GB1443620A - Preparation of cyclisates - Google Patents

Preparation of cyclisates

Info

Publication number
GB1443620A
GB1443620A GB3769374A GB3769374A GB1443620A GB 1443620 A GB1443620 A GB 1443620A GB 3769374 A GB3769374 A GB 3769374A GB 3769374 A GB3769374 A GB 3769374A GB 1443620 A GB1443620 A GB 1443620A
Authority
GB
United Kingdom
Prior art keywords
ring
solvent
heated
temperature
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3769374A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dynamit Nobel AG
Original Assignee
Dynamit Nobel AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2343462A external-priority patent/DE2343462C2/en
Application filed by Dynamit Nobel AG filed Critical Dynamit Nobel AG
Publication of GB1443620A publication Critical patent/GB1443620A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Thin Film Transistor (AREA)
  • Junction Field-Effect Transistors (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)

Abstract

1443620 Naphthyridine and quinoline derivatives by ring-closure DYNAMIT-NOBEL AG 28 Aug 1974 [29 Aug 1973] 37693/74 Heading C2C A process for the preparation of a cyclisate comprises effecting, in an organic solvent, a ring-closure reaction of a compound capable of undergoing such a reaction when heated in the solvent, wherein the compound, either in the form of a melt or in the form of a solution in an organic solvent, is brought to the temperature required for the ring-closure reaction by being mixed with a quantity of pre-heated organic solvent, the quantity and temperature of the pre-heated solvent being such that the resulting reaction mixture has the temperature required for the ring-closure reaction. The ring-closure reaction is preferably effected at a temperature of from 200‹ to 360‹ C. with the solvent being pre-heated to a temperature of from 240‹ to 360‹ C. Suitable solvents include diphenylbenzene, dibenzylbenzene, ditolyl, diphenylethane, triphenylmethane, tetraphenylmethane, benzophenone, and terephthalic acid dimethyl ester. Following the ring-closure reaction, the reaction mixture is suitably quenched by passage through a heat exchanger or by the introduction into a low-boiling solvent. Examples describe the preparation of 4-hydroxy-3- carbalkoxy - naphthyridines and quinolines, which may be further substituted, from the corresponding pyridyl- and phenyl-aminomethylene malonic acid ester, and compounds having the general formula wherein R 1 is N or CH, R 2 and R 5 are alkyl groups, R 3 and R 4 are alkyl or alkoxy groups or halogen atoms or together represent an group, and R 6 is hydrogen or alkyl from a compound of the formula
GB3769374A 1973-08-29 1974-08-28 Preparation of cyclisates Expired GB1443620A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2343462A DE2343462C2 (en) 1973-08-29 1973-08-29 Process for the preparation of cyclic compounds from an ester by ring closure reactions

Publications (1)

Publication Number Publication Date
GB1443620A true GB1443620A (en) 1976-07-21

Family

ID=5890990

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3769374A Expired GB1443620A (en) 1973-08-29 1974-08-28 Preparation of cyclisates

Country Status (13)

Country Link
JP (1) JPS5050380A (en)
BE (1) BE819195A (en)
CA (1) CA1050026A (en)
CH (1) CH599074A5 (en)
DK (1) DK139968C (en)
ES (1) ES429588A1 (en)
FI (1) FI251874A (en)
FR (1) FR2245584B1 (en)
GB (1) GB1443620A (en)
HU (1) HU169039B (en)
IT (1) IT1021613B (en)
NL (1) NL7411274A (en)
SE (1) SE402273B (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2504875A (en) * 1945-06-04 1950-04-18 Us Sec War Method for producing 4-hydroxyquinolines

Also Published As

Publication number Publication date
SE402273B (en) 1978-06-26
DK139968C (en) 1979-11-05
FR2245584A1 (en) 1975-04-25
SE7410896L (en) 1975-03-03
CA1050026A (en) 1979-03-06
DK457874A (en) 1975-04-28
DK139968B (en) 1979-05-28
FR2245584B1 (en) 1978-02-17
HU169039B (en) 1976-09-28
ES429588A1 (en) 1976-09-16
JPS5050380A (en) 1975-05-06
NL7411274A (en) 1975-03-04
FI251874A (en) 1975-03-01
CH599074A5 (en) 1978-05-12
IT1021613B (en) 1978-02-20
BE819195A (en) 1974-12-16

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee