GB1434099A - 1,3-diazocine derivatives - Google Patents

1,3-diazocine derivatives

Info

Publication number
GB1434099A
GB1434099A GB2607973A GB2607973A GB1434099A GB 1434099 A GB1434099 A GB 1434099A GB 2607973 A GB2607973 A GB 2607973A GB 2607973 A GB2607973 A GB 2607973A GB 1434099 A GB1434099 A GB 1434099A
Authority
GB
United Kingdom
Prior art keywords
hydrogen atom
alkyl
general formula
hydroxyl group
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2607973A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
John Wyeth and Brother Ltd
Original Assignee
John Wyeth and Brother Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by John Wyeth and Brother Ltd filed Critical John Wyeth and Brother Ltd
Priority to GB2607973A priority Critical patent/GB1434099A/en
Priority to US05/582,038 priority patent/US3996207A/en
Publication of GB1434099A publication Critical patent/GB1434099A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
    • C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

1434099 Hexahydro-1,3-diazocines JOHN WYETH & BRO Ltd 17 May 1974 [31 May 1973] 26079/73 Addition to 1403732 Heading C2C Novel hexahydro-1,3-diazocines of the general formula wherein Ph is a phenyl group optionally substituted by one or more hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, halo-C 1-6 alkyl, halogen, amino or mono- or di-C 1-6 alkylamino radical, R is a hydrogen atom or a phenyl group optionally substituted by one or more hydroxyl, C 1-6 alkyl, C 1-6 alkoxy, halo-C 1-6 alkyl, halogen, amino or mono- or di-C 1-6 alkylamino radical and R<SP>1</SP> is a hydroxyl group or R and R<SP>1</SP> together form an oxo group and each of R<SP>2</SP> and R<SP>3</SP> is a hydrogen atom or C 1-6 alkyl group, and acid addition salts thereof are prepared (a) when R and R<SP>1</SP> together form an oxo group, by oxidizing the corresponding compound in which R is a hydrogen atom and R<SP>1</SP> is a hydroxyl group; (6) when R<SP>1</SP> is a hydroxyl group and R is other than a hydrogen atom, by reacting the product of (a) with a suitable organo-metallic compound; (c) when R<SP>1</SP> and R are as in (b), by oxidizing the corresponding compound in which R<SP>1</SP> is a hydrogen atom, and (d) when R is a hydrogen atom and R<SP>1</SP> is a hydroxyl group, by reacting a diamine of the general formula with an imino ether of the general formula wherein OR<SP>5</SP> is an etherified hydroxyl group, or an amidine of the general formula followed optionally by salification of the product. Pharmaceutical compositions having hypoglycaemic activity comprise, as active ingredient, a hexahydro-1,3-diazocine of the first general formula above, wherein R<SP>1</SP> is a hydroxyl group and R is other than a hydrogen atom, or a pharmaceutically acceptable acid addition salt thereof, in association with a pharmaceutically acceptable carrier.
GB2607973A 1971-01-11 1973-05-31 1,3-diazocine derivatives Expired GB1434099A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GB2607973A GB1434099A (en) 1973-05-31 1973-05-31 1,3-diazocine derivatives
US05/582,038 US3996207A (en) 1971-01-11 1975-05-29 Derivatives of tetrahydro-1H-1,3-diazepine and hexahydro-1,3-diazocine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2607973A GB1434099A (en) 1973-05-31 1973-05-31 1,3-diazocine derivatives

Publications (1)

Publication Number Publication Date
GB1434099A true GB1434099A (en) 1976-04-28

Family

ID=10238023

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2607973A Expired GB1434099A (en) 1971-01-11 1973-05-31 1,3-diazocine derivatives

Country Status (1)

Country Link
GB (1) GB1434099A (en)

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee