - Neomycin derivatives - Google Patents
Neomycin derivativesInfo
- Publication number
- GB1456674A GB1456674A GB5642173A GB5642173A GB1456674A GB 1456674 A GB1456674 A GB 1456674A GB 5642173 A GB5642173 A GB 5642173A GB 5642173 A GB5642173 A GB 5642173A GB 1456674 A GB1456674 A GB 1456674A
- Authority
- GB
- United Kingdom
- Prior art keywords
- neomycin
- general formula
- pharmaceutically acceptable
- formulμ
- toxic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229930193140 Neomycin Natural products 0.000 title abstract 6
- 229960004927 neomycin Drugs 0.000 title abstract 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 231100000252 nontoxic Toxicity 0.000 abstract 3
- 230000003000 nontoxic effect Effects 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 abstract 2
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 abstract 2
- -1 L-(-)-γ- amino-α-hydroxy-butyryl group Chemical group 0.000 abstract 1
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- HSDAJNMJOMSNEV-UHFFFAOYSA-N benzyl chloroformate Chemical compound ClC(=O)OCC1=CC=CC=C1 HSDAJNMJOMSNEV-UHFFFAOYSA-N 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 150000001718 carbodiimides Chemical class 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 229960003704 framycetin Drugs 0.000 abstract 1
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- PGBHMTALBVVCIT-VZXHOKRSSA-N neomycin C Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VZXHOKRSSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229960002317 succinimide Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
- C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
- C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
- C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
- C07H15/232—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31245272A | 1972-12-06 | 1972-12-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1456674A true GB1456674A (en) | 1976-11-24 |
Family
ID=23211510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5642173A Expired GB1456674A (en) | 1972-12-06 | 1973-12-05 | Neomycin derivatives |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5719120B2 (enrdf_load_stackoverflow) |
| DE (1) | DE2360946A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2209546B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1456674A (enrdf_load_stackoverflow) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007064954A3 (en) * | 2005-12-02 | 2007-08-16 | Isis Pharmaceuticals Inc | Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents |
| US7943749B2 (en) | 2004-11-05 | 2011-05-17 | Isis Pharmaceuticals, Inc. | Antimicrobial 2-deoxystreptamine compounds |
| US8318685B2 (en) | 2010-11-17 | 2012-11-27 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| US8367625B2 (en) | 2008-10-09 | 2013-02-05 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| US8372813B2 (en) | 2008-10-09 | 2013-02-12 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| US8377896B2 (en) | 2008-09-10 | 2013-02-19 | Isis Pharmaceuticals, Inc | Antibacterial 4,6-substituted 6′, 6″ and 1 modified aminoglycoside analogs |
| US8399419B2 (en) | 2008-09-10 | 2013-03-19 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| US8481502B2 (en) | 2009-10-09 | 2013-07-09 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6482802B1 (en) * | 1998-05-11 | 2002-11-19 | Endowment For Research In Human Biology, Inc. | Use of neomycin for treating angiogenesis-related diseases |
| US20080300199A1 (en) * | 2007-04-10 | 2008-12-04 | Achaogen Inc. | Antibacterial 1,4,5-substituted aminoglycoside analogs |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK122735B (da) * | 1968-03-25 | 1972-04-04 | Parke Davis & Co | Fremgangsmåde til fremstilling af et antibakterielt virksomt stof, ambutyrosin, dets komponenter ambutyrosin A og B eller syreadditionssalte, eller tetra-N-acetylderivater eller tetra-N-methansulfonatderivater deraf. |
-
1973
- 1973-12-04 FR FR7343191A patent/FR2209546B1/fr not_active Expired
- 1973-12-05 JP JP13525473A patent/JPS5719120B2/ja not_active Expired
- 1973-12-05 GB GB5642173A patent/GB1456674A/en not_active Expired
- 1973-12-06 DE DE2360946A patent/DE2360946A1/de not_active Withdrawn
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7943749B2 (en) | 2004-11-05 | 2011-05-17 | Isis Pharmaceuticals, Inc. | Antimicrobial 2-deoxystreptamine compounds |
| WO2007064954A3 (en) * | 2005-12-02 | 2007-08-16 | Isis Pharmaceuticals Inc | Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents |
| US7893039B2 (en) | 2005-12-02 | 2011-02-22 | Isis Pharmaceuticals, Inc. | Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents |
| US8114856B2 (en) | 2005-12-02 | 2012-02-14 | Isis Pharmaceuticals, Inc. | Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents |
| AU2006320374B2 (en) * | 2005-12-02 | 2012-08-30 | Isis Pharmaceuticals, Inc. | Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents |
| US8569264B2 (en) | 2005-12-02 | 2013-10-29 | Isis Pharmaceuticals, Inc. | Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents |
| US8399419B2 (en) | 2008-09-10 | 2013-03-19 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| US8377896B2 (en) | 2008-09-10 | 2013-02-19 | Isis Pharmaceuticals, Inc | Antibacterial 4,6-substituted 6′, 6″ and 1 modified aminoglycoside analogs |
| US8742078B2 (en) | 2008-09-10 | 2014-06-03 | Isis Pharmaceuticals, Inc. | Antibacterial 4,6-substituted 6′, 6″ and 1 modified aminoglycoside analogs |
| US8372813B2 (en) | 2008-10-09 | 2013-02-12 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| US8367625B2 (en) | 2008-10-09 | 2013-02-05 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| US8481502B2 (en) | 2009-10-09 | 2013-07-09 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| US8318685B2 (en) | 2010-11-17 | 2012-11-27 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
| US8653041B2 (en) | 2010-11-17 | 2014-02-18 | Achaogen, Inc. | Antibacterial aminoglycoside analogs |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2209546A1 (enrdf_load_stackoverflow) | 1974-07-05 |
| DE2360946A1 (de) | 1974-06-20 |
| JPS5719120B2 (enrdf_load_stackoverflow) | 1982-04-20 |
| JPS4992044A (enrdf_load_stackoverflow) | 1974-09-03 |
| FR2209546B1 (enrdf_load_stackoverflow) | 1977-09-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0544000T3 (da) | N-acetylcarboxymethylchitosanderivater og fremgangsmåde til fremstilling deraf. | |
| ES468173A1 (es) | Un procedimiento para la preparacion de derivados de morfina | |
| GB1456674A (en) | Neomycin derivatives | |
| GB1444733A (en) | Gentlamicin derivatives and process for their production | |
| GB1212460A (en) | Naphthacene derivatives | |
| GB1482099A (en) | Sulphonamido derivatives | |
| GB1507118A (en) | Antibiotic derivatives of 3',4'-dideoxykanamycin b and the preparation thereof | |
| GB1467401A (en) | Kanamycin derivatives | |
| GB1441202A (en) | 1-n-isoserylkanamycins and the production thereof | |
| GB1505899A (en) | 3,4-dihydrocarbostyril derivatives | |
| GB1458340A (en) | Ixo | |
| GB1508814A (en) | Antibiotic derivatives of xk-62-2 and method of production thereof | |
| GB1434572A (en) | Gentamicin derivatives | |
| GB1305725A (enrdf_load_stackoverflow) | ||
| IE41106L (en) | Pharmaceutical compositions containing benzylamines | |
| GB1299566A (en) | Bis-basic ethers of 2,6- and 2,7-dihydroxyanthraquinones | |
| GB1505852A (en) | Deoxykanamycin b derivatives | |
| IE31997L (en) | Arylalkyloxy-benzamides | |
| GB1173562A (en) | Chloramphenicol Ester Salts, the Preparation therof and Compositions Containing them | |
| GB1322069A (en) | Aminoalkanoylaminocyclohexane derivatives | |
| GB1499041A (en) | Derivatives of kanamycin | |
| GB1273399A (en) | Novel formamido-cycloalkane derivatives | |
| GB1265086A (enrdf_load_stackoverflow) | ||
| GB1269404A (en) | 0-substituted-2,5-diphenylpyrroles | |
| GB1339010A (en) | Tetrazolyl-anthraquinone derivatives |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |