GB1433013A - - Google Patents

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Publication number
GB1433013A
GB1433013A GB2747173A GB2747173A GB1433013A GB 1433013 A GB1433013 A GB 1433013A GB 2747173 A GB2747173 A GB 2747173A GB 2747173 A GB2747173 A GB 2747173A GB 1433013 A GB1433013 A GB 1433013A
Authority
GB
United Kingdom
Prior art keywords
diphenyl
alkyl
formula
trans
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2747173A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to GB2747173A priority Critical patent/GB1433013A/en
Publication of GB1433013A publication Critical patent/GB1433013A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1433013 Substituted trans - 3,4 - (diphenyl)- chromans RIKER LABORATORIES Inc 8 June 1973 27471/73 Heading C2C A process for the production of a substituted trans-3,4-(diphenyl)-chroman of the formula wherein R is (C 1 -C 6 ) alkyl; R<SP>3</SP> is (C 1 -C 6 ) alkyl or alkoxy, halogen or trifluoromethyl; Alk is (C 2 -C 6 ) alkylene; R<SP>1</SP> and R<SP>3</SP> are hydrogen or (C 1 -C 6 ) alkyl or, together with the nitrogen atom to which they are attached, form a pyrrolidino morpholino, piperidino, piperazino, 4-alkylpiperazino or 4-phenylpiperazino radical, comprises catalytically rearranging the corresponding cis compound by treatment with an organo-lithium or alkali metal alkoxide catalyst. The cis isomer is suitably prepared by catalytically hydrogenating a substituted 3,4-(diphenyl) chromene of the formula and reacting the chroman so formed with a compound of the formula: X.Alk.NR<SP>1</SP>R<SP>2</SP>, wherein X is halogen. The process is also suitable for converting a cis, trans isomer mixture into the trans isomer.
GB2747173A 1973-06-08 1973-06-08 Expired GB1433013A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2747173A GB1433013A (en) 1973-06-08 1973-06-08

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2747173A GB1433013A (en) 1973-06-08 1973-06-08

Publications (1)

Publication Number Publication Date
GB1433013A true GB1433013A (en) 1976-04-22

Family

ID=10260138

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2747173A Expired GB1433013A (en) 1973-06-08 1973-06-08

Country Status (1)

Country Link
GB (1) GB1433013A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7601855B2 (en) 2004-09-21 2009-10-13 Novogen Research Pty Ltd Substituted chroman derivatives, medicaments and use in therapy
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
US9663484B2 (en) 2010-11-01 2017-05-30 Mei Pharma, Inc. Isoflavonoid compounds and methods for the treatment of cancer
US10980774B2 (en) 2015-02-02 2021-04-20 Mei Pharma, Inc. Combination therapies

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9381186B2 (en) 2004-09-21 2016-07-05 Mei Pharma, Inc. Substituted chroman derivatives, medicaments and use in therapy
US8084628B2 (en) 2004-09-21 2011-12-27 Marshall Edwards, Inc. Substituted chroman derivatives, medicaments and use in therapy
US7601855B2 (en) 2004-09-21 2009-10-13 Novogen Research Pty Ltd Substituted chroman derivatives, medicaments and use in therapy
US8461361B2 (en) 2004-09-21 2013-06-11 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
US8697891B2 (en) 2004-09-21 2014-04-15 Marshall Edwards, Inc. Substituted chroman derivatives, medicaments and use in therapy
US8957109B2 (en) 2004-09-21 2015-02-17 Mei Pharma, Inc. Chroman derivatives, medicaments and use in therapy
US9138478B2 (en) 2004-09-21 2015-09-22 Mei Pharma, Inc. Substituted chroman derivatives, medicaments and use in therapy
US9198895B2 (en) 2004-09-21 2015-12-01 Mei Pharma, Inc. Chroman derivatives, medicaments and use in therapy
US8080675B2 (en) 2004-09-21 2011-12-20 Marshall Edwards, Inc. Chroman derivatives, medicaments and use in therapy
US11723893B2 (en) 2010-11-01 2023-08-15 Mei Pharma, Inc. Isoflavonoid compositions and methods for the treatment of cancer
US9708283B2 (en) 2010-11-01 2017-07-18 Mei Pharma, Inc. Isoflavonoid compositions and methods for the treatment of cancer
US9981936B2 (en) 2010-11-01 2018-05-29 Mei Pharma, Inc. Isoflavonoid compositions and methods for the treatment of cancer
US10105346B2 (en) 2010-11-01 2018-10-23 Mei Pharma, Inc. Isoflavonoid compounds and methods for the treatment of cancer
US10369132B2 (en) 2010-11-01 2019-08-06 Mei Pharma, Inc. Isoflavonoid compositions and methods for the treatment of cancer
US10973799B2 (en) 2010-11-01 2021-04-13 Mei Pharma, Inc. Isoflavonoid compositions and methods for the treatment of cancer
US11583514B2 (en) 2010-11-01 2023-02-21 Mei Pharma, Inc. Isoflavonoid compounds and methods for the treatment of cancer
US9663484B2 (en) 2010-11-01 2017-05-30 Mei Pharma, Inc. Isoflavonoid compounds and methods for the treatment of cancer
US10980774B2 (en) 2015-02-02 2021-04-20 Mei Pharma, Inc. Combination therapies

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee