GB1432249A - Peptide enzyme inhibitor - Google Patents

Peptide enzyme inhibitor

Info

Publication number
GB1432249A
GB1432249A GB2318573A GB2318573A GB1432249A GB 1432249 A GB1432249 A GB 1432249A GB 2318573 A GB2318573 A GB 2318573A GB 2318573 A GB2318573 A GB 2318573A GB 1432249 A GB1432249 A GB 1432249A
Authority
GB
United Kingdom
Prior art keywords
pro
tyr
obu
bzl
gln
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2318573A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US00258714A external-priority patent/US3832337A/en
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB1432249A publication Critical patent/GB1432249A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1432249 Octa- and nonapeptides E R SQUIBB & SONS Inc 15 May 1973 [1 June 1972] 23185/73 Heading C3H The invention comprises octapeptides of the formula wherein N is cyclobutylcarbonyl, cyclopropanecarbonyl, or cyclohexylcarbonyl, O is Trp, Tyr, Tyr(Bzl), Pne, Gly, Leu or D-Trp, and X is Gln or Glu, nonapeptides of the formula wherein O<SP>1</SP> is Tyr, Tyr(Bzl), Phe, Gly, Leu or D-Trp, and the nonapeptide of the formula and salts thereof. The peptides are obtained by standard procedures. The following intermediate peptides are also prepared H-Tyr-Pro-OH.trifluoroacetate, HPyr-Tyr-Pro-OH, Z-Pro-Pro-OBu<SP>t</SP>, wherein Z is benzyloxycarbonyl, Z-Ile-Pro-Pro-OBu<SP>t</SP>, Z-Gln-Ile-Pro-Pro-OBu<SP>t</SP>, Z-Pro-Gln-Ile-Pro- Pro-OBu<SP>t</SP>, Z-Arg(NO 2 )-Pro-Gln-Ile-Pro-Pro- OBu<SP>t</SP>, H-Arg-Pro-Gln-Ile-Pro-Pro-OH.2HCl, Z-Phe-Pro-OBu<SP>t</SP>, Cpc-Phe-Pro-OH, wherein Cpc is cyclopropylcarbonyl, H-Trp-Pro-OH. trifluoroacetate, Cpc-Trp-Pro-OH, H-Tyr(Bzl)- Pro-OH.trifluoroacetate, H-Pyr-Tyr(Bzl)-Pro- OH, Cpc-Tyr(Bzl)-Pro-OH. Certain of the peptides absorb ultraviolet radiation and may be used to prepare suntan lotions or creams.
GB2318573A 1972-06-01 1973-05-15 Peptide enzyme inhibitor Expired GB1432249A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US00258714A US3832337A (en) 1970-07-28 1972-06-01 Peptide enzyme inhibitors

Publications (1)

Publication Number Publication Date
GB1432249A true GB1432249A (en) 1976-04-14

Family

ID=22981808

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2318573A Expired GB1432249A (en) 1972-06-01 1973-05-15 Peptide enzyme inhibitor

Country Status (3)

Country Link
CH (1) CH568964A5 (en)
DE (1) DE2328093A1 (en)
GB (1) GB1432249A (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2921216A1 (en) * 1979-05-25 1980-12-04 Teschemacher Hansjoerg PHARMACOLOGICALLY ACTIVE PEPTIDES
IT1164225B (en) * 1983-05-13 1987-04-08 Anic Spa INVERTED ANALOGS OF PENTAPEPTIDE ENHANCING BRADICHINA BPP5A AND METHODS FOR THEIR PREPARATION

Also Published As

Publication number Publication date
DE2328093A1 (en) 1973-12-20
CH568964A5 (en) 1975-11-14

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years

Effective date: 19930514