GB1415333A - Insulin derivatives - Google Patents
Insulin derivativesInfo
- Publication number
- GB1415333A GB1415333A GB5466372A GB5466372A GB1415333A GB 1415333 A GB1415333 A GB 1415333A GB 5466372 A GB5466372 A GB 5466372A GB 5466372 A GB5466372 A GB 5466372A GB 1415333 A GB1415333 A GB 1415333A
- Authority
- GB
- United Kingdom
- Prior art keywords
- insulin
- carbamoyl
- phe
- gly
- nov
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 10
- 102000004877 Insulin Human genes 0.000 abstract 5
- 108090001061 Insulin Proteins 0.000 abstract 5
- 229940125396 insulin Drugs 0.000 abstract 5
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- QYTOONVFPBUIJG-UHFFFAOYSA-N azane;cyanic acid Chemical compound [NH4+].[O-]C#N QYTOONVFPBUIJG-UHFFFAOYSA-N 0.000 abstract 1
- 230000021235 carbamoylation Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712159579 DE2159579A1 (de) | 1971-11-27 | 1971-11-27 | Insulinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1415333A true GB1415333A (en) | 1975-11-26 |
Family
ID=5826712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5466372A Expired GB1415333A (en) | 1971-11-27 | 1972-11-27 | Insulin derivatives |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS4857990A (enExample) |
| BE (1) | BE791949A (enExample) |
| DE (1) | DE2159579A1 (enExample) |
| FR (1) | FR2161063B1 (enExample) |
| GB (1) | GB1415333A (enExample) |
| NL (1) | NL7216078A (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5631347A (en) * | 1995-06-07 | 1997-05-20 | Eli Lilly And Company | Reducing gelation of a fatty acid-acylated protein |
| US5646242A (en) * | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
| US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| US5700904A (en) * | 1995-06-07 | 1997-12-23 | Eli Lilly And Company | Preparation of an acylated protein powder |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE36225B1 (en) * | 1971-01-28 | 1976-09-15 | Nat Res Dev | Improvements relating to insulin derivatives |
-
0
- BE BE791949D patent/BE791949A/xx unknown
-
1971
- 1971-11-27 DE DE19712159579 patent/DE2159579A1/de active Pending
-
1972
- 1972-11-24 FR FR7241860A patent/FR2161063B1/fr not_active Expired
- 1972-11-27 JP JP11882372A patent/JPS4857990A/ja active Pending
- 1972-11-27 GB GB5466372A patent/GB1415333A/en not_active Expired
- 1972-11-27 NL NL7216078A patent/NL7216078A/xx unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5646242A (en) * | 1994-11-17 | 1997-07-08 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
| US5693609A (en) * | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| US5922675A (en) * | 1994-11-17 | 1999-07-13 | Eli Lilly And Company | Acylated Insulin Analogs |
| USRE37971E1 (en) | 1994-11-17 | 2003-01-28 | Eli Lilly And Company | Selective acylation of epsilon-amino groups |
| US5631347A (en) * | 1995-06-07 | 1997-05-20 | Eli Lilly And Company | Reducing gelation of a fatty acid-acylated protein |
| US5700904A (en) * | 1995-06-07 | 1997-12-23 | Eli Lilly And Company | Preparation of an acylated protein powder |
Also Published As
| Publication number | Publication date |
|---|---|
| BE791949A (fr) | 1973-05-28 |
| FR2161063A1 (enExample) | 1973-07-06 |
| DE2159579A1 (de) | 1973-06-07 |
| NL7216078A (enExample) | 1973-05-29 |
| JPS4857990A (enExample) | 1973-08-14 |
| FR2161063B1 (enExample) | 1975-06-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 48R | Reference inserted (sect. 8/1949) | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |