GB1422768A - Sustained release tablets containing nicotinic acid and a process for the manufacture thereof - Google Patents
Sustained release tablets containing nicotinic acid and a process for the manufacture thereofInfo
- Publication number
- GB1422768A GB1422768A GB2353574A GB2353574A GB1422768A GB 1422768 A GB1422768 A GB 1422768A GB 2353574 A GB2353574 A GB 2353574A GB 2353574 A GB2353574 A GB 2353574A GB 1422768 A GB1422768 A GB 1422768A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nicotinic acid
- sustained release
- tablets
- sustained
- lubricant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1422768 Sustained-release nicotinic acid tablets F HOFFMANN-LA ROCHE & CO AG 28 May 1974 [29 May 1973] 23535/74 Heading ASB Sustained release tablets containing 75-90 weight % nicotinic acid, 5-15% binder and lubricant and 5-12% sustained release ingredient are prepared by (a) wet granulating nicotinic acid and a water-soluble binder, (b) mixing the granulate with a sustained-release ingredient consisting of mono- and di-glycerides of naturally occurring C 16-18 saturated fatty acids and a pharmaceutical lubricant, (c) tabletting the mixture, (d) heating the tablets to the melting point of the sustained release ingredient and (e) allowing the heated tablets to cool to room temperature. The binder may be a mixture of amylopectin and polyvinylpyrrolidone. The lubricant may be talc and/or magnesium stearate and may include colloidal pyrogenic silica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36444373A | 1973-05-29 | 1973-05-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1422768A true GB1422768A (en) | 1976-01-28 |
Family
ID=23434551
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2353574A Expired GB1422768A (en) | 1973-05-29 | 1974-05-28 | Sustained release tablets containing nicotinic acid and a process for the manufacture thereof |
Country Status (4)
Country | Link |
---|---|
JP (1) | JPS5031022A (en) |
DE (1) | DE2425764A1 (en) |
FR (1) | FR2231365B1 (en) |
GB (1) | GB1422768A (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2163648A (en) * | 1984-08-03 | 1986-03-05 | Nippon Shinyaku Co Ltd | Slow release preparations |
US5853758A (en) * | 1992-01-13 | 1998-12-29 | Pfizer Inc. | Preparation of tablets of increased strength |
EP1688143A2 (en) * | 1992-06-29 | 2006-08-09 | Kos Pharmaceuticals, Inc. | Niacin-containing substained-release tablets and kits |
WO2014179845A1 (en) * | 2013-05-09 | 2014-11-13 | Zeenar Enterprises Pty Ltd | Niacin formulation |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2904310A1 (en) * | 1979-02-05 | 1980-08-07 | Boehringer Mannheim Gmbh | MOLDINGS WITH RETARDED ACTIVE SUBSTANCE RELEASE AND METHOD FOR THE PRODUCTION THEREOF |
JPS5974374U (en) * | 1982-11-11 | 1984-05-19 | セイコーインスツルメンツ株式会社 | Mobile watch dial holding structure |
US4797288A (en) * | 1984-10-05 | 1989-01-10 | Warner-Lambert Company | Novel drug delivery system |
US4804548A (en) * | 1984-10-05 | 1989-02-14 | Warner-Lambert Company | Novel sweetener delivery systems |
US4828857A (en) * | 1984-10-05 | 1989-05-09 | Warner-Lambert Company | Novel sweetener delivery systems |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE1617593A1 (en) * | 1965-10-12 | 1971-04-29 | Leo Pharm Prod Ltd | Method of making tablets or pills |
-
1974
- 1974-05-27 JP JP5890874A patent/JPS5031022A/ja active Pending
- 1974-05-27 FR FR7418230A patent/FR2231365B1/fr not_active Expired
- 1974-05-28 GB GB2353574A patent/GB1422768A/en not_active Expired
- 1974-05-28 DE DE19742425764 patent/DE2425764A1/en active Pending
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2163648A (en) * | 1984-08-03 | 1986-03-05 | Nippon Shinyaku Co Ltd | Slow release preparations |
GB2163648B (en) * | 1984-08-03 | 1989-06-01 | Nippon Shinyaku Co Ltd | Pharmaceutical preparation and a method of making the same |
US5853758A (en) * | 1992-01-13 | 1998-12-29 | Pfizer Inc. | Preparation of tablets of increased strength |
EP1688143A2 (en) * | 1992-06-29 | 2006-08-09 | Kos Pharmaceuticals, Inc. | Niacin-containing substained-release tablets and kits |
EP1688143A3 (en) * | 1992-06-29 | 2009-11-11 | Kos Life Sciences, Inc. | Niacin-containing substained-release tablets and kits |
WO2014179845A1 (en) * | 2013-05-09 | 2014-11-13 | Zeenar Enterprises Pty Ltd | Niacin formulation |
US20160081996A1 (en) * | 2013-05-09 | 2016-03-24 | Zeenar Enterprises Pty Ltd | Niacin Formulation |
EP3016655A4 (en) * | 2013-05-09 | 2017-04-12 | Zeenar Enterprises Pty Ltd | Niacin formulation |
US10105358B2 (en) | 2013-05-09 | 2018-10-23 | Zeenar Enterprises Pty Ltd | Niacin formulation |
US10335403B2 (en) | 2013-05-09 | 2019-07-02 | Zeenar Enterprise Pty Ltd | Niacin formulation |
Also Published As
Publication number | Publication date |
---|---|
DE2425764A1 (en) | 1975-01-02 |
FR2231365A1 (en) | 1974-12-27 |
JPS5031022A (en) | 1975-03-27 |
FR2231365B1 (en) | 1977-11-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |