GB1422768A - Sustained release tablets containing nicotinic acid and a process for the manufacture thereof - Google Patents

Sustained release tablets containing nicotinic acid and a process for the manufacture thereof

Info

Publication number
GB1422768A
GB1422768A GB2353574A GB2353574A GB1422768A GB 1422768 A GB1422768 A GB 1422768A GB 2353574 A GB2353574 A GB 2353574A GB 2353574 A GB2353574 A GB 2353574A GB 1422768 A GB1422768 A GB 1422768A
Authority
GB
United Kingdom
Prior art keywords
nicotinic acid
sustained release
tablets
sustained
lubricant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2353574A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1422768A publication Critical patent/GB1422768A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1422768 Sustained-release nicotinic acid tablets F HOFFMANN-LA ROCHE & CO AG 28 May 1974 [29 May 1973] 23535/74 Heading ASB Sustained release tablets containing 75-90 weight % nicotinic acid, 5-15% binder and lubricant and 5-12% sustained release ingredient are prepared by (a) wet granulating nicotinic acid and a water-soluble binder, (b) mixing the granulate with a sustained-release ingredient consisting of mono- and di-glycerides of naturally occurring C 16-18 saturated fatty acids and a pharmaceutical lubricant, (c) tabletting the mixture, (d) heating the tablets to the melting point of the sustained release ingredient and (e) allowing the heated tablets to cool to room temperature. The binder may be a mixture of amylopectin and polyvinylpyrrolidone. The lubricant may be talc and/or magnesium stearate and may include colloidal pyrogenic silica.
GB2353574A 1973-05-29 1974-05-28 Sustained release tablets containing nicotinic acid and a process for the manufacture thereof Expired GB1422768A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36444373A 1973-05-29 1973-05-29

Publications (1)

Publication Number Publication Date
GB1422768A true GB1422768A (en) 1976-01-28

Family

ID=23434551

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2353574A Expired GB1422768A (en) 1973-05-29 1974-05-28 Sustained release tablets containing nicotinic acid and a process for the manufacture thereof

Country Status (4)

Country Link
JP (1) JPS5031022A (en)
DE (1) DE2425764A1 (en)
FR (1) FR2231365B1 (en)
GB (1) GB1422768A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2163648A (en) * 1984-08-03 1986-03-05 Nippon Shinyaku Co Ltd Slow release preparations
US5853758A (en) * 1992-01-13 1998-12-29 Pfizer Inc. Preparation of tablets of increased strength
EP1688143A2 (en) * 1992-06-29 2006-08-09 Kos Pharmaceuticals, Inc. Niacin-containing substained-release tablets and kits
WO2014179845A1 (en) * 2013-05-09 2014-11-13 Zeenar Enterprises Pty Ltd Niacin formulation

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2904310A1 (en) * 1979-02-05 1980-08-07 Boehringer Mannheim Gmbh MOLDINGS WITH RETARDED ACTIVE SUBSTANCE RELEASE AND METHOD FOR THE PRODUCTION THEREOF
JPS5974374U (en) * 1982-11-11 1984-05-19 セイコーインスツルメンツ株式会社 Mobile watch dial holding structure
US4797288A (en) * 1984-10-05 1989-01-10 Warner-Lambert Company Novel drug delivery system
US4804548A (en) * 1984-10-05 1989-02-14 Warner-Lambert Company Novel sweetener delivery systems
US4828857A (en) * 1984-10-05 1989-05-09 Warner-Lambert Company Novel sweetener delivery systems

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1617593A1 (en) * 1965-10-12 1971-04-29 Leo Pharm Prod Ltd Method of making tablets or pills

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2163648A (en) * 1984-08-03 1986-03-05 Nippon Shinyaku Co Ltd Slow release preparations
GB2163648B (en) * 1984-08-03 1989-06-01 Nippon Shinyaku Co Ltd Pharmaceutical preparation and a method of making the same
US5853758A (en) * 1992-01-13 1998-12-29 Pfizer Inc. Preparation of tablets of increased strength
EP1688143A2 (en) * 1992-06-29 2006-08-09 Kos Pharmaceuticals, Inc. Niacin-containing substained-release tablets and kits
EP1688143A3 (en) * 1992-06-29 2009-11-11 Kos Life Sciences, Inc. Niacin-containing substained-release tablets and kits
WO2014179845A1 (en) * 2013-05-09 2014-11-13 Zeenar Enterprises Pty Ltd Niacin formulation
US20160081996A1 (en) * 2013-05-09 2016-03-24 Zeenar Enterprises Pty Ltd Niacin Formulation
EP3016655A4 (en) * 2013-05-09 2017-04-12 Zeenar Enterprises Pty Ltd Niacin formulation
US10105358B2 (en) 2013-05-09 2018-10-23 Zeenar Enterprises Pty Ltd Niacin formulation
US10335403B2 (en) 2013-05-09 2019-07-02 Zeenar Enterprise Pty Ltd Niacin formulation

Also Published As

Publication number Publication date
FR2231365A1 (en) 1974-12-27
JPS5031022A (en) 1975-03-27
FR2231365B1 (en) 1977-11-04
DE2425764A1 (en) 1975-01-02

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee