GB1452458A - Method and apparatus for studying particles having widely dirr - Google Patents

Method and apparatus for studying particles having widely dirr

Info

Publication number
GB1452458A
GB1452458A GB493875A GB493875A GB1452458A GB 1452458 A GB1452458 A GB 1452458A GB 493875 A GB493875 A GB 493875A GB 493875 A GB493875 A GB 493875A GB 1452458 A GB1452458 A GB 1452458A
Authority
GB
United Kingdom
Prior art keywords
aperture
small aperture
particle
threshold
pulses
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB493875A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Coulter Electronics Ltd
Coulter Electronics Inc
Original Assignee
Coulter Electronics Ltd
Coulter Electronics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coulter Electronics Ltd, Coulter Electronics Inc filed Critical Coulter Electronics Ltd
Publication of GB1452458A publication Critical patent/GB1452458A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1031—Investigating individual particles by measuring electrical or magnetic effects
    • G01N15/12—Investigating individual particles by measuring electrical or magnetic effects by observing changes in resistance or impedance across apertures when traversed by individual particles, e.g. by using the Coulter principle
    • G01N15/134—Devices using two or more apertures

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

1452458 Particle analysis COULTER ELECTRONICS Ltd 5 Feb 1975 [6 Feb 1974] 4938/75 Heading G1N To avoid blocking the aperture when analyzing suspensions containing a range of particle sizes a large aperture 34 (e.g. 250 cc) is arranged beside a small aperture 32 (e.g. 50Á) at the top of the container. Measurements with the small aperture are not started until the pulse rate from the aperture 34 indicates that the larger particles are sinking from the upper layer of the suspension. An aperture 36 at a lower level in the container enables larger particles to be measured at the same time. Block Diagram Circuit Fig. 2 is for a large part self-explanatory and provides conventional delays to allow steady flow before measurement, and volume detectors to stop measurement. Control of the start of flow through the small aperture 32 is determined by pulses from the larger parallel aperture 34 which are applied to a threshold circuit 78 which is set for a particle (pulse) size which would block the small aperture. These larger pulses passing the threshold 78 discharge an integrator 80 (integrating an input voltage from battery). When there are insufficient large particle pulses to discharge the integrator its output rises to the level of threshold 86 to initiate flow through the small aperture 32.
GB493875A 1974-02-06 1975-02-05 Method and apparatus for studying particles having widely dirr Expired GB1452458A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US439875A US3882385A (en) 1974-02-06 1974-02-06 Method and apparatus for studying particles having widely different sizes

Publications (1)

Publication Number Publication Date
GB1452458A true GB1452458A (en) 1976-10-13

Family

ID=23746498

Family Applications (1)

Application Number Title Priority Date Filing Date
GB493875A Expired GB1452458A (en) 1974-02-06 1975-02-05 Method and apparatus for studying particles having widely dirr

Country Status (7)

Country Link
US (1) US3882385A (en)
JP (1) JPS50110388A (en)
CA (1) CA1013433A (en)
DE (1) DE2504755A1 (en)
FR (1) FR2260099B1 (en)
GB (1) GB1452458A (en)
SE (1) SE7501255L (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578771A (en) * 1993-02-12 1996-11-26 Outokumpu Mintec Oy Method for measuring particle size distribution

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU173092B (en) * 1976-02-24 1979-02-28 Medicor Muevek Circuit arrangement for measuring the quantity of erythrocytes, the average volume of cells,the value of haematocrit and other blood parameters
US4078211A (en) * 1976-09-29 1978-03-07 Coulter Electronics, Inc. Method and apparatus for balancing particle detecting signals generated in a particle study device having multiple apertures
US4157499A (en) * 1977-09-15 1979-06-05 Becton, Dickinson And Company Blood cell counter having dual testing heads
US4307339A (en) * 1979-12-10 1981-12-22 Ferrell Michael W Particle counter
US4450435A (en) * 1981-11-30 1984-05-22 Bobby Dencil James Analog debris alarm
GB8606299D0 (en) * 1986-03-14 1986-04-23 Holley J E F Scanner
EP0580525A1 (en) * 1992-07-13 1994-01-26 Eastman Kodak Company Particle size probe for silver halide emulsion
US5610027A (en) * 1992-10-30 1997-03-11 Micro-Med, Inc. Microphoto lysis-anlaysis process to measure cell characteristics
US5955295A (en) * 1992-10-30 1999-09-21 Micro-Med, Inc. Micro lysis-analysis process to measure cell characteristics and diagnose diseases
US5532139A (en) * 1992-10-30 1996-07-02 Micro-Med, Inc. Micro lysis-analysis process to measure cell characteristics and diagnose diseases
AU2003279801A1 (en) * 2002-10-02 2004-04-23 Airadvice, Inc. Method and apparatus for particle sizing
US8146407B2 (en) * 2008-06-20 2012-04-03 Beckman Coulter, Inc. Particle counter with electronic detection of aperture blockage

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3444464A (en) * 1965-11-26 1969-05-13 Coulter Electronics Multiple aperture fittings for particle analyzing apparatus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578771A (en) * 1993-02-12 1996-11-26 Outokumpu Mintec Oy Method for measuring particle size distribution

Also Published As

Publication number Publication date
US3882385A (en) 1975-05-06
JPS50110388A (en) 1975-08-30
DE2504755A1 (en) 1975-08-07
CA1013433A (en) 1977-07-05
SE7501255L (en) 1975-08-07
FR2260099B1 (en) 1977-11-18
FR2260099A1 (en) 1975-08-29

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee