GB1427189A - Substituted 2-hydrazonomethyl-3-hydroxy-4-azy-2,4-pentadienenitri les a methof for producint them and medicaments containing them - Google Patents
Substituted 2-hydrazonomethyl-3-hydroxy-4-azy-2,4-pentadienenitri les a methof for producint them and medicaments containing themInfo
- Publication number
- GB1427189A GB1427189A GB4166773A GB4166773A GB1427189A GB 1427189 A GB1427189 A GB 1427189A GB 4166773 A GB4166773 A GB 4166773A GB 4166773 A GB4166773 A GB 4166773A GB 1427189 A GB1427189 A GB 1427189A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- hydrogen
- group
- replaced
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003814 drug Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 229910052760 oxygen Inorganic materials 0.000 abstract 7
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 4
- 229910052717 sulfur Inorganic materials 0.000 abstract 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000304 alkynyl group Chemical group 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 201000005569 Gout Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- -1 dimethylamino, pyrrolidino Chemical group 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| LU66038 | 1972-09-08 | ||
| LU66039 | 1972-09-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1427189A true GB1427189A (en) | 1976-03-10 |
Family
ID=26640115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4166773A Expired GB1427189A (en) | 1972-09-08 | 1973-09-05 | Substituted 2-hydrazonomethyl-3-hydroxy-4-azy-2,4-pentadienenitri les a methof for producint them and medicaments containing them |
Country Status (9)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6191136B1 (en) | 1997-11-07 | 2001-02-20 | Johns Hopkins University | Methods for treatment of disorders of cardiac contractility |
-
1973
- 1973-09-05 CH CH1271873A patent/CH599131A5/xx not_active IP Right Cessation
- 1973-09-05 GB GB4166773A patent/GB1427189A/en not_active Expired
- 1973-09-05 DE DE19732344738 patent/DE2344738A1/de active Pending
- 1973-09-06 IE IE1584/73A patent/IE38219B1/xx unknown
- 1973-09-06 CA CA180,459A patent/CA1020947A/en not_active Expired
- 1973-09-07 FR FR7332264A patent/FR2198748B1/fr not_active Expired
- 1973-09-07 JP JP48101038A patent/JPS4966632A/ja active Pending
- 1973-09-07 NL NL7312333A patent/NL7312333A/xx not_active Application Discontinuation
-
1976
- 1976-10-19 SE SE7611589A patent/SE7611589L/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6191136B1 (en) | 1997-11-07 | 2001-02-20 | Johns Hopkins University | Methods for treatment of disorders of cardiac contractility |
| US6569862B1 (en) | 1997-11-07 | 2003-05-27 | Johns Hopkins University | Methods for treatment of disorders of cardiac contractility |
Also Published As
| Publication number | Publication date |
|---|---|
| CH599131A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1978-05-12 |
| SE7611589L (sv) | 1976-10-19 |
| FR2198748A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-04-05 |
| CA1020947A (en) | 1977-11-15 |
| FR2198748B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1977-07-15 |
| JPS4966632A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-06-27 |
| IE38219L (en) | 1974-03-08 |
| IE38219B1 (en) | 1978-01-18 |
| DE2344738A1 (de) | 1974-04-04 |
| NL7312333A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |