GB1426353A - 15alpha,16alpha-methylene-5alpha-androstanes - Google Patents
15alpha,16alpha-methylene-5alpha-androstanesInfo
- Publication number
- GB1426353A GB1426353A GB681973A GB681973A GB1426353A GB 1426353 A GB1426353 A GB 1426353A GB 681973 A GB681973 A GB 681973A GB 681973 A GB681973 A GB 681973A GB 1426353 A GB1426353 A GB 1426353A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methylene
- acetoxy
- prepared
- androstan
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003431 steroids Chemical class 0.000 abstract 2
- VXKDKEPCWNJUQD-ORQVUNRVSA-N (1R,2S,7R,10S,11S,16R)-7,11-dimethylpentacyclo[8.8.0.02,7.03,5.011,16]octadecane Chemical class C1C2[C@@H]3[C@](CC21)(C)CC[C@H]1[C@H]3CC[C@H]2CCCC[C@]12C VXKDKEPCWNJUQD-ORQVUNRVSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000003263 anabolic agent Substances 0.000 abstract 1
- 229940124325 anabolic agent Drugs 0.000 abstract 1
- 239000003098 androgen Substances 0.000 abstract 1
- 230000001548 androgenic effect Effects 0.000 abstract 1
- 230000031709 bromination Effects 0.000 abstract 1
- 238000005893 bromination reaction Methods 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000007269 dehydrobromination reaction Methods 0.000 abstract 1
- 238000006356 dehydrogenation reaction Methods 0.000 abstract 1
- NZZFYRREKKOMAT-UHFFFAOYSA-N diiodomethane Chemical compound ICI NZZFYRREKKOMAT-UHFFFAOYSA-N 0.000 abstract 1
- 238000006266 etherification reaction Methods 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000002906 microbiologic effect Effects 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 230000001706 oxygenating effect Effects 0.000 abstract 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000010992 reflux Methods 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722207422 DE2207422A1 (de) | 1972-02-11 | 1972-02-11 | 15alpha, 16alpha-methylen-5alpha-androstane |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1426353A true GB1426353A (en) | 1976-02-25 |
Family
ID=5836212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB681973A Expired GB1426353A (en) | 1972-02-11 | 1973-02-12 | 15alpha,16alpha-methylene-5alpha-androstanes |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4886855A (enExample) |
| AT (1) | AT323345B (enExample) |
| BE (1) | BE795239A (enExample) |
| CH (1) | CH588506A5 (enExample) |
| DE (1) | DE2207422A1 (enExample) |
| DK (1) | DK130988B (enExample) |
| FR (1) | FR2181720B1 (enExample) |
| GB (1) | GB1426353A (enExample) |
| NL (1) | NL7301923A (enExample) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1643035B2 (de) * | 1967-08-11 | 1976-01-15 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | 15beta,16beta-methylen-5alpha -androst-l-ene, verfahren zu deren herstellung sowie diese enthaltende mittel |
-
0
- BE BE795239D patent/BE795239A/xx unknown
-
1972
- 1972-02-11 DE DE19722207422 patent/DE2207422A1/de active Pending
-
1973
- 1973-01-16 DK DK24173A patent/DK130988B/da unknown
- 1973-02-08 AT AT112573A patent/AT323345B/de not_active IP Right Cessation
- 1973-02-09 NL NL7301923A patent/NL7301923A/xx not_active Application Discontinuation
- 1973-02-09 CH CH186273A patent/CH588506A5/xx not_active IP Right Cessation
- 1973-02-09 FR FR7304679A patent/FR2181720B1/fr not_active Expired
- 1973-02-12 GB GB681973A patent/GB1426353A/en not_active Expired
- 1973-02-12 JP JP1735673A patent/JPS4886855A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NL7301923A (enExample) | 1973-08-14 |
| JPS4886855A (enExample) | 1973-11-15 |
| BE795239A (fr) | 1973-08-09 |
| DK130988B (da) | 1975-05-12 |
| AT323345B (de) | 1975-07-10 |
| DE2207422A1 (de) | 1973-08-16 |
| FR2181720B1 (enExample) | 1975-11-21 |
| DK130988C (enExample) | 1975-10-13 |
| FR2181720A1 (enExample) | 1973-12-07 |
| CH588506A5 (enExample) | 1977-06-15 |
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| GB1289020A (enExample) | ||
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |