GB1450886A - D-homsteroids - Google Patents
D-homsteroidsInfo
- Publication number
- GB1450886A GB1450886A GB764376A GB764376A GB1450886A GB 1450886 A GB1450886 A GB 1450886A GB 764376 A GB764376 A GB 764376A GB 764376 A GB764376 A GB 764376A GB 1450886 A GB1450886 A GB 1450886A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydroxy
- homo
- diene
- methoxy
- carboxylic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
- C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
Abstract
1450886 D-homosteroids F HOFFMANNLA ROCHE & CO AG 25 Sept 1974 [26 Sept 1973] 7643/76 Divided out of 1450884 Heading C2U The invention comprises 3-oxo-17a#-hydroxy- D - homo - 19 - nor - 17aα - pregn - 5(10) - ene- 21-carboxylic acid γ-lactone (Ia) and its 5(10), 16- diene analogue (Ib). Compound Ia is prepared from D-homoestrone methyl ether (II) by the sequence II#3- methoxy - 17a# - hydroxy - D - homoestra- 2,5(10) - diene#3 - methoxy - D - homoestra- 2,5(10) - dien - 17a - one#3 - methoxy - 17aα- ethynyl - 17a# - hydroxy - D - homoestra - 2,5(10)- diene (III)# the Li salt of III#3-methoxy- 17a# - hydroxy - D - homo - 19 - nor - 17aα- pregna - 2,5(10) - dien - 20 - yne - 21 - carboxylic acid#3 - oxo - 17a# - hydroxy - D - homo - 19- nor - 17aα - pregna - 5(10),20 - diene - 21- carboxylic acid γ-lactone#Ia. In a variant, Ia is obtained from III via 17aα-ethynyl-17a#- hydroxy - D - homoestr - 5(10) - en - 3 - one and 3#,17a# - dihydroxy - D - homo - 19 - nor - 17aα- pregn-5(10)-ene-21-carboxylic acid γ-lactone. Compound Ib is prepared analogously from 16-dehydro-D-homoestrone methyl ether, itself prepared from II by bromination and dehydrobromination.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1376373A CH601352A5 (en) | 1973-09-26 | 1973-09-26 | |
GB4170674A GB1450884A (en) | 1973-09-26 | 1974-09-25 | D-homosteroid lactones |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1450886A true GB1450886A (en) | 1976-09-29 |
Family
ID=25713021
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB764376A Expired GB1450886A (en) | 1973-09-26 | 1974-09-25 | D-homsteroids |
GB764276A Expired GB1450885A (en) | 1973-09-26 | 1974-09-25 | D-homosteroids |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB764276A Expired GB1450885A (en) | 1973-09-26 | 1974-09-25 | D-homosteroids |
Country Status (1)
Country | Link |
---|---|
GB (2) | GB1450886A (en) |
-
1974
- 1974-09-25 GB GB764376A patent/GB1450886A/en not_active Expired
- 1974-09-25 GB GB764276A patent/GB1450885A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
GB1450885A (en) | 1976-09-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |