GB1435792A - Oxime ethers of norethindrone - Google Patents
Oxime ethers of norethindroneInfo
- Publication number
- GB1435792A GB1435792A GB4461473A GB4461473A GB1435792A GB 1435792 A GB1435792 A GB 1435792A GB 4461473 A GB4461473 A GB 4461473A GB 4461473 A GB4461473 A GB 4461473A GB 1435792 A GB1435792 A GB 1435792A
- Authority
- GB
- United Kingdom
- Prior art keywords
- norethindrone
- cyclopentyloxyamine
- sept
- ethyl
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940053934 norethindrone Drugs 0.000 title abstract 4
- -1 Oxime ethers Chemical class 0.000 title abstract 3
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000006545 (C1-C9) alkyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000001833 anti-estrogenic effect Effects 0.000 abstract 1
- BRTFVKHPEHKBQF-UHFFFAOYSA-N bromocyclopentane Chemical compound BrC1CCCC1 BRTFVKHPEHKBQF-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 abstract 1
- 239000000328 estrogen antagonist Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- MNKASCBJTCNLBN-UHFFFAOYSA-N ethyl n-cyclopentyloxycarbamate Chemical compound CCOC(=O)NOC1CCCC1 MNKASCBJTCNLBN-UHFFFAOYSA-N 0.000 abstract 1
- 238000001640 fractional crystallisation Methods 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- HWWCBAWGNJYHPP-UHFFFAOYSA-N o-cyclopentylhydroxylamine Chemical compound NOC1CCCC1 HWWCBAWGNJYHPP-UHFFFAOYSA-N 0.000 abstract 1
- KBYLNXKSGMLDDM-UHFFFAOYSA-N o-cyclopentylhydroxylamine;hydrochloride Chemical compound Cl.NOC1CCCC1 KBYLNXKSGMLDDM-UHFFFAOYSA-N 0.000 abstract 1
- 229940127234 oral contraceptive Drugs 0.000 abstract 1
- 239000003539 oral contraceptive agent Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- NYBWUHOMYZZKOR-UHFFFAOYSA-N tes-adt Chemical class C1=C2C(C#C[Si](CC)(CC)CC)=C(C=C3C(SC=C3)=C3)C3=C(C#C[Si](CC)(CC)CC)C2=CC2=C1SC=C2 NYBWUHOMYZZKOR-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2967772 | 1972-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1435792A true GB1435792A (en) | 1976-05-12 |
Family
ID=11228233
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4461473A Expired GB1435792A (en) | 1972-09-26 | 1973-09-24 | Oxime ethers of norethindrone |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3912768A (https=) |
| JP (1) | JPS547790B2 (https=) |
| CA (1) | CA1015743A (https=) |
| DE (1) | DE2348197C3 (https=) |
| DK (1) | DK137365B (https=) |
| FR (1) | FR2200010B1 (https=) |
| GB (1) | GB1435792A (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4027019A (en) * | 1975-07-24 | 1977-05-31 | Ortho Pharmaceutical Corporation | 3-Oximes of D-17α-ethynyl-19-nortestosterone esters and method |
| AU3257993A (en) * | 1991-12-22 | 1993-07-28 | Schering Aktiengesellschaft | 3-methylsulphonylhydrazono and 3-oxyimino steroids, a method of preparing them, pharmaceutical preparations containing them and their use in the preparation of drugs |
| US7576226B2 (en) * | 2003-06-30 | 2009-08-18 | Richter Gedeon Vegyeszeti Gyar Rt. | Process of making isomers of norelgestromin and methods using the same |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3299107A (en) * | 1965-02-12 | 1967-01-17 | Searle & Co | 17-(unsaturated hydrocarbon-substituted)-3-hydroxyimino-5alpha-androstan-17beta-ols,alkyl and acyl derivatives thereof |
| US3780073A (en) * | 1966-07-06 | 1973-12-18 | Ortho Pharma Corp | 3-oximes of 19-nortestosterone esters |
| US3507888A (en) * | 1966-08-30 | 1970-04-21 | Searle & Co | Process and intermediates for manufacture of 17-oxygenated estr-4-en-3-ones |
| BE718271A (https=) * | 1968-07-18 | 1969-01-20 | ||
| US3629304A (en) * | 1969-06-16 | 1971-12-21 | Searle & Co | 17alpha-alkynyl - 11beta 13beta - dialkylgona-1 3 5 (10)-triene - 3 17beta-diol 3-cycloalkyl ethers compositions and method |
| CA887049A (en) * | 1969-11-05 | 1971-11-30 | Kruger Gunther | Estradiol 3-propargyl ether 17-trichloroacetate |
| US3862193A (en) * | 1970-12-02 | 1975-01-21 | Ortho Pharma Corp | O-(nitroaryl) oximes of 3-keto steroids |
-
1973
- 1973-09-17 US US398114A patent/US3912768A/en not_active Expired - Lifetime
- 1973-09-20 CA CA181,505A patent/CA1015743A/en not_active Expired
- 1973-09-24 GB GB4461473A patent/GB1435792A/en not_active Expired
- 1973-09-25 DK DK522873AA patent/DK137365B/da not_active IP Right Cessation
- 1973-09-25 FR FR7334395A patent/FR2200010B1/fr not_active Expired
- 1973-09-25 DE DE2348197A patent/DE2348197C3/de not_active Expired
- 1973-09-26 JP JP10832073A patent/JPS547790B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS547790B2 (https=) | 1979-04-10 |
| FR2200010B1 (https=) | 1977-09-09 |
| DE2348197C3 (de) | 1979-08-30 |
| CA1015743A (en) | 1977-08-16 |
| JPS49132061A (https=) | 1974-12-18 |
| DK137365B (da) | 1978-02-27 |
| DE2348197B2 (de) | 1979-01-04 |
| FR2200010A1 (https=) | 1974-04-19 |
| AU6068273A (en) | 1975-03-27 |
| DE2348197A1 (de) | 1974-03-28 |
| DK137365C (https=) | 1978-07-24 |
| US3912768A (en) | 1975-10-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |