GB1426386A - Process for preparing 2- 6-methoxy-2-naphthyl-propionic acid - Google Patents

Process for preparing 2- 6-methoxy-2-naphthyl-propionic acid

Info

Publication number
GB1426386A
GB1426386A GB2073473A GB2073473A GB1426386A GB 1426386 A GB1426386 A GB 1426386A GB 2073473 A GB2073473 A GB 2073473A GB 2073473 A GB2073473 A GB 2073473A GB 1426386 A GB1426386 A GB 1426386A
Authority
GB
United Kingdom
Prior art keywords
methoxy
naphthyl
propionic acid
preparing
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2073473A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Palo Alto LLC
Original Assignee
Roche Palo Alto LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Publication of GB1426386A publication Critical patent/GB1426386A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/28—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of CHx-moieties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1426386 2 - (6 - Methoxy - 2 - naphthyl) propionic acid SYNTEX CORP 2 May 1973 [11 May 1972] 20734/73 Heading C2C dl - 2 - (6 - Methoxy - 2 - naphthyl) - propionic acid is prepared by treating 6-methoxy-2 (1- propenyl)naphthalene with thallium trinitrate in the presence of a strong acid and a solvent system comprising water and an inert water-miscible ether solvent to give 2-(6-methoxy-2-naphthyl)propanol and oxidizing this to give the desired acid. A dl-mixture thus obtained may be optically resolved if desired. Pharmaceutical compositions having antiinflammatory, analgesic and antipyretic activity, comprise 2-(6-methoxy-2-naphthyl) propionic acid, when prepared by the above method, together with a pharmaceutical carrier.
GB2073473A 1972-05-11 1973-05-02 Process for preparing 2- 6-methoxy-2-naphthyl-propionic acid Expired GB1426386A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US25229072A 1972-05-11 1972-05-11

Publications (1)

Publication Number Publication Date
GB1426386A true GB1426386A (en) 1976-02-25

Family

ID=22955399

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2073473A Expired GB1426386A (en) 1972-05-11 1973-05-02 Process for preparing 2- 6-methoxy-2-naphthyl-propionic acid

Country Status (6)

Country Link
JP (1) JPS4948648A (en)
AU (1) AU5545573A (en)
CA (1) CA1000726A (en)
CH (1) CH581601A5 (en)
ES (1) ES414642A1 (en)
GB (1) GB1426386A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0176142A2 (en) * 1984-09-24 1986-04-02 Nobel Chemicals AB Process for the preparation of aryl alkyl ketones

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0176142A2 (en) * 1984-09-24 1986-04-02 Nobel Chemicals AB Process for the preparation of aryl alkyl ketones
EP0176142A3 (en) * 1984-09-24 1986-09-17 Blaschim S.P.A. Process for the preparation of aryl alkyl ketones

Also Published As

Publication number Publication date
JPS4948648A (en) 1974-05-11
CH581601A5 (en) 1976-11-15
CA1000726A (en) 1976-11-30
ES414642A1 (en) 1976-02-01
AU5545573A (en) 1974-11-14

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees