GB1415333A - Insulin derivatives - Google Patents

Insulin derivatives

Info

Publication number
GB1415333A
GB1415333A GB5466372A GB5466372A GB1415333A GB 1415333 A GB1415333 A GB 1415333A GB 5466372 A GB5466372 A GB 5466372A GB 5466372 A GB5466372 A GB 5466372A GB 1415333 A GB1415333 A GB 1415333A
Authority
GB
United Kingdom
Prior art keywords
insulin
carbamoyl
phe
gly
nov
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5466372A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of GB1415333A publication Critical patent/GB1415333A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

1415333 Insulin derivatives SCHERING AG 27 Nov 1972 [27 Nov 1971] 54663/72 Heading C3H Novel (N<SP>α</SP> - carbamoyl - phe)B 1 - insulin, (N<SP>α</SP> - carbamoyl - gly)A 1 - (N<SP>α</SP> - carbamoylphe)B 1 - insulin and (N<SP>α</SP> - carbamoyl - gly)A 1 - (N<SP>α</SP> - carbamoyl - phe)B 1 - (N<SP>#</SP> - carbamoyllys)B 29 - insulin are prepared by carbamoylation of insulin at a controlled pH value, using, e.g. an alkali metal or ammonium cyanate. Pharmaceutical compositions for use in treating diabetes in insulin-resistant patients comprise one of the above novel insulin derivatives together with a suitable diluent or carrier and are preferably administered parenterally.
GB5466372A 1971-11-27 1972-11-27 Insulin derivatives Expired GB1415333A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19712159579 DE2159579A1 (en) 1971-11-27 1971-11-27 INSULINE DERIVATIVES

Publications (1)

Publication Number Publication Date
GB1415333A true GB1415333A (en) 1975-11-26

Family

ID=5826712

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5466372A Expired GB1415333A (en) 1971-11-27 1972-11-27 Insulin derivatives

Country Status (6)

Country Link
JP (1) JPS4857990A (en)
BE (1) BE791949A (en)
DE (1) DE2159579A1 (en)
FR (1) FR2161063B1 (en)
GB (1) GB1415333A (en)
NL (1) NL7216078A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
US5646242A (en) * 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
US5693609A (en) * 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US5700904A (en) * 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE36225B1 (en) * 1971-01-28 1976-09-15 Nat Res Dev Improvements relating to insulin derivatives

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5646242A (en) * 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
US5693609A (en) * 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US5922675A (en) * 1994-11-17 1999-07-13 Eli Lilly And Company Acylated Insulin Analogs
USRE37971E1 (en) 1994-11-17 2003-01-28 Eli Lilly And Company Selective acylation of epsilon-amino groups
US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
US5700904A (en) * 1995-06-07 1997-12-23 Eli Lilly And Company Preparation of an acylated protein powder

Also Published As

Publication number Publication date
BE791949A (en) 1973-05-28
DE2159579A1 (en) 1973-06-07
NL7216078A (en) 1973-05-29
FR2161063B1 (en) 1975-06-20
FR2161063A1 (en) 1973-07-06
JPS4857990A (en) 1973-08-14

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Legal Events

Date Code Title Description
PS Patent sealed
48R Reference inserted (sect. 8/1949)
PLNP Patent lapsed through nonpayment of renewal fees