GB1423585A - Benzotriazine compounds their production and their pharmaceu tical use - Google Patents
Benzotriazine compounds their production and their pharmaceu tical useInfo
- Publication number
- GB1423585A GB1423585A GB5307073A GB5307073A GB1423585A GB 1423585 A GB1423585 A GB 1423585A GB 5307073 A GB5307073 A GB 5307073A GB 5307073 A GB5307073 A GB 5307073A GB 1423585 A GB1423585 A GB 1423585A
- Authority
- GB
- United Kingdom
- Prior art keywords
- coch
- triazine
- optionally substituted
- benzo
- substituted alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
- C07D253/10—Condensed 1,2,4-triazines; Hydrogenated condensed 1,2,4-triazines
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/116—Heterocyclic compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Fodder In General (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1423585 Benzo-1,2,4-triazine-1,4-di-N-oxides BAYER AG 15 Nov 1973 [15 Nov 1972 9 Dec 1972 27 April 1973] 53070/73 Heading C2C Novel benzo-1,2,4-triazine-1,4-di-N-oxides of the general formula wherein each of X<SP>1</SP> and X<SP>2</SP> is a hydrogen or halogen atom or an optionally substituted alkyl or alkoxy group and A is -R, -COR<SP>1</SP>, -COCH 2 COCH 3 or -CONHR<SP>2</SP>, in which R is an optionally substituted alkyl, alkenyl or aralkyl group, R<SP>1</SP> is a hydrogen atom or an optionally substituted alkyl or aryl group and R<SP>2</SP> is an optionally substituted alkyl, cycloalkyl or aryl group, are prepared (a) when A is -R, by alkylating, alkenylating or aralkylating the corresponding compound in which A is a hydrogen atom with RY, wherein Y is a labile radical which is split off during the reaction; (b) when A is -COR<SP>1</SP> or -COCH 2 COCH 3 , by acylating the corresponding compound in which A is a hydrogen atom with ketene, diketene or R<SP>1</SP>COY; and (c) when A is -CONHR<SP>2</SP>, by reacting the corresponding compound in which A is a hydrogen atom with R<SP>2</SP>NCO. The 3 - amino - benzo - 1,2,4 - triazine - 1,4- di-N-oxide starting materials used in (a), (b) and (c) above are prepared by reacting a benzofuroxan of the general formula with disodium cyanamide. Pharmaceutical compositions having antimicrobial and growth-promoting activity comprise, as active ingredient, a benzo-1,2,4-triazine-1,4-di-N-oxide of the first general formula above, together with an appropriate carrier.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2255947A DE2255947A1 (en) | 1972-11-15 | 1972-11-15 | SUBSTITUTED 3-AMINO-BENZO-1,2,4TRIAZINE-DI-N-OXIDES (1,4), METHOD FOR MANUFACTURING AND USING THEM AS ANTIMICROBIAL AGENTS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1423585A true GB1423585A (en) | 1976-02-04 |
Family
ID=5861794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5307073A Expired GB1423585A (en) | 1972-11-15 | 1973-11-15 | Benzotriazine compounds their production and their pharmaceu tical use |
Country Status (19)
| Country | Link |
|---|---|
| JP (2) | JPS4980085A (en) |
| AR (3) | AR200888A1 (en) |
| AT (1) | AT331806B (en) |
| BE (1) | BE807309A (en) |
| BR (1) | BR7308877D0 (en) |
| CH (2) | CH592069A5 (en) |
| CS (1) | CS178138B2 (en) |
| DE (1) | DE2255947A1 (en) |
| DK (1) | DK593374A (en) |
| ES (3) | ES420536A1 (en) |
| FR (1) | FR2206104B1 (en) |
| GB (1) | GB1423585A (en) |
| HU (1) | HU168359B (en) |
| IL (1) | IL43614A (en) |
| LU (1) | LU68790A1 (en) |
| NL (1) | NL7315454A (en) |
| PL (2) | PL87635B1 (en) |
| SU (1) | SU519134A3 (en) |
| ZA (1) | ZA738726B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8372971B2 (en) | 2004-08-25 | 2013-02-12 | Targegen, Inc. | Heterocyclic compounds and methods of use |
| US8481536B2 (en) | 2004-04-08 | 2013-07-09 | Targegen, Inc. | Benzotriazine inhibitors of kinases |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4247691A (en) * | 1977-02-22 | 1981-01-27 | Ciba-Geigy Corporation | 1,2,4-Benzotriazine-1,4-di-N-oxides |
| NZ194612A (en) * | 1979-08-31 | 1982-12-21 | Ici Australia Ltd | Benzotriazine derivatives intermediates and herbicidal compositions |
| US5672702A (en) * | 1995-12-04 | 1997-09-30 | Sanofi | Process for preparing 3 amino 1, 2, 4-benzotriazine dioxide |
| CN115894385A (en) * | 2023-01-09 | 2023-04-04 | 中国科学院长春应用化学研究所 | Tirapazamine derivative and preparation method and application thereof |
-
1972
- 1972-11-15 DE DE2255947A patent/DE2255947A1/en active Pending
-
1973
- 1973-11-12 NL NL7315454A patent/NL7315454A/xx not_active Application Discontinuation
- 1973-11-12 IL IL7343614A patent/IL43614A/en unknown
- 1973-11-13 JP JP48126878A patent/JPS4980085A/ja active Pending
- 1973-11-13 SU SU1967994A patent/SU519134A3/en active
- 1973-11-13 CH CH1594273A patent/CH592069A5/xx not_active IP Right Cessation
- 1973-11-13 CH CH200477A patent/CH592070A5/xx not_active IP Right Cessation
- 1973-11-13 PL PL1973166510A patent/PL87635B1/pl unknown
- 1973-11-13 JP JP48126879A patent/JPS4980218A/ja active Pending
- 1973-11-13 BR BR8877/73A patent/BR7308877D0/en unknown
- 1973-11-13 LU LU68790A patent/LU68790A1/xx unknown
- 1973-11-13 PL PL1973183473A patent/PL99366B1/en unknown
- 1973-11-14 BE BE137737A patent/BE807309A/en unknown
- 1973-11-14 ZA ZA738726A patent/ZA738726B/en unknown
- 1973-11-14 ES ES420536A patent/ES420536A1/en not_active Expired
- 1973-11-14 HU HUBA2995A patent/HU168359B/hu unknown
- 1973-11-14 CS CS7821A patent/CS178138B2/cs unknown
- 1973-11-15 GB GB5307073A patent/GB1423585A/en not_active Expired
- 1973-11-15 AR AR251017A patent/AR200888A1/en active
- 1973-11-15 AT AT961273A patent/AT331806B/en not_active IP Right Cessation
- 1973-11-15 FR FR7340749A patent/FR2206104B1/fr not_active Expired
-
1974
- 1974-11-14 DK DK593374A patent/DK593374A/da unknown
- 1974-11-15 AR AR256554A patent/AR200983A1/en active
- 1974-11-15 AR AR256553A patent/AR203770A1/en active
-
1976
- 1976-01-16 ES ES444359A patent/ES444359A1/en not_active Expired
- 1976-01-16 ES ES444360A patent/ES444360A1/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8481536B2 (en) | 2004-04-08 | 2013-07-09 | Targegen, Inc. | Benzotriazine inhibitors of kinases |
| US8372971B2 (en) | 2004-08-25 | 2013-02-12 | Targegen, Inc. | Heterocyclic compounds and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| AR203770A1 (en) | 1975-10-15 |
| ES444360A1 (en) | 1977-05-16 |
| FR2206104A1 (en) | 1974-06-07 |
| ES444359A1 (en) | 1977-05-16 |
| ZA738726B (en) | 1974-09-25 |
| HU168359B (en) | 1976-04-28 |
| DK593374A (en) | 1975-05-20 |
| LU68790A1 (en) | 1974-01-21 |
| NL7315454A (en) | 1974-05-17 |
| CS178138B2 (en) | 1977-08-31 |
| JPS4980085A (en) | 1974-08-02 |
| ATA961273A (en) | 1975-12-15 |
| JPS4980218A (en) | 1974-08-02 |
| CH592069A5 (en) | 1977-10-14 |
| PL99366B1 (en) | 1978-07-31 |
| CH592070A5 (en) | 1977-10-14 |
| DE2255947A1 (en) | 1974-05-22 |
| IL43614A (en) | 1977-06-30 |
| BR7308877D0 (en) | 1974-09-24 |
| AR200983A1 (en) | 1974-12-27 |
| AT331806B (en) | 1976-08-25 |
| BE807309A (en) | 1974-05-14 |
| IL43614A0 (en) | 1974-03-14 |
| FR2206104B1 (en) | 1977-09-02 |
| ES420536A1 (en) | 1976-07-01 |
| SU519134A3 (en) | 1976-06-25 |
| AR200888A1 (en) | 1974-12-27 |
| AU6242873A (en) | 1975-05-15 |
| PL87635B1 (en) | 1976-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |