GB1420449A - Production of iron salts or complexes of polymers containing carboxyl groups - Google Patents
Production of iron salts or complexes of polymers containing carboxyl groupsInfo
- Publication number
- GB1420449A GB1420449A GB3646073A GB3646073A GB1420449A GB 1420449 A GB1420449 A GB 1420449A GB 3646073 A GB3646073 A GB 3646073A GB 3646073 A GB3646073 A GB 3646073A GB 1420449 A GB1420449 A GB 1420449A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carboxyl groups
- units
- polymers
- groups
- complexes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229920000642 polymer Polymers 0.000 title abstract 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 title abstract 4
- 159000000014 iron salts Chemical class 0.000 title abstract 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 abstract 3
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 abstract 2
- 125000003172 aldehyde group Chemical group 0.000 abstract 2
- 208000007502 anemia Diseases 0.000 abstract 2
- 229920001577 copolymer Polymers 0.000 abstract 2
- 238000011282 treatment Methods 0.000 abstract 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 abstract 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 abstract 1
- 238000005705 Cannizzaro reaction Methods 0.000 abstract 1
- 239000013543 active substance Substances 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001991 dicarboxylic acids Chemical class 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052742 iron Inorganic materials 0.000 abstract 1
- 229940082629 iron antianemic preparations Drugs 0.000 abstract 1
- -1 iron salt Chemical class 0.000 abstract 1
- 235000020912 omnivore Nutrition 0.000 abstract 1
- 244000054334 omnivore Species 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000007151 ring opening polymerisation reaction Methods 0.000 abstract 1
- 239000011782 vitamin Substances 0.000 abstract 1
- 229940088594 vitamin Drugs 0.000 abstract 1
- 229930003231 vitamin Natural products 0.000 abstract 1
- 235000013343 vitamin Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F8/00—Chemical modification by after-treatment
- C08F8/44—Preparation of metal salts or ammonium salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/295—Iron group metal compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Abstract
1420449 Medicinal iron preparations DEUTSCHE GOLD-UND SILBER-SCHEIDEANSTALT 31 July 1973 [31 July 1972] 36460/73 Heading ASB [Also in Division C3] Agents for the peroral treatment of acute anaemia and/or for the prophylactic treatment of anaemia in warm-blooded omnivores, e.g. piglets, comprise iron salts or complexes of polymers having an average degree of polymerisation of 3-600 and defined in terms of the molar percentages of 5 different types of unit, including essentially units containing carboxyl groups together with units containing aldehyde groups and/or units containing hydroxy groups. Units derived from dicarboxylic acids and units obtained by ring- opening polymerisation of aldehydes are optional. Suitable polymers are (a) a copolymer containing aldehyde groups and carboxyl groups and prepared by oxidising copolymerisation of acrylic acid and acrolein, and (b) a copolymer containing hydroxy and carboxyl groups prepared by subjecting polymer (a) to a Cannizzaro reaction with NaOH. In Example 1, an iron salt/complex of a (b)-type polymer is used per se in the treatment of piglets. The polymers may be used in admixture with other pharmaceutically active substances e.g. vitamins and antibiotics, excipients or other additives, e.g. antioxidants.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2237586A DE2237586C3 (en) | 1972-07-31 | 1972-07-31 | Process for the preparation of iron salts or iron complexes containing polymers containing carboxyl groups and agents containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1420449A true GB1420449A (en) | 1976-01-07 |
Family
ID=5852216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3646073A Expired GB1420449A (en) | 1972-07-31 | 1973-07-31 | Production of iron salts or complexes of polymers containing carboxyl groups |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS5223379B2 (en) |
| BE (1) | BE803014A (en) |
| DE (1) | DE2237586C3 (en) |
| DK (1) | DK141251C (en) |
| FR (1) | FR2194423B1 (en) |
| GB (1) | GB1420449A (en) |
| HU (1) | HU165902B (en) |
| IT (1) | IT990056B (en) |
| NL (1) | NL7310573A (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102007054794A1 (en) * | 2007-11-13 | 2009-05-14 | Agilan Gmbh | Aqueous iron-dextran preparation with one or more compounds of the para-hydroxybenzoic acid esters and / or their salts |
| BR112019008785A2 (en) * | 2016-12-15 | 2019-07-16 | Nestec Sa | powdered composition comprising ferro-casein complexes and oxidation sensitive compounds |
| CN114956282B (en) * | 2022-05-09 | 2023-09-26 | 同济大学 | Composite coagulation-flocculant and preparation method and application thereof |
-
1972
- 1972-07-31 DE DE2237586A patent/DE2237586C3/en not_active Expired
-
1973
- 1973-06-06 FR FR7320563A patent/FR2194423B1/fr not_active Expired
- 1973-07-24 DK DK408973A patent/DK141251C/en active
- 1973-07-30 BE BE6044265A patent/BE803014A/en unknown
- 1973-07-30 IT IT51711/73A patent/IT990056B/en active
- 1973-07-30 HU HUDE829A patent/HU165902B/hu unknown
- 1973-07-31 JP JP48086261A patent/JPS5223379B2/ja not_active Expired
- 1973-07-31 NL NL7310573A patent/NL7310573A/xx unknown
- 1973-07-31 GB GB3646073A patent/GB1420449A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7310573A (en) | 1974-02-04 |
| DK141251B (en) | 1980-02-11 |
| HU165902B (en) | 1974-12-28 |
| JPS4953683A (en) | 1974-05-24 |
| IT990056B (en) | 1975-06-20 |
| JPS5223379B2 (en) | 1977-06-23 |
| DK141251C (en) | 1980-08-04 |
| FR2194423A1 (en) | 1974-03-01 |
| DE2237586A1 (en) | 1974-02-21 |
| FR2194423B1 (en) | 1976-07-02 |
| DE2237586C3 (en) | 1974-12-19 |
| DE2237586B1 (en) | 1974-05-09 |
| BE803014A (en) | 1974-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |